[PDF] Top 20 Presepsin as a diagnostic marker for sepsis: evidence from a bivariate meta-analysis

... retrieved from the articles included first author, publication year, the country of origin, samples, presepsin assay methods, cutoff value, and true positive, false positive, true negative, and false ... See full document

... in sepsis [3], develop- ing diagnostic strategies for infection is still required for accurate bedside diagnosis of ...of sepsis [38, 39], more recent studies have produced conflicting results ... See full document

... CD14 from the cell membrane and releasing into circulation during infection status, the LPS–LPB– CD14 complex yields soluble ...or presepsin. Presepsin increases signifi- cantly in the blood of ... See full document

... CD14 from the cell membrane, yielding sol- uble CD14 (sCD14), which is also directly secreted by he- patocytes [8, ...renamed presepsin [10]. Presepsin has recently been reported to increase in ... See full document

... detect sepsis reported such as procalcitonin (PCT), C-reactive protein (CRP), lipopolysaccharide-binding protein (LBP), interleukins, provasopressin, and myeloid cells expressing triggering receptor-1 (TREM-1) ... See full document

... using Meta-DiSc (version ...a bivariate boxplot were used to measure the heterogen- eity caused by non-threshold ...the bivariate boxplot, indicating that the hetero- geneity was significant due to ... See full document

... The output of the QUADAS-2 tool is summarized in Fig. 2. Two studies evaluated the optimal cutoff value to calculate sensitivity and specificity instead of using the predefined value scored ‘high risk’ in the index test ... See full document

... diagnosing sepsis. We used a bivariate random-effects model, and the pooled sensitivity and specificity were ...pooled analysis showed that nCD64 seemed to have high degree of diagnostic ... See full document

... This was a single-center, prospective clinical study carried out in Hebei General Hospital, China. A total of 44 patients with suspected lung cancer were recruited between January 2018 and June 2018. All patients ... See full document

... distinguished from total cfDNA using somatic mutations analysis, the very low presence of ctDNA (often only ...qualitative analysis and specific optimization procedure for each ... See full document

... the diagnostic test measures ...7–9], bivariate copula distributions [10–12], bivariate mixture models [13, 14], nonparametric solutions ...the bivariate random-effects model [7, 8], as it is ... See full document

... or diagnostic observations only, intervention not indicated; Grade 2 means moderate, minimal, local or noninvasive intervention indicated, limiting age-appropriate instrumental activities of daily living ... See full document

... statistically significant and a random effects model was used for pooling the data; otherwise, a fixed ef- fect model was utilized. The summary receiver oper- ating characteristic (SROC) curve was also conducted based on ... See full document

... severe sepsis or septic shock) was made according to the criteria of the International Guidelines for Manage- ment of Severe Sepsis and Septic Shock [4,16] and after- wards obtained by clinicians by ... See full document

... of sepsis for saving lives. Sepsis is a systemic inflammatory response syndrome (SIRS) that affect all ...of sepsis development that helps in identifying relevant biomarkers to diagnose sepsis ... See full document

... We selected publications in a strict manner, but potential heterogeneity was still present in our study. We found that miRNA profiling and specimen type may have partially contrib- uted to such heterogeneity. Therefore, ... See full document

... To reveal the relationship between DEmiRNAs and prog- nosis, we performed Kaplan–Meier analysis. Our results revealed that miR126 (P = 0.007) and miR424 (P = 0.017) were significantly associated with PAAD ... See full document

... natal sepsis episodes and was the most-diagnostic mea- sure of confirmed sepsis; in conjunction with the ANC, the CD64 index showed promise for replacing the sub- jectively measured band count and ... See full document

... a diagnostic cutoff set at ≥466.5 pg/mL, we observed that Presepsin had a higher sensitivity (91 vs 80 %) and a lower specificity (55 vs 59 %) than ...Its diagnostic accuracy significantly improved ... See full document

... However, the mechanisms of a postnatal in- crease in AFP remain unexplained, but possibilities include an increased rate of synthesis in the liver, or prolonged half-life due to altered clearance of blood. During the ... See full document