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Prevalence of factor VIII inhibitors in haemophilia a patients who received factor VIII therapy

Prevalence of factor VIII inhibitors in haemophilia a patients who received factor VIII therapy

... of Factor VIII is the central feature of ...3 Haemophilia A is the inherited deficiency of blood coagulation factor leads to lifelong bleeding disorder ,the factors most commonly found ... See full document

120

Treatment of Haemophilia A by Replacement Therapy using  Factor VIII Inhibitors

Treatment of Haemophilia A by Replacement Therapy using Factor VIII Inhibitors

... of factor VIII gene is spotted by the presence on the end of the lengthy arm of chromosomes ...the factor VIII is a polypeptide containing 2332 amino acids (inactivated flowing master ... See full document

7

Prevalence of Inhibitors to Factor VIII after 25 Exposures to Factor VIII Concentrates and/or Blood Products in Persons with Hemophilia A

Prevalence of Inhibitors to Factor VIII after 25 Exposures to Factor VIII Concentrates and/or Blood Products in Persons with Hemophilia A

... of factor VIII antibodies in patients with hemophilia A depend in part upon the severity of the ...However, patients with inhibitors have more difficulty in achieving hemostasis and ... See full document

17

Screening and quantitative estimation of factor VIII inhibitors by Nijmegen-Bethesda assay in hemophilia a patient of Southern Odisha, India

Screening and quantitative estimation of factor VIII inhibitors by Nijmegen-Bethesda assay in hemophilia a patient of Southern Odisha, India

... criteria- Haemophilia-A patients attending department of pathology ...of Haemophilia A under Haemophilia society of Berhampur and patients who were diagnosed with hemophilia-A in ... See full document

6

Factor VIII bypassing activity of bovine tissue factor using the canine hemophilic model

Factor VIII bypassing activity of bovine tissue factor using the canine hemophilic model

... replacement therapy of the missing coagulation factor, factor VIII, is frequently complicated by the development of neutralizing ...tissue factor, a known initiator of coagulation, was ... See full document

7

Factor VIII/von Willebrand factor protein  Galactose a cryptic determinant of von Willebrand factor activity

Factor VIII/von Willebrand factor protein Galactose a cryptic determinant of von Willebrand factor activity

... normal Factor VIII/von Willebrand factor protein has the ability to agglutinate or aggregate normal platelets in the presence of ristocetin (von Willebrand factor ...Willebrand factor ... See full document

5

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII

... hemophilic patients, 2 limitations should be considered when appraising the results of this ...ing patients with chronic and acute infectious or inflammatory dis- eases or on immunoactive ...only ... See full document

17

Detection of carriers of classic hemophilia using an immunologic assay for antihemophilic factor (factor VIII)

Detection of carriers of classic hemophilia using an immunologic assay for antihemophilic factor (factor VIII)

... The relation between functional antihemophilic factor (AHF) activity and AHF-like antigen was studied in the plasma of 25 known carriers of hemophilia. In 23 cases, this relationship was significantly different ... See full document

5

High factor VIII levels contribute to the thrombotic risk in families with factor V Leiden

High factor VIII levels contribute to the thrombotic risk in families with factor V Leiden

... In order to explam the different venous thrombotic nsks in first-degree relatives of probands of selected thrombophilic families and first-degree relatives of unselected patients with th[r] ... See full document

7

Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A

Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A

... Willebrand factor (VWF) and factor VIII (FVIII) are currently ...replacement therapy in patients with severe or intermediate forms of von Willebrand disease, in whom other treat- ments ... See full document

9

Studies on the purification of antihemophilic factor (factor VIII): I  Precipitation Of Antihemophilic Factor By Concanavalin A

Studies on the purification of antihemophilic factor (factor VIII): I Precipitation Of Antihemophilic Factor By Concanavalin A

... Concanavalin A precipitates antihemophilic factor from normal plasma. Combining this precipitation with other techniques, we were able to separate fractions rich in antihemophilic activity from human plasma with ... See full document

9

Acquired Factor VIII Inhibitor in Juvenile Rheumatoid Arthritis

Acquired Factor VIII Inhibitor in Juvenile Rheumatoid Arthritis

... Acquired circulating inhibitor to factor VIII (FVIII) has been reported in both hemophiliacs and nonhe- mophiliac&.. FVIII inhibitor occurs in 10% to 20% of patients with severe, cla[r] ... See full document

6

Hemophilia A gene therapy via intraosseous delivery of factor VIII-lentiviral vectors

Hemophilia A gene therapy via intraosseous delivery of factor VIII-lentiviral vectors

... Although ex vivo HSC transduction/transplantation protocols can successfully deliver FVIII into HemA mice [6, 31], the procedure requires pre-conditioning using potentially toxic, myelosuppressive agents. On the ... See full document

7

Effects of triiodothyronine induced hypermetabolism on factor VIII and fibrinogen in man

Effects of triiodothyronine induced hypermetabolism on factor VIII and fibrinogen in man

... subjects. Factor VIII (antihemophilic globulin) activity increased from 109 to 167% (P < ...in factor VIII activity and fibrinogen were mediated by beta adrenergic receptors, propranolol ... See full document

8

Treatment of bleeding episodes in haemophilia A complicated by a factor VIII inhibitor in patients receiving Emicizumab. Interim guidance from UKHCDO Inhibitor Working Party and Executive Committee

Treatment of bleeding episodes in haemophilia A complicated by a factor VIII inhibitor in patients receiving Emicizumab. Interim guidance from UKHCDO Inhibitor Working Party and Executive Committee

... and patients/parents should agree the exact dose and frequency of rFVIIa that can be used at home and when advice should be sought from the CCC if the bleed does not ... See full document

6

THE SURVIVAL OF FACTOR VIII (ANTIHEMOPHILIC GLOBULIN) AND FACTOR IX (PLASMA THROMBOPLASTIN COMPONENT) IN NORMAL HUMANS

THE SURVIVAL OF FACTOR VIII (ANTIHEMOPHILIC GLOBULIN) AND FACTOR IX (PLASMA THROMBOPLASTIN COMPONENT) IN NORMAL HUMANS

... Half-lives and standard errors of estimate of the second components of the Factor VIII survival curves in five Figure 2 shows the survival curve for Factor normal human recipients VIII i[r] ... See full document

9

Some Effects of Calcium on the Activation of Human Factor VIII/Von Willebrand Factor Protein by Thrombin

Some Effects of Calcium on the Activation of Human Factor VIII/Von Willebrand Factor Protein by Thrombin

... When Factor VIII/von Willebrand factor (FVIII/vWF) protein is rechromatographed on 4% agarose in 0.25 M CaCl 2 , the protein and vWF activity appear in the void volume, but most of the FVIII ... See full document

11

Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets

Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets

... The presence of specific Factor VIII/von Willebrand factor FVIII/vWF binding sites on human platelets has been demonstrated by using 125I-FVIII/vWF and washed human platelets.. Binding i[r] ... See full document

10

The Properties of Immune Complexes Formed by Human Antibodies to Factor VIII

The Properties of Immune Complexes Formed by Human Antibodies to Factor VIII

... to Factor VIII inactivate its procoagulant activity, they do not form immunoprecipitates when tested with this ...human Factor VIII with four high-titer human anti- Factor VIII, ... See full document

11

Potential role of a new PEGylated recombinant factor VIII for hemophilia A

Potential role of a new PEGylated recombinant factor VIII for hemophilia A

... of patients’ ...pediatric patients’ learning how to self-infuse? What, if any, is the effect of the frequent and continuous exposure to PEG and the potential buildup in the tissues? So far, there is no ... See full document

8

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