[PDF] Top 20 Prevalence of HER-2/ neu receptor amplification and its effects over prognosis of the patients with breast cancer

... operated patients with biopsy proven breast carcinoma were included in this ...the patients was collected after taking informed consent from patient, spouse or ...staging, patients taking ... See full document

... and HER-2/ neu were examined with regard to their ability to predict DFS, OS and rate of recurrence, as well as ...All patients were randomly selected from one department (Frauenklinik ... See full document

... factor receptor, family of tyrosine kinases, is involved in critical signaling pathways that control cell proliferation and survival ...this receptor, due to acquired genetic defects that result in gene ... See full document

... of breast cancer management. Oestrogen and progesterone receptor examination is recommended for prediction of response to hormonal ...positive patients showed poor prognosis similar to ... See full document

... the breast can exhibit different biology has necessitated the identification of biological parame- ters that might improve risk assessment; the evaluation of HER-2/neu expression is a typical ... See full document

... factor receptor (EGFR) family. Activation of the HER2/neu gene results in synthesis of 185kD transmem- brane protein, whose intracellular domain possesses tyr- osine kinase activity and through ... See full document

... Oncogene HER-2/neu was originally discovered in che- mically induced rat neuroglioblastomas [6] and is located on chromosome 17q21 and codes for a transmembrane glycoprotein of ...factor ... See full document

... of patients with HER-2/neu negative tumors compared to those with HER-2/neu positive tumors suggests the presence of high affinity T cells in the ...in patients ... See full document

... cDNA amplification (real time PCR step): The cDNA was used in SYBR green based quantitative real time PCR for Relative Quantification (RQ) of HER-3 gene expression by SensiFASTTMSYBR Lo-ROX Kit, USA, using ... See full document

... ER-mediated breast cancer cell stimulation by suppression of oestrogen synthesis rather than by blocking the ER ...hormone receptor-positive breast cancers, have been investigated by several ... See full document

... advantages over standard ...side effects typical of conventional ...against cancer have failed to fulfill the above expectations in clinical ... See full document

... Tables 2 and ...than cancer; second, we did not use HER-2 status in the model, which was not available until 2010, so the conclusion might be ...21-gene breast recurrence score (RS) may ... See full document

... Background: Breast cancer is the leading cancer among ...of Her-2/neu in patients with invasive breast carcinoma in Morocco, and to study the association between ... See full document

... cytoplasmic receptor in unliganded ...Estrogen receptor rapidly diffuses into the cytoplasm, it migrates from cytosol to nucleus, then dimerisation of the receptor occurs and subsequently it binds ... See full document

... The simplest and most widely used method is mitotic count. In recent times, IHC for Ki 67 is being used to determine tumour proliferation. In present study, significant correlation was found between Ki-67 (index<15) ... See full document

... The forty cases of urothelial tumors received in the past 1 year were included in the study. The clinical data of the cases were recorded and Haematoxylin and Eosin (H&E) stained slides and blocks were retrieved from ... See full document

... deposits, 2 = 1-3 positive nodes and 3 = more than three positive nodes, and the values of G, 1 = well differentiated, 2 = moderately differentiated and 3 = poorly differentiated ...the patients is ... See full document

... 758 patients with early stage, node positive breast cancer with low to intermediate HER2 expression with a primary endpoint of 3 year disease free survival ...(DFS). Patients received either ... See full document

... staining, 2 denotes 1%–10% nuclei staining, 3 denotes 11%–33% nuclei stain- ing, 4 denotes 34%–66% nuclei staining, and 5 denotes 67%–100% nuclei ...staining, 2 denotes moderate staining, and 3 denotes ... See full document

... Thirty-five invasive urinary bladder carcinomas were examined in this study. Only invasive bladder tumors were included based on availability of representative paraffin embedded tumor tissue, 26 of this patients ... See full document