[PDF] Top 20 Probing the role of stearoyl CoA desaturase–1 in hepatic insulin resistance
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Probing the role of stearoyl CoA desaturase–1 in hepatic insulin resistance
... reduced hepatic steatosis, the current study shows that short-term treatment with Scd1- targeted ASO results in increased hepatic TG levels relative to both high-fat– and standard chow–fed animals treated ... See full document
5
Critical role of stearoyl CoA desaturase–1 (SCD1) in the onset of diet induced hepatic insulin resistance
... of hepatic Akt activity can per se decrease blood glucose and insulin levels, induce fatty liver, and suppress the expression of Glc-6-Pase and PEPCK within just 4 days ...of hepatic Akt, they are ... See full document
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Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet
... and insulin sensitivity in elderly men [40]. In DIO, OP rats may induce SCD-1 to protect them from excess SFA ...protective role for SCD-1 could be supported by our finding that the ... See full document
11
Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance
... between desaturase indices derived from different serum lipid fractions and adipose tissue are unclear, as well as their associations with obesity and insulin ...between desaturase indices as ... See full document
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One-night sleep deprivation induces changes in the DNA methylation and serum activity indices of stearoyl-CoA desaturase in young healthy men
... enzyme stearoyl-CoA desaturase (SCD), which is predominantly expressed in the liver, plays a central role in the desaturation of saturated fatty acids (FAs), thus having important implications ... See full document
7
Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes
... of hepatic and/or adipose stear- oyl-CoA desaturase-1 (SCD1), the rate-limiting enzyme in biosynthesis of monounsaturated fatty acids, which are preferred for triglyceride assembly ... See full document
5
Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells
... (e.g. insulin, leptin) (Mauvoisin and Mounier 2011). However, SREBP-1 transcription factor appears as the main regulator in this ...essential role in either the activation by sterol depletion or the ... See full document
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Stearoyl-CoA Desaturase-1 Is Associated with Insulin Resistance in Morbidly Obese Subjects
... and insulin resistance, or perhaps a ...of insulin re- sistance ...the insulin resistance. In the subjects with high insulin resistance, the VAT has lower levels of SCD1 ... See full document
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Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl CoA desaturase–1
... fasting insulin levels on chow diet but not on ...a role in improving insulin sensitivity in SCD1-deficient mice by potentiating the insulin-signaling cascade and glucose trans- porter 4 ... See full document
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Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in the <em>FTO </em>gene
... However, the coordinated regulation of postprandial glucose and BA metabolism in regulating lipid and glucose homeo- stasis in humans is complex and needs further investigation. The strength of the present study is the ... See full document
8
Role of receptor for advanced glycation end products (RAGE) in liver disease
... We have previously shown that AGE-RAGE interaction- mediated, NADPH oxidase-induced ROS generation stim- ulates proliferation and tube formation of ECs, the key steps of tumor angiogenesis, through VEGF expression via ... See full document
7
Study Protocol: insulin and its role in cancer
... All subjects will be recruited from out patient division of M.S. Ramaiah Memorial Hospital, Bangalore, India and Cancer Institute, Chennai, India. Patients who are below age of 50, with carcinomas of breast, GIT, liver, ... See full document
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First study of correlation between oleic acid content and SAD gene polymorphism in olive oil samples through statistical and bayesian modeling analyses
... However, up to this time the subject about the lipid- lowering properties of virgin olive oil is still under debate. Indeed, the course of action controlling this property is complex. Recently, Estruch and coworkers ... See full document
8
No Dose Response Relationship in the Effects of Commonly Consumed Sugars on Risk Factors for Diabetes across a Range of Typical Human Consumption Levels
... Recently considerable attention has been focused on consumption of fructose containing sugars including fructose itself, high fructose corn syrup (HFCS), sucrose and their possible role in promoting Type 2 ... See full document
12
Hypothalamic resistin induces hepatic insulin resistance
... the hepatic mRNA levels for the rate-limiting enzymes for gluconeogenesis, G6Pase, and phosphoenolpyruvate (PEP) carboxykinase (PEPCK) (Figure 2E) On the other hand, both icv and MBH each resistin moderately ... See full document
10
Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans
... euglycemia, insulin increased glucose disposal in nondiabetic but not diabetic subjects indicating marked extrahepatic ...contrast, insulin- induced suppression of glucose release was only minimally less (P ... See full document
9
Akt Controls Adipocyte Function And Systemic Metabolism
... in insulin suppression of lipolysis is likely in Adipo-AKT2 KO ...an insulin bolus or during hyperinsulinemic-euglycemic clamp (Koren et ...of insulin-mediated suppression of circulating FFAs is ... See full document
181
Role of resistin in diet induced hepatic insulin resistance
... of insulin resistance? To address this question, we sought to reverse the diet-induced increase in circulating resistin levels to assess its impact on insulin action and glucose ...improved ... See full document
9
Stearoyl Coenzyme A Desaturase 1 Is Associated with Hepatitis C Virus Replication Complex and Regulates Viral Replication
... acid desaturase, which produces oleic and palmitoleic acids in the yeast Saccharo- myces cerevisiae, inhibited brome mosaic virus (BMV) RNA rep- lication by more than 95% ...intracellular desaturase index, ... See full document
15
Hypertension, hypertriglyceridemia, and impaired endothelium dependent vascular relaxation in mice lacking insulin receptor substrate 1
... consequently increasing production of triglycerides, but also reduces LPL activity. LPL is an enzyme located on the endo- thelial surface of adipose tissue and skeletal and heart muscle which hydrolyzes triglycerides in ... See full document
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