[PDF] Top 20 Protection against lead-induced hepatic lesions in Swiss albino mice by ascorbic acid

... of hepatic toxicity; vitamin C helps in restoring glutathione level, thus offering a good protection against lead generated ...toxicity. Lead binds with the thiol groups (-SH) of the ... See full document

... mutagenicity induced by metals such as cadmium 19 ...(ascorbic acid). Ascorbic acid shows anti-oxidant, anti-inflammatory and anti-mutagenic properties 24 ...to ascorbic ... See full document

... Reduced protein content was observed in Cd-treated group. Some authors also reported similar trend in their research findings [37,38,43,46-49]. It was suggested that decline in protein content may be due to reduced level ... See full document

... electro-shock induced convulsions and pentylenetetrazol-induced clonic convulsions methods were used for the evaluation of anticonvulsant activity in swiss albino ... See full document

... In-vivo study of effect of lead on pro-inflammatory TNF-α cytokine release in testicular macrophages isolated from lead intoxicated adult male Swiss albino mice.. DISCUSSION Lead is a he[r] ... See full document

... C against lead toxicity animals were divided into three groups of six rats ...given lead acetate at a dose level of ...with lead acetate and result were analyzed for hematological parameter ... See full document

... female mice were transferred in the evening to the cages containing male mice in the ratio of ...1 mice termed as control received distilled water. Group 2 mice received desvenlafaxine (IPCA, ... See full document

... 3’-di-0-methylellagic acid and quercetol (methyllic ester)and pharmacological activities reported that the plant material(s) may be used as anti-malarial, laxative, expectorant, antidiarrheal, anthelmintic, ... See full document

... folic acid, thiamine and niacin, it also contains minerals such as Ca, Mg, Co, Al, Na, Cl, Fe, K, and S) (Shelton, ...effect against hepatotoxicity produced by ... See full document

... male Swiss albino mice (6-8 weeks old) were procured from Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar ...standard mice pellet diet (Hindusthan Liver Limited, India) and ... See full document

... was assessed by counting number of wriths (constriction of abdomen, turning of trunk and extension of hind legs) in mice. Number of wriths per animal was counted during a 10 min series beginning 5 min after the ... See full document

... Genistein a tyrosine kinase inhibitor, compete with the ATP binding site of the catalytic domain of several oncogenic tyrosine kinases. This is possible because of structural similarities between ATP and the TKIs. ... See full document

... Control group received 1% Tween-80 in distilled water at the dose of 10 mL/kg body weight, and positive control group received diclofenac sodium at the dose of 25 mg/kg body weight. Test group I and II were treated with ... See full document

... analgesics. But this test is largely insensitive to non-steroidal anti-inflammatory agents. The % increase in the latency of the licking response in mice in the hot plate method for the standard drug pentazocine ... See full document

... (2-nitrobenzoic acid) (Ellman’s reagent) to yield a yellow chromophore which was measured ...trichloroacetic acid (TCA) and centrifuged (Remi cold centrifuge) at 2000×g for 10min at ... See full document

... Vitamin C or Ascorbic acid is a water soluble organic anti oxidant property. It is white crystalline in appearance and stable in dry form. Vitamin C has many functions it can function as a coenzyme or as a ... See full document

... The plant extract of Acrostichum aureum Linn (Family- Pteridaceae), was themed to phytochemical and pharmacological exploration to determine antioxidant, and analgesic activity to afford an appropriate guide, that may be ... See full document

... The analgesic activity of the sample was studied using acetic acid induced writhing test in mice (8,9). Experimental animals were randomly selected, and divided into four groups denoted as control, ... See full document

... To demonstrate the synthetic utility of 2, in the synthesis of various bridgehead six membered heterocycles, the compound 2 was refluxed with chloroacetic acid and fused sodium acetate in ethanol. This reaction ... See full document

... activity against HepG2, MCF-7, and HeLa cell lines ...cells, induced S and G2/M phase arrests of the cell cycle, and stimulated apoptosis of HepG2 cells, and induced activation of caspase-3, -8, and ... See full document