[PDF] Top 20 QSAR Analysis on β-carboline as Antitumor Agent
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QSAR Analysis on β-carboline as Antitumor Agent
... The thermodynamic, spatial, electronic, and topological parameters shown in Table 2 were calculated for QSAR analysis. Thermodynamic parameters describe free energy change during drug receptor complex ... See full document
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Therapeutic journey of synthetic betacarboline derivatives: A short review
... on β- carboline derivatives to explore the structural necessities for antitumor ...3D QSAR studies were done using V-Life Sciences MDS ...3D- QSAR was performed using the Step Wise K ... See full document
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QSAR IN SILICO METHOD ANALYSIS OF ANTITUMORAL ACRIDONES AS A ANTICANCEROUS AGENT AND DIPIPERIDINES AS CCR2 ANTAGONISTS
... as antitumor acridones and Dipiperidines as CCR2 antagonist were ...(QSAR) analysis using combination of various descriptors such as steric, electronic and ...significant QSAR equation for ... See full document
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In-Silico Qsar Analysis Of Substituted Dipiperidines As Ccr2 Antagonists And Antitumoral Acridones As A Anticancerous Agent
... as antitumor acridones and Dipiperidines as CCR2 antagonist were selected, having the cytotoxic activity against both HL-60 and P388 ...(QSAR) analysis using combination of various descriptors such ... See full document
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Some substrates of P glycoprotein targeting β amyloid clearance by quantitative structure activity relationship (QSAR)/membrane interaction (MI) QSAR analysis
... single agent. As a result, these cells become resistant to the selective agent and cross-resistant to a broad spectrum of structurally and functionally dis- similar ... See full document
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Computational Chemistry Application of Physicochemical Descriptors: QSAR Study on Some β Carboline Compounds
... the QSAR study on some β-carboline compounds extracted from Harmine, in order to predict new unprepared derivatives with the best activity as a potent anticancer ...of β-carboline ... See full document
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Enhanced NK cell adoptive antitumor effects against breast cancer in vitro via blockade of the transforming growth factor-β signaling pathway
... DNT β RII compared with the TGF- β -mediated phosphorylation of Smad-2 and Smad-3 as observed using Western blotting in parental NK cells and in NK/pTAR-GET ...DNT β RII vector blocked the TGF- ... See full document
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Theoretical Investigation on the Antitumor Drug: ThioTEPA and its Interaction with S-donor Biomolecules and DNA Purine Bases
... [13-16] analysis data (Table 2) shows that the thioTEPA molecule uses low content of p orbitals for C-H bond and high content of p orbitals for C-C and C-N due to overcoming the angular pressure of aziridine ... See full document
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Volume 4 | Issue 1 - 2014
... The QSAR model has been successfully developed with a good correlative and predictive ability for predicting anti-convulsant ...This QSAR model exhibiting a high degree of accuracy was then validated by ... See full document
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QSAR analysis of N-Alkyl imidazole analogues as antibacterial agents
... 2D-QSAR analysis suggested that for all the three microbes, substitution at R 1 position very much dominates the activity as compared to the indicator variable at R 2 and R 3 position ... See full document
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Topological and Quantum chemical descriptors based Comparative Quantitative Structure Activity Relationship of benzothiazole derivatives
... Fourth QSAR model: The fourth QSAR model is obtained when multi linear regression analysis is done by taking log P as first descriptor, Shape index (Kappa alpha, order 1) as second descriptor, dipole ... See full document
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IN SILICO MOLECULAR MODELING OF SALICYL HYDRAZONE ANALOGUES AS TROPOMYOSIN KINASE (TRKA) INHIBITORS
... present analysis, quantum chemical parameters based on density functional theory, Topological discriptors were calculated at GGA-PW91 level of ...(MLR) analysis was used to select significant molecular ... See full document
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Efficacy and Mechanistic Evaluation of Tic10, A Novel Antitumor Agent
... potent antitumor effects in vivo even when given as a single dose as a monoagent, was orally active, and increased TRAIL protein and markers of TRAIL-mediated apoptosis in ... See full document
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2D QSAR Study of New 4β Anilino 4’ O demethyl 4 desoxypodophyllotoxin Derivatives as Potential Antitumor Agents
... derived QSAR model, it can be concluded that antitumor activity of 4β-anilino- 4’-O-demethyl-4- desoxypodophyllotoxin derivatives is strongly influenced by physicochemical descriptors like Quadrupole1, - ... See full document
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Quantitative structure activity relationship analysis of some 2 substituted halogenbenzimidazoles analogues using computer aided drug designing technique
... Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains the leading cause of mortality due to a bacterial pathogen. WHO estimated that there were 8.8 million new cases of tuberculosis in 2020. No new drug ... See full document
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Improved PCR-RFLP Method For Her-2 Ile655val Breast Cancer Patients Detection
... As an antitumor agent, treatment with trastuzumab mechanism is not fully understood. Tratsuzumab been reported to induce antibody dependent cellular toxicity (ADCC), inhibits the cleavage domain of ... See full document
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<p>Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67</p>
... Controlled release and targeted nano-drug delivery sys- tems have attracted extensive attention in the fi eld of drug delivery. 24–26 Among novel delivery systems, polymeric micelles have been developed as ideal carriers ... See full document
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Qsar modeling studies on 2,4-thiazolidinediones as potential α-glucosidase inhibitors
... MLR analysis was carried out using software Molegro Data Modeler v ...2. QSAR models were generated using MLR based on manual selection method and were correlated to biological ... See full document
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Complex of C60 Fullerene with Doxorubicin as a Promising Agent in Antitumor Therapy
... The tumors were surgically removed, and cell lysates were prepared by EDTA extraction. After removal of unlysed cell remnants and nuclei by centrifugation in the Eppendorf micro-centrifuge (5 min, 10,000 rpm, 10,200×g); ... See full document
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In vitro evaluation of β carboline alkaloids as potential anti Toxoplasma agents
... To analyze the effect of harmane, norharmane and har- mine alkaloids on the ability of T. gondii to infect host cells, 2.5×10 6 extracellular tachyzoites (almost all com- prising a G1 arrested form of the parasite) were ... See full document
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