[PDF] Top 20 Quantitative structure retention relationships for rapid method development in hydrophilic interaction liquid chromatography of pharmaceutical compounds

... in pharmaceutical analysis can be found in a recently published review ...are hydrophilic phases with silanol groups and siloxane bridges, which can display hydrogen donor and acceptor ...less ... See full document

... reversed-phase liquid chromatography [RPLC], hydrophilic interaction liquid chromatography [HILIC], or ion chromatography [IC]), stationary phase, and the broad mobile ... See full document

... the retention times for the target ...of compounds for QSRR calculations, including the ratio of retention factor (k- ratio), the Tanimoto similarity (TS), the log D and log P similarity, plus a ... See full document

... The liquid chromatography coupled with tandem mass spectrometer (LC‑MS/MS) system consists of a Finnigan surveyor autosampler, surveyor LC pump plus solvent delivery system and a column oven (Thermo ... See full document

... found to be linear in the range of 80-240 mcg/ml with correlation coefficient of 0.9999. Linear regression least square fit data obtained from the measurements are given in table I. The respective linear regression ... See full document

... Two mechanistic proposals were introduced in order to explain the antioxidant preventive action of phenolic compounds (ArOH): (i) H-atom transfer (reaction 4, Figure 2) and (ii) electron transfer (reaction 5, ... See full document

... their pharmaceutical formulation. In this work a simple, rapid, accurate and sensitive analytical methods have been developed and ...This method is a direct spectro chromate graphic analytical ... See full document

... chromatographic retention (log k) values to fathead minnows were available [12] were ...studied compounds and their experimental log k values for training and test sets are shown in Table 1 and Table ... See full document

... RP-HPLC method for the estimation of Nevirapine using simple mobile phase with low buffer concentration compared to the proposed ...The method gives the short analysis time (< 5 min). The method ... See full document

... Reactive distillation is a combination of separation and reaction in a single process. Commercial reactive distillation processes for the manufacture of methyl t-butyl ether (MTBE) and methyl acetate were suc- cessfully ... See full document

... Otherwise specified, all chemical and reagents were supplied by Sigma-Aldrich (Poole Dorset, UK) with the highest purity available. All solutions were prepared with high-performance liquid chromatography ... See full document

... of Pharmaceutical Analysis 75 JKKMMRF College of Pharmacy closely related to the analyte to confirm that a positive response is not ...in chromatography should be investigated at an appropriate ... See full document

... It was previously reported predicted that photolysis of methylcobalamin was initiated by a ligand to ligand charge transfer (LLCT) excited state, which included elevation of an electron of the cobalt-carbon adhesion to a ... See full document

... analytical method for routine analysis is ...chromatographic method remains as a better choice to meet the ...common method of choice and thus, its properties restrict the use of common RP-HPLC ... See full document

... first method describes the development of reverse phase HPLC method for Prasugrel hydrochloride in the presence of impurities and degradation products generated from the forced degradation ...HPLC ... See full document

... more rapid than the chromatographic mass transfer processes ...many chromatography columns are not stable to the high pH values required to increase the rate of ...using liquid chromatography ... See full document

... “Method Development and Validation of Sumatriptan in Bulk and Pharmaceutical Dosage Forms By UV Spectrophotometric Method”, International Journal of Pharmaceutical & Biological ... See full document

... reliable, rapid and sensitive isocratic reverse phase high‑performance liquid chromatography method has been developed and validated for assay of ketorolac tromethamine in tablets and ... See full document

... should be carried out on a drug product to establish its inherent stability characteristics, leading to identification of degradation products and hence supporting the suitability of the proposed analytical procedures. ... See full document

... The effect of wide range of excipients and other additives usually present in the formulation of Amlodipine Besylate and Hydrochlorothiazide in the determinations under optimum conditions was investigated. The ... See full document