[PDF] Top 20 A 12-Week, Randomized, Controlled Trial with a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome with Constipation
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A 12-Week, Randomized, Controlled Trial with a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome with Constipation
... models, linaclotide treat- ment accelerated gastrointestinal transit and reduced visceral nociception ( 14 ); in human phase 2 clinical studies, it accele- rated colonic transit ( 15 ) and improved abdominal pain ... See full document
12
Linaclotide: evidence for its potential use in irritable bowel syndrome and chronic constipation
... The efficacy of linaclotide in patients with chronic con- stipation was initially evaluated in a randomized, double- blind, placebo-controlled pilot ...chronic constipation were ... See full document
9
Efficacy and indication optimization of Chinese medicine (Tiao Chang Ke Min granules) for diarrhea predominant irritable bowel syndrome: study protocol for a randomized controlled trial
... parallel-group, randomized, double-blind, placebo-controlled trial embedded with outcome predictive ...be randomized into either a TCKM granule group or a placebo ...is 4 weeks and the ... See full document
9
Tegaserod in the treatment of irritable bowel syndrome (IBS) with constipation as the prime symptom
... Abstract: Irritable bowel syndrome with constipation (IBS-C) as the predominant bowel symptom is a prevalent disorder, characterized by recurring abdominal pain/discomfort, bloating, ... See full document
12
Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, Fingolimod will change therapeutic paradigm approach
... significant efficacy throughout many trials, but they produce different side-effect profiles in ...superior efficacy compared with placebo and interferon β-1a in Phase III studies and has been approved in ... See full document
12
The Performance Benefits of Training with a Sauna Suit: A Randomized, Controlled Trial
... both hot (52 sec) and temperate conditions (38 sec) were significantly faster (p < 0.05) in the sauna suit treatment group after 2wks of training. Relative to the control group, sweat rate and thermoregulation ... See full document
11
Do COX 2 inhibitors provide additional pain relief and anti inflammatory effects in patients with rheumatoid arthritis who are on biological disease modifying anti rheumatic drugs and/or corticosteroids? Post hoc analyses from a randomized clinical trial with etoricoxib
... for efficacy analyses was all ran- domized patients who received ≥1 dose of study medica- tion and had valid baseline and ≥1 on-treatment ...for efficacy endpoints were reported by treatment and concomitant ... See full document
5
Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial.
... this trial, is the targeting of onchocerciasis with anti-wolbachial ...of 4–6 week courses of treatment. Trials to evaluate the minimum effective course of treatment with combinations of ... See full document
14
Effect of herbal extract granules combined with probiotic mixture on irritable bowel syndrome with diarrhea: study protocol for a randomized controlled trial
... well-designed randomized controlled trials related to herbal medicine, and its mechanisms have been poorly ...will evaluate the efficacy of GJS, a representative herbal for- mula that has long ... See full document
8
Ustekinumab: differential use in psoriasis
... and 4, and every 12 weeks thereafter) or placebo at weeks 0 and 4, and subsequent crossover to ustekinumab at week 12, with half receiving 45 mg injections and the other half receiving ... See full document
7
A neuromuscular exercise programme versus standard care for patients with traumatic anterior shoulder instability: study protocol for a randomised controlled trial (the SINEX study)
... the 12- week, 1 and 2-year follow-ups: patient-reported numbers of visits to the general practitioner or secondary health care system during and after the end of intervention, number of shoulder ... See full document
10
USING BREWER’S YEAST AND GINGER IN THE MANAGEMENT OF CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME: A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED TRIAL
... Although the pathogenesis of IBS still unclear, evidence proved a strong relation with stress, abnormal intestinal motility, diet, and gut microbiota [38]. Stress was found to be an important factor that can disrupt ... See full document
5
Advances in the treatment of relapsing–remitting multiple sclerosis – critical appraisal of fingolimod
... in clinical practice, DMDs or immunosuppressive treat- ments are frequently associated with suboptimal response in terms of efficacy. The existing medications are only partially effective in halting MS relapses ... See full document
13
<p>Profile of plecanatide in the treatment of chronic idiopathic constipation: design, development, and place in therapy</p>
... Abstract: Constipation is a multifactorial disorder that can cause significant psychological distress to patients and economic burden on the health care ...of irritable bowel syndrome with ... See full document
6
A phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI 03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC)
... Safety will be monitored through weekly contact: tele- phone calls during weeks 1 and 3 and office visits during weeks 2 and 4. All adverse events will be recorded. The investigator will determine both the ... See full document
7
A 14 week randomized, placebo controlled, double blind clinical trial to evaluate the efficacy and safety of ginseng polysaccharide (Y 75)
... Y-75), 4 infections (1 with placebo and 3 with Y-75), 3 complaints of musculoskeletal system pain (1 with placebo and 2 with Y-75); 2 headaches, 1 case of fatigue, and 1 foreign body aspiration in the Y-75 group; ... See full document
7
Management of insomnia in elderly patients using eszopiclone
... Of the 264 patients randomized, 255 completed the study. Patients receiving eszopiclone 2 mg showed signifi- cant improvement in LPS, SE and TST (P , 0.001) by PSG compared with placebo. On PSG, it was noted that ... See full document
8
Duloxetine in the management of chronic musculoskeletal pain
... Therapy with duloxetine has also been reported for other chronic musculoskeletal conditions. Two mentally healthy young Asian women aged 32 and 27 years, each with tennis elbow of about 18 months duration, continued to ... See full document
11
Neuropathic pain responds better to increased doses of pregabalin: an in-depth analysis of flexible-dose clinical trials
... were assigned to a specific fixed dose prior to treatment with the dose response being shown for a population of patients. Here, for the first time, this analysis shows that this dose response also exists for ... See full document
8
Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management.
... 47. Soh JS, Lee HJ, Jung KW, Yoon IJ, Koo HS, Seo SY, et al. The diagnostic value of a digital rectal examination compared with high-resolution anorectal manometry in patients with chronic constipation and fecal ... See full document
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