[PDF] Top 20 Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis

... focal epilepsy candidate genes 15 (table e-1, ...focal epilepsy, 16 we curated additional gene sets by considering those of psychiatric disorders and of important neuronal functions (table e-2, ... See full document

... left hippocampal volume (volume ratio of the hippocampus and controls, ...left hippocampal volume correlated with structural connectivity positively (standardized ␤ ⫽ ...the hippocampal volume did ... See full document

... Over the past decade, extensive research on lncRNAs has increased our understanding of their diverse structural and regulatory func- tions in various biological processes. In epilep- sy, however, there are limited ... See full document

... of hippocampal abnormalities must be as fast and practical as ...optimized hippocampal quantification protocol can be easily applied to all patients with drug-resistant focal epilepsies as a parallel and ... See full document

... In an fMRI study of the effects of attempted naming on word retrieval in two patients with anomic aphasia, picture naming performance improved after multiple presentations over a period of days. At the neural level, the ... See full document

... global hippocampal volume on MRI is a sensitive marker of pathology in patients with mesial temporal lobe epilepsy (mTLE) and Alzheimer’s disease in particular, as an extensive ... See full document

... Against Epilepsy 2001 classification based on a comprehensive evaluation, includ- ing seizure history and semiology, neurologic examination, diag- nostic MR imaging, and electroencephalography records in all ... See full document

... than mesial temporal sclerosis; 2) focal ictal temporal lobe patterns recorded with scalp-sphenoidal EEG or mesial temporal seizure onset in patients requiring subdural or ... See full document

... left temporal lobe ...underwent temporal lobectomy and 11 had PET ...with mesial temporal sclerosis (one of which also showed contralateral hippocampal volume loss), two ... See full document

... of temporal- and ...cortex, temporal, lateral neocortex, as well as of the prefrontal, orbitofrontal, and mesial-frontal cortex, and to a lesser degree, of the tha- lamic nuclei and basal ganglia ... See full document

... anxiety, epilepsy, stroke, Alzheimer’s disease, and spinal cord injuries [13, ...of epilepsy induced by ...in epilepsy patients [17], which identified a role for t-PA in the mechanisms of underlying ... See full document

... left temporal region (Fig ...weekly de- spite combination treatment with val- proate, zonisamide, and ...left mesial temporal lobe were selected in- stead of amygdalohippocampectomy to ... See full document

... sclerotic hippocampal measurements, when compared with those in healthy ...unilateral hippocampal sclerosis, as shown on brain MR images, and the other factor relates to the selection of the ROI from ... See full document

... on epilepsy have focused on the epileptogenic zone, epilepsy is a system-level disease characterized by aberrant neuronal synchronization among groups of ...that mesial temporal lobe ... See full document

... Abstract. Hippocampal sclerosis (HS) is one of the most common histopathological abnormalities encountered in patients with temporal lobe epilepsy (TLE), which often serves as a ... See full document

... knowledge that depression and physiosomatic symptoms are accompanied by increased oxidative stress including lipid peroxidation and aldehyde formation and lowered antioxidant defenses as well [73-75]. Previously, a ... See full document

... The cerebrum is the most common location of tubers, predominantly (90%) in the frontal lobes. Tubers typically appear as areas of increased signal intensity in the cortical and subcortical regions on T2-weighted and ... See full document

... involves temporal lobectomy in cases of documented tem- poral lobe pathology, or lesionectomy in cases in which the epileptogenic lesion is completely apparent (ie, clear MRI findings and EEG monitoring ... See full document

... excluding variants in known developmental disorder genes, rare variants contribute a greater degree to schizophrenia risk in the SCZ-ID subgroup of patients than the remaining schizophrenia ...that ... See full document

... of hippocampal and amygdalar volume reduction on postoperative change in memory performance with Spearman ...left-sided hippocampal reduction in the SAHE group was associated with a decrease in verbal ... See full document