Top PDF Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion
Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion
... Detection of SVV DNA in ganglia, lungs, and lymph nodes from rhesus ma- caques after zoster. Ganglia from the side of the neuraxis opposite to those used for immunofluorescence analysis were used for DNA ...
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Simian Varicella Virus Is Present in Macrophages, Dendritic Cells, and T Cells in Lymph Nodes of Rhesus Macaques after Experimental Reactivation
... Determination of anti-SVV antibody levels. Anti-SVV antibody ti- ters in serum obtained from all monkeys before and after varicella and at necropsy were determined using a plaque reduction assay as ...
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Antibody-Mediated CD4 Depletion Induces Homeostatic CD4+ T Cell Proliferation without Detectable Virus Reactivation in Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Infected Macaques
... immunodeficiency virus (HIV) eradication is the long-term persistence of latently infected CD4 ⫹ T cells harboring integrated replication-competent ...of virus reactiva- tion, thus avoiding ...
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Age and Immune Status of Rhesus Macaques Impact Simian Varicella Virus Gene Expression in Sensory Ganglia
... VZV reactivation, increases in the immunocompromised and the ...of T cell- mediated immunity, whether due to age (immunosenescence), disease (HIV infection and hematological malignancies), or im- ...
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CD4+ CCR5+ T-Cell Dynamics during Simian Immunodeficiency Virus Infection of Chinese Rhesus Macaques
... transient depletion of peripheral CD4 ⫹ CCR5 ⫹ T cells observed in our group of Chinese RMs at the time of peak viremia could be explained in several ...of CD4 ⫹ T cells expressing ...
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Genome-Wide Analysis of T Cell Responses during Acute and Latent Simian Varicella Virus Infections in Rhesus Macaques
... glycoproteins. T cell responses directed against these ORFs account on average for 75% of the total SVV- specific BAL fluid-resident T cell ...positive T cell responses in the ...
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Effect of B-Cell Depletion on Coreceptor Switching in R5 Simian-Human Immunodeficiency Virus Infection of Rhesus Macaques
... of rhesus macaques with R5 SHIV SF162P3N effec- tively depleted CD20 ⫹ B cells and blunted the development of virus-specific antibody responses, it did not favor the emer- gence of X4 using viral ...
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Increased cellular immune responses and CD4+ T cell proliferation correlate with reduced plasma viral load in SIV challenged recombinant simian varicella virus simian immunodeficiency virus (rSVV SIV) vaccinated rhesus macaques
... of rhesus macaques with recombinant simian varicella virus (rSVV) vector – simian immunodeficiency virus (SIV) envelope and gag genes, induced neutralizing antibodies and ...
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Impact of Cytotoxic-T-Lymphocyte Memory Induction without Virus-Specific CD4+ T-Cell Help on Control of a Simian Immunodeficiency Virus Challenge in Rhesus Macaques
... eliciting virus-specific T-cell responses, whether induction of these memory T cells by vaccination before human immunodeficiency virus (HIV) exposure can actually contribute to ...
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Distinct Cycling CD4+- and CD8+-T-Cell Profiles during the Asymptomatic Phase of Simian Immunodeficiency Virus SIVmac251 Infection in Rhesus Macaques
... of CD4 ⫹ and CD8 ⫹ T cells in the LNs were calculated by multiplying the percentage of CD4 ⫹ and CD8 ⫹ T cells, as assessed by flow cytometry, by the number of cells retrieved from one ...
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Abortive Intrabronchial Infection of Rhesus Macaques with Varicella-Zoster Virus Provides Partial Protection against Simian Varicella Virus Challenge
... Our observations are consistent with those of previous studies demonstrating that VZV inoculation of nonhuman primates pro- vides partial protection against SVV challenge (57, 85). In one study, patas monkeys ...
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Intrabronchial Infection of Rhesus Macaques with Simian Varicella Virus Results in a Robust Immune Response in the Lungs
... by T cells and ...of CD4 and CD8 T cells during acute SVV infection, and these data will contribute to the development of more efficacious vaccines that can boost protective T cell re- ...
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Differential CD4+ T-Lymphocyte Apoptosis and Bystander T-Cell Activation in Rhesus Macaques and Sooty Mangabeys during Acute Simian Immunodeficiency Virus Infection
... ⴙ T-lymphocyte apoptosis, temporally coinciding with onset of SIV- specific cellular immunity, and elevated plasma Th1 cytokine and gamma interferon-induced chemokine levels were common to both SM and ...ⴙ ...
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Gut Mucosal FOXP3+ Regulatory CD4+ T Cells and Nonregulatory CD4+ T Cells Are Differentially Affected by Simian Immunodeficiency Virus Infection in Rhesus Macaques
... mucosal T reg is most pronounced after SIV- induced depletion of mucosal CD4 ⴙ T ...mucosal T reg during the course of SIV infection, we immunohistochemically examined the ...
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Multigene DNA Priming-Boosting Vaccines Protect Macaques from Acute CD4+-T-Cell Depletion after Simian-Human Immunodeficiency Virus SHIV89.6P Mucosal Challenge
... Lymphocyte depletion following viral challenge. Three weeks after the fifth immunization, all animals were challenged intrarectally with 50 AID 50 of ...all macaques were measured over the course of ...
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Membrane-Fusing Capacity of the Human Immunodeficiency Virus Envelope Proteins Determines the Efficiency of CD4+ T-Cell Depletion in Macaques Infected by a Simian-Human Immunodeficiency Virus
... pleted CD4 ⫹ T lymphocytes at a given level of in vivo repli- ...vivo CD4 ⫹ T-cell- depleting ability may be greater than that ...tween CD4 ⫹ T lymphocyte depletion ...
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The Simian Immunodeficiency Virus Δnef Vaccine, after Application to the Tonsils of Rhesus Macaques, Replicates Primarily within CD4+ T Cells and Elicits a Local Perforin-Positive CD8+ T-Cell Response
... from simian immunodeficiency virus (SIV) strain SIVmac239 yields a virus that undergoes attenuated growth in rhesus macaques and offers substantial protection against a subsequent ...
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Effect of CD8+ Lymphocyte Depletion on Virus Containment after Simian Immunodeficiency Virus SIVmac251 Challenge of Live Attenuated SIVmac239Δ3-Vaccinated Rhesus Macaques
... that rhesus monkeys expressing certain MHC class I alleles, such as Mamu-A*01, can control SIV replication more effectively than animals not expressing this allele (39, 41, 42), possibly due to the generation of ...
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Transcriptional Profiling of Experimental CD8+ Lymphocyte Depletion in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239
... ⴙ T cells inhibit virus replication in SIV-infected rhesus ...ⴙ T cells reflects direct killing of infected cells as opposed to indirect, noncytolytic ...SIVmac239-infected rhesus ...
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Depletion of CD4+ T cells abrogates post peak decline of viremia in SIV infected rhesus macaques
... B cell responses in CD4 + lymphocyte–depleted RMs compared with con- ...residual CD4 + T cells present in deplet- ed SIV-infected RMs may have been sufficient to provide the required help for ...
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