K 2 CO 3 /
Scheme 35. Reaction of enaminone 147 with hydrazine hydrate and hydroxylamine.
Compound 147 reacts with active methylene compounds and yielded the regioisomeric linked thiadiazole pyridine structures represented by either 151 or 153. Two pathways are outlined in (Scheme 36) for this reaction. The reaction may proceed by initial Michael addition (route A) of the active methylene compound to the activated double bond of 147 to give the Michael adduct 150 followed by tandem elimination of dimethylamine and condensation with ammonia to give product or the other suggested pathway (route B) may proceed by initial condensation of active methylene compound with the carbonyl group of 147 which leads to formation of intermediate 152 that cyclizes in the presence of ammonium acetate to give 153.
4- Synthesis of new 1,2,4-tri and 1,3,4-thiadiazoles were prepared by Khosrow et al. 10 This synthesis bearing isomeric pyridyl and 1-naphthyl is reported using 1,4- disubstitutedhiosemicarbazides in alkaline and acidic media, respectively. The methylthio and benzylthio derivatives of the synthesized triazoles are also reported. All of the synthesized compounds were characterized by their FT-IR, 1H-NMR and mass spectral data. The antibacterial studies of some of the synthesized compounds against S. aureus and E. coli as MIC values are reported.
The synthetic creativity in the heterocycle preparation systems provides suitable opportunities to explore new drug-pertinent chemical scope. It is possible to enhance the diversity of the molecules that medical researchers in paralleled medicinal chemistry can prepare through robust heterocycle syntheses and functionalizations. This can also enhance the design-synthesis-screen sequence times in the pre-clinical research and the productivity of drug discovery. This study focused on the worth of academic-industrial collaboration during the development of new synthetic methodologies about the medicinally suitable heterocycles. In addition, the advancements in small chemistry that occur before the preparation of 1, 2, 3-triazoles to discover diverse heterocyclic scaffolds will
2003; Andrade et al. 2004; Gutz 2006; Fatibello-Filho 2007). Beside this influence—the financial support of the Brazilian agencies and the SBQ’s support—the well-established graduate programs in analytical chemistry spread through Sa˜o Paulo State have also exerted a strong contribution to the evolution of electroanalytical chemistry. Apart from the Sa˜o Paulo State, there is a strong dissemination of electroanalytical widespread throughout the country and other states such as Rio de Janeiro (6.0%), Paran a a (3.6%), Rio Grande do Sul (3.2%), Maranha˜o (2.6%), Paraı´ba (2.5%), Pernambuco (2.4%), Minas Gerais (2.1%), Santa Catarina (1.0%), and Sergipe (1.0%) have also contributed in the last decades. Each one of the states of Mato Grosso, Bahia, Mato Grosso do Sul, Goi a as, Cear a a, Alagoas, Rio Grande do Norte, Piauı´, and Amazonas have contributed with a percentage smaller than 1% (Fatibello-Filho 2007). The number of articles in chemistry (all areas) published in Quı´mica Nova in the period of 2000–2006 by the researchers of Sa˜o Paulo State was 549, which corresponds to 43.6% of the total articles published by Brazilian authors (Torresi et al. 2007). Data from specialized literature show a significant contribution from Brazilian electroanalytical chemists in high-impact periodicals, and there is a very good adherence among works carried out in Brazil and abroad, according to a comparison of works presented in the 14th Brazilian Meeting on Analytical Chemistry (Joa˜o Pessoa=PB, October 2007) and the XIV European Conference on Ana- lytical Chemistry (Antwerp=Belgium, September 2007) (Fatibello-Filho 2007). In a similar study published five years ago regarding adherence, the same conclusions were reached (Fatibello-Filho et al. 2002), which was reinforced by Zagatto and S a a (Zagatto and S a a 2003).
The issue before the court was whether the denial of Topps’ prior petition acted as a procedural bar to the current action. More specifi- cally, the court addressed whether Topps’ subsequent petition was barred by res judicata or collateral estoppel. Res judicata and collat- eral estoppel are related but different concepts. 240 Res judicata is a doctrine that bars relitigation in a subsequent cause of action for claims that were raised and claims that could have been raised. 241 In Florida, “res judicata applies when four identities are present: (1) identity of the thing sued for; (2) identity of the cause of action; (3) identity of persons and parties to the action; and (4) identity of the quality of the persons for or against whom the claim is made.” 242 The
US growth momentum is expected to be maintained for the rest of the year. Leading
indicators such as the ISM manufacturing PMI increased to 59.0 in October from 56.6 in September, supported by stronger employment. While the October non-manufacturing PMI retreated to 57.1 from 58.6 the month before, it remained firmly in expansionary territory. Recent data also suggest that a more sustainable recovery is taking place in the labour market—employment growth averaged 751,000 over Q2 and Q3 2014, compared to 583,000 in 2013. While payroll increases slowed to 214,000 in October, this outcome is still consistent with a steady underlying improvement in labour demand, even as businesses’ investment spending is expected to stay firm. Higher investment is in turn predicated on continued growth in household spending—the University of Michigan Consumer Sentiment Index rose for the fourth consecutive month to 89.4 in November. However, the Conference Board Consumer Confidence Index in November retreated to 88.7 from 94.1 the month before, as consumers moderated their optimism. Even so, income expectations
India’s GDP growth eased in Q4 2015, alongside slowing fixed investment. Overall growth dipped to 7.3% y-o-y in Q4 from 7.7% in the previous quarter, as weaker investment growth more than offset a pickup in private consumption. India’s investment recovery lost momentum, with gross fixed capital formation growth retreating to 2.8% y-o-y in Q4 from 7.6% the quarter before, largely due to weak private capital spending. However, household consumption expanded by 6.4% y-o-y in Q4, with firm urban spending more than compensating for weak rural demand. Meanwhile, net exports contributed positively to overall growth, after posing a slight drag in the preceding two quarters, as the contraction in imports outpaced the fall in exports. Looking ahead, the Indian economy should remain on a modest recovery path, supported by low energy prices and accommodative monetary conditions. Nonetheless, risks to growth are skewed to the downside amid a weaker global environment and potential financial stability concerns stemming from fragile bank and corporate balance sheets. All in, GDP growth is expected to come in at 7.4% in FY2016 1 , picking up further to 7.7% the following year.
186. “Services” can also be interpreted broadly. There seems to be little that would not arguably be a service during a disaster—repairs to property, answering telephones, dis- tributing food, and so on. Again, the statute and the staff report supply little guidance— the staff report merely acknowledges that immunity for “services” is broader than the im- munity provided by the rest of the statute. See Fla. S. Comm. on Comp. Plan. & S. Comm. on Health, Aging, & Long-Term Care, CS for CS for SB 532 (2004) Staff Analysis 4 (Mar. 8, 2004) (on file with comm.) [hereinafter Comp. Plan. & Health, Aging, & Long-Term Care Staff Analysis] (stating that the amendment “provides immunity from liability to a person who provides ‘services’ during emergency response activities, in addition to medical treat- ment”).
jority, however, decided that the definition was not imprecise and that it could construe a definition of “municipal or public purposes” for the purposes of ad valorem tax exemption in article VII, section 3(a). Based on precedent, the majority concluded the phrase requires that the government activity is “essential.” It then found that tele- communications services do not necessarily constitute essential ser- vices and rejected the facial challenge to the statutes at issue. As the First District and the dissent noted, however, whether “municipal or public purpose” requires that the government activity is essential is debatable, and whether telecommunications services are essential if such a definition is imposed is also debatable. The case leaves uncer- tain what government services will continue to constitute a “munici- pal or public purpose” in order to be exempt from ad valorem taxa- tion and may affect municipal decisions dealing with the provision of public services.
69. Kelo II, 125 S. Ct. at 2659. Parcel 1 is designated for a waterfront conference hotel that will include restaurants, shopping and marinas; Parcel 2 will have eighty new resi- dences and space for a new U.S. Coast Guard Museum; Parcel 3 is located immediately north of the Pfizer facility with 90,000 square feet of research and development office space; Parcel 4A will be used to either support the adjacent state park with parking or re- tail services or to support the marina; Parcel 4B will include a renovated marina and the final stretch of the riverwalk; Parcels 5, 6, and 7 will provide land for office and retail space, parking and water-dependent commercial uses. Id.
(1) A person who uses force as permitted in s. 776.012, s. 776.013, or s. 776.032 is justified in using such force and is immune from criminal prosecu- tion and civil action for the use of such force, unless the person against whom force was used is a law enforcement officer, as defined in s. 943.10(14), who was acting in the performance of his or her official duties and the officer identified himself or herself in accordance with any applicable law or the person using force knew or reasonably should have known that the person was a law en- forcement officer. As used in this subsection, the term “criminal prosecution” includes arresting, detaining in custody, and charging or prosecuting the de- fendant.
(e)(1) No court, justice, or judge shall have jurisdiction to hear or consider an application for a writ of habeas corpus filed by or on behalf of an alien detained by the United States who has been determined by the United States to have been properly detained as an enemy combatant or is awaiting such determination. (2) Except as provided in paragraphs (2) and (3) of section 1005(e) of the De- tainee Treatment Act of 2005 (10 U.S.C. 801 note), no court, justice, or judge shall have jurisdiction to hear or consider any other action against the United States or its agents relating to any aspect of the detention, transfer, treatment, trial, or conditions of confinement of an alien who is or was detained by the United States and has been determined by the United States to have been properly detained as an enemy combatant or is awaiting such determination.
then rejected the Government’s provided explanations for why the military commissions and courts-martial courts differed. Further, the Court avoided the question of whether any provision of Commission Order No. 1 was contrary to the UCMJ by concluding that the Presi- dent had not provided a sufficient explanation of why uniformity be- tween courts-martial and military commission proceedings was not practicable. 44 In particular, the Court focused on the exclusion of the
Recent developments in breastfeeding Med J Malaysia Vol 41 No 1 March 1986 RECENT DEVELOPMENTS IN BREASTFEEDING DERRICK B JELLlFFE SUMMARY Recent developments in breastfeeding are reviewed in relation[.]
Interestingly, responses to most JAK2 inhibitors have been independent of underlying disease, ie, primary MF, post-PV/ET MF, or JAK2V617F mutation status. Withdrawal of JAK inhibitors predictably results in splenic growth, symp- tomatic relapse, and, at times, hemodynamic instability. With long-term safety still under investigation, patients need to be followed closely. It has been suggested that slow tapering over a 2–4-week period may mitigate a “cytokine-flare” that occurs with abrupt withdrawal.
Instead, it found it justifiable that the employer had felt ‘bullied’ by the trade union to employ the claimants and had, in response, decided to ‘dig his heels in’. The EAT agreed with the tribunal’s finding by applying the ‘because of’ test drawn from discrimination law in order to elucidate the employer’s principal reason for not employing the claimants. In addition, the EAT required trade union activities to have formed at least part of the employer’s motivation (whether consciously or subconsciously) in not hiring the claimants. In its analysis, the EAT found that the employer’s principal motivation was driven by the pressure placed on it by the trade union rather than the claimants’ union activities. The EAT’s decision is interesting for two reasons. First, the tribunal in effect widened the scope of regulation 3 by accepting that a ‘mental list’ could be sufficient for the Regulations to apply. Second, the EAT has provided an indication of what it may accept as a ‘reasonable explanation’ by an employer in order to prevent a breach of the Regulations. The burden of proof in the Regulations is effectively reversed meaning that if there are facts from which a tribunal can infer that the employer breached the general prohibition contained in regulation 3 and in the absence of a reasonable explanation, the tribunal should find that the employer had acted in contravention of the Regulations. In Miller, the EAT recognised the employer’s feelings of ‘bullying’ as a reasonable explanation for the use of a list prohibited under regulation 3. Such acceptance of a margin of subjectivity in favour of the employer will make it difficult for workers to rely on the Regulations in the absence of specific proof that an employer refused employment on the grounds of trade union activities. However, as blacklisting is by its very nature a covert act which is difficult to prove, this in effect puts into doubt the added value of the Regulations.
This paper gives an overview of recentdevelopments in the German Reference Corpus DRK in terms of growth, maximising relevant corpus strata, metadata, legal issues, and its current and future research interface. Due to the recent acquisition of new licenses, DRK has grown by a factor of four in the ﬁrst half of 2014, mostly in the area of newspaper text, and presently contains over 24 billion word tokens. Other strata, like ﬁctional texts, web corpora, in particular CMC texts, and spoken but conceptually written texts have also increased signiﬁcantly. We report on the newly acquired corpora that led to the major increase, on the principles and strategies behind our corpus acquisition activities, and on our solutions for the emerging legal, organisational, and technical challenges.
Another factor every employer involved in litigation should consider is the average time a case takes to litigate from the time an allegation is made to the time the case is settled or goes to trial. Recent statistics from the federal district courts show that the average life cycle of a civil case litigated through to trial is 23.2 months. In the Western District of Missouri, that period is slightly higher at 23.9 months and slightly lower in the Eastern District at 21.7 months. Similarly, cases litigated to trial in Kansas federal courts only average 19.5 months in duration. III. Employee Non-Compete Agreements
If the persistence cannot be accounted for linearly, a second possibility is that it stems from threshold dynamics related to excessive debt. For example, Leybourne et al. (1998) and Nelson et al. 2001 ﬁnd that such non-linear dynamics can give rise to the appearance of stochastic trending. To study this possibility, we use the debt measures as transition variables in nonlinear regime-switching models for the credit loss rates. The idea is to capture increases in the interaction between credit losses and the business cycle which may arise if aggregate debt is allowed to reach excessive levels (see e.g., Miller and Stiglitz (2010)). The reason is that borrowers who are at the limits of their credit constraints may not be able to smooth their consumption or make optimal investments as they have to honor their debt obligations in the wake of a negative shock. Campello et al. (2010), for example, document signiﬁcant changes in the investment and employment decisions of credit constrained ﬁrms during the recent ﬁnancial crisis. If the proportion of constrained borrowers is large, this type of behavior can easily reinforce the negative effects of the initial shock, thereby creating increased feedback between loan defaults and the business cycle. An additional beneﬁt of this modeling strategy is that it allows us to estimate a critical threshold for each debt variable above which it becomes excessive, provided that nonlinear transition-dynamics are present 8 .