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[PDF] Top 20 T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia

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T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia

T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia

... for beta rearrangements ...in T-ALL. However, in pre-B ALL the pattern of gamma TCR usage was distinct from that of T cells, with the C gamma 1 complex utilized more ...as ... See full document

13

Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia

Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia

... lymphoblastic leukemia (T-ALL) and in three CD3- leukemic T cell lines (HSB2, CEM, and ...TCR-alpha, beta, and gamma genes was examined in 11 of these ... See full document

9

B cell origin of non T cell acute lymphoblastic leukemia  A model for discrete stages of neoplastic and normal pre B cell differentiation

B cell origin of non T cell acute lymphoblastic leukemia A model for discrete stages of neoplastic and normal pre B cell differentiation

... of B cell associated and restricted antigens on tumor cells isolated from 138 patients with non-T cell acute lymphoblastic leukemia (non-T cell ALL) was ... See full document

10

Rearrangement of variable region T cell receptor gamma genes in acute lymphoblastic leukemia  V gamma gene usage differs in mature and immature T cells

Rearrangement of variable region T cell receptor gamma genes in acute lymphoblastic leukemia V gamma gene usage differs in mature and immature T cells

... (V gamma) and joining regions (J gamma) of the T cell receptor (TCR) gamma gene, we have analyzed the usage of V gamma genes in 24 patients with T ... See full document

8

T cell receptor delta gene rearrangements in acute lymphoblastic leukemia

T cell receptor delta gene rearrangements in acute lymphoblastic leukemia

... analyzed T cell receptor (TCR) delta gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and 29 patients with ... See full document

10

The potential of CAR T therapy for relapsed or refractory pediatric and young adult B-cell ALL

The potential of CAR T therapy for relapsed or refractory pediatric and young adult B-cell ALL

... antigen receptor (CAR) T cells, which have revolutionized the treat- ment of pediatric patients with relapsed or refractory B-cell acute lymphoblastic ...CAR T-cells are ... See full document

12

T cell receptor alpha chain gene rearrangements in B precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia  Comparative study of T cell receptor gene rearrangement in childhood leukemia

T cell receptor alpha chain gene rearrangements in B precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia Comparative study of T cell receptor gene rearrangement in childhood leukemia

... both gamma- and beta-chain genes, whereas the remaining six had no rearrangements of gamma- and beta-chain ...that alpha- chain gene rearrangement is not specific for T ... See full document

9

The molecular basis of T cell acute lymphoblastic leukemia

The molecular basis of T cell acute lymphoblastic leukemia

... three genes encoding bHLH factors closely related to TAL1, are translocated and aberrantly expressed in rare cases of T-ALL ...of T-ALL in transgenic mice expressing TAL1 in developing thymocytes ... See full document

10

Acute leukemia expressing the gamma gene product of the putative second T cell receptor

Acute leukemia expressing the gamma gene product of the putative second T cell receptor

... the T gamma gene product in association with the CD3(T3) complex have recently been ...human acute lymphoblastic leukemia with a CD2+, CD3+, CD4-, CD5+, CD7+, CD8-, WT31- ...have ... See full document

5

Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China

Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China

... powerful pre- dictors of treatment outcome in childhood ALL [7 – ...[12–15]. T- ALL patients are more likely to have a worse steroid re- sponse than B-ALL patients [8, 10, ...established ... See full document

11

Rearrangement of the genes for the beta and gamma chains of the T cell receptor is rarely observed in adult B cell lymphoma and chronic lymphocytic leukemia

Rearrangement of the genes for the beta and gamma chains of the T cell receptor is rarely observed in adult B cell lymphoma and chronic lymphocytic leukemia

... the genes for the beta (T beta) and gamma (T gamma) chains of the T cell receptor in DNA from 100 consecutive cases of B cell lymphoma ... See full document

7

MYC as therapeutic target in leukemia and lymphoma

MYC as therapeutic target in leukemia and lymphoma

... of leukemia and ...in acute lymphoblastic leukemia, acute myeloid leukemia, lymphoproliferative, and myeloproferative diseases, they are less ...in leukemia-derived cells ... See full document

17

Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia

Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia

... et al characterized the cellular accumulation of ara-GTP and the related clinical response elicited in patients diagnosed with various hematologic malignancies including T-ALL, CML-BC (chronic myeloid ... See full document

10

Peripheral immune-based biomarkers in cancer immunotherapy: can we realize their predictive potential?

Peripheral immune-based biomarkers in cancer immunotherapy: can we realize their predictive potential?

... programmed cell death protein 1 (PD-1) on CD4 + and natural killer (NK) cells than non- responders after the first cycle of anti-PD-1 immuno- therapy, with lower expression of T-cell CTLA-4, ... See full document

14

Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia

Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia

... and acute renal failure (ARF) before the initiation of ...of cell turnover (eg, Burkitt’s lymphoma) and has only rarely been described in the pediatric ... See full document

6

Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia

Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia

... CAR T infusion [51, ...high leukemia burden are at increased risk of more se- vere CRS, presenting as vascular leak and hypotension leading to multi-organ system ...CAR T cell activ- ...CAR ... See full document

13

Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

... Adoptive T cell transfusion using cancer antigen-specific T cells is the most effective immunotherapy ...antigen-specific T cells for each pa- tient in vitro in a short period of time, and ... See full document

8

CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

... The autologous material from leukapheresis is then shipped to a manufacturing facility. Novartis has currently two facilities to produce CTL019, one in Morris Plains, NJ, USA and the other in Leipzig, Germany. UPenn ... See full document

14

xCELLigence system for real-time label-free monitoring of growth and viability of cell lines from hematological malignancies

xCELLigence system for real-time label-free monitoring of growth and viability of cell lines from hematological malignancies

... each cell model may exhibit different cell behavior in the presence of several coating ...maximum B-CI reached by two cell lines may be completely different (depending on cell size, ... See full document

10

Acute B-Cell Lymphoblastic Leukemia/Acute B-Cell Lymphoblastic Lymphoma Presenting as Bilateral Breast Masses

Acute B-Cell Lymphoblastic Leukemia/Acute B-Cell Lymphoblastic Lymphoma Presenting as Bilateral Breast Masses

... Case Report: A thirty-year-old woman has applied to our department with a four month story of painless masses in both of breasts. We have performed tru-cut biopsies to both breasts after clinical examination. ... See full document

5

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