[PDF] Top 20 Regeneration of the pancreatic β cell
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Regeneration of the pancreatic β cell
... of regeneration can continue efficiently, eventually replenishing the population of insulin-producing cells to a number sufficient to maintain euglycemia, thus curing the diabetic recipi- ent (Figure 2D) ...the ... See full document
9
Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control
... stem cell biology suggest that a sustainable treatment approach to cure diabetes mellitus (DM) can be achieved in the near ...for β -cell regeneration. These β cell-specific ... See full document
12
Combined modulation of polycomb and trithorax genes rejuvenates β cell replication
... functional β cell mass underlies both type 1 and type 2 diabetes. β Cell growth and regeneration also decrease with age through mechanisms that are not fully ...adult β ... See full document
11
Targeted Epigenetic Editing to Increase Adult Pancreatic Β-Cell Proliferation
... of pancreatic islet transplantation in type 1 ...human β-cells for transplantation in type 1 diabetics, or to increase residual β-cell mass in type 2 diabetics, is to induce human ... See full document
144
The cell cycle as a brake for β-cell regeneration from embryonic stem cells
... of β cells is regulated by a network of tightly orchestrated cell cycle ...of β cells to replicate at different life stages [53–56]. Cell cycle progression in murine islets is controlled by ... See full document
9
Recovery from diabetes in mice by β cell regeneration
... of pancreatic β cells. We reasoned that a useful model to study β cell regeneration would permit: (a) specific kill- ing of β cells; (b) temporal control over the onset of ... See full document
10
A CCR2+ myeloid cell niche required for pancreatic β cell growth
... sustain cell renewal after tissue damage is critical to the maintenance of organ function throughout ...tissue regeneration following injury (3–8). Loss of myeloid cell–driven tissue remodeling and ... See full document
22
Putting pancreatic cell plasticity to the test
... into β cells? If not, what other DNA-binding proteins need to be induced or suppressed? Because α cells are not destroyed in type 1 diabetes, this would provide a conceptually simple approach to therapeutically ... See full document
5
Development of a conditionally immortalized human pancreatic β cell line
... and β cells (23, 24) and primate hepatic progenitor cell lines ...first β cell line developed with this approach rapidly lost insulin expression ...promising β cell–specific ... See full document
13
β1 integrin is a crucial regulator of pancreatic β cell expansion
... of cell differentiation is constantly at balance with mechanisms regulating cell ...the cell cycle that are controlled by both cell-autonomous and non- autonomous mechanisms of gene expression ... See full document
13
Extracellular Signals and Pancreatic β-cell Development: A Brief Review
... The Wnt genes encode a large family of secreted glycoprotein growth factors (19 in humans) (71). The Wnt genes are highly conserved between verte- brates, sharing overall sequence identity. Once se- creted, Wnt proteins ... See full document
8
Xenotropic retrovirus Bxv1 in human pancreatic β cell lines
... from cell to cell in a petri dish leaves many noninfected cells even after several weeks; (c) propagation was not observed under nonoptimized conditions, such as addition of half-diluted ... See full document
6
glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
... of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic ...of cell fate acquisition and ...beta cell depletion, regenerating the form ... See full document
11
Lessons in human biology from a monogenic pancreatic β cell disease
... human β cell physiology is critical to our understanding of the pathophysiology behind both type 1 and type 2 diabe- ...of pancreatic tissue obtained from CHI patients dur- ing therapeutic ... See full document
6
Coenzyme Q10 suppresses apoptosis of mouse pancreatic β-cell line MIN6
... in cell lysis buffer containing a pro- tease inhibitor cocktail. The cell lysates (10 µg protein per sample) were then separated by ...and β-actin (1:1000 ... See full document
6
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration
... that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic efforts to increase insulin- producing b cell mass in patients ... See full document
8
Neuronatin regulates pancreatic β cell insulin content and secretion
... INS1E β cells (Supplemental Figure 5A) with high ...in pancreatic islets, while acute feeding with either high-fat diet or Western diet led to increased expression (Figure 6C and Supplemental Figure ...MIN6 ... See full document
14
Epigenomic plasticity enables human pancreatic α to β cell reprogramming
... treated β, technical replicates) and focused on cell-type–specific hormones and transcription ...Adox-treated β cells become more α cell like or vice versa, we first compared the ratio of ... See full document
11
Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes
... increased cell density ...increased cell density ...3. Pancreatic duct gland (PDG) cell replication is increased in the human-IAPP-transgenic (HIP) rat model of type 2 diabetes mellitus ...the ... See full document
15
Biochemical And Functional Studies Of Histone Deacetylase 3 In Metabolic Tissues
... in β-cells of adult mice. An HDAC3 β-cell specific knockout was generated using the MIP-CreERT transgenic mouse model and while HDAC3 β-cell specific deletion did not increase total ... See full document
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