[PDF] Top 20 Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
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Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
... in insulin binding and a parallel increase in insulin-stimulated receptor phosphorylation in muscle of fasting and streptozotocin-induced (STZ) diabetic ...overall receptor ... See full document
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Regulation of phosphatidylinositol 3 kinase activity in liver and muscle of animal models of insulin resistant and insulin deficient diabetes mellitus
... 90%. Insulin-stimulated total PI 3-kinase activity was also absent in both tissues of the ob/ob ...in muscle, IRS-1-associated PI 3-kinase activity was increased two- to threefold in liver and ... See full document
9
Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI ... See full document
9
High levels of dietary fat impair glucose homeostasis in rainbow trout
... the liver, it is either stored as glycogen or oxidised through glycolysis and the pentose phosphate pathway, and ultimately used for FA synthesis through ...the regulation of plasma glucose is more ... See full document
10
Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction
... unknown. Insulin signaling plays a key role in the regulation of glucose ...of insulin signaling pathways could be a potential contributor to acute hyperglycemia after ...and insulin levels ... See full document
9
Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... metabolic insulin resistance in NIDDM, elevated glu- cose levels are of predominant ...of insulin receptor function most likely contributes to hyperglyce- mia-induced insulin ... See full document
8
Glucocorticoid regulation of insulin receptor and substrate IRS 1 tyrosine phosphorylation in rat skeletal muscle in vivo
... glucocorticoid-induced insulin resistance might originate from abnormalities in insulin receptor signaling, we investigated the effects of glucocorticoids on in vivo tyrosine phosphorylation ... See full document
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...that insulin can act as a growth factor in ... See full document
7
The role of adipokines in skeletal muscle inflammation and insulin sensitivity
... skeletal muscle insulin sensitivity by impacting on the activity of components within insulin signalling pathways, affecting GLUT4 translocation and modulating insulin-mediated skeletal ... See full document
11
Expression and function of the insulin receptor substrate proteins in cancer
... The IRS proteins have been implicated in contributing to all stages of cancer, from initiating events to metastatic progression. However, there is still much to be learned about the mechanisms by which each of the IRS ... See full document
15
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... in insulin sensitivity after drug treatment during the ITT on day 3 (Kaiser, Warpman & James, ...on insulin sensitivity could be due to the inability of TSA to work through the molecular mechanism of ... See full document
14
Regulation of obesity and insulin resistance by hypoxia-inducible factors
... obesity-induced insulin resistance and further supports opposing roles of HIF-1 α and HIF-2 α in adipo- cyte glucose ...and insulin sensitivity, reduced NO production, and attenuated adipose ... See full document
13
Extracts from Salvia Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity
... Hepatic insulin resistance is also associated with activation of regulatory signaling ...interfering insulin signaling by competitively binding to the InsR, affecting IRS phosphorylation [17], or ... See full document
11
Tyrosine kinase signalling in breast cancer: Insulin like growth factors and their receptors in breast cancer
... The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian ...IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast ...kinase receptor, undergoes ... See full document
6
Stochastic and Optimization Programming for Blood Glucose & Insulin Regulatory Systems of Type-2 Diabetes
... Tables 1 and 2 it is observed that the glucose at time t is the increasing functions of the glucose arrival rate through food intake, liver, gluconeogenesis and lipogenolysis processes when all the ... See full document
8
Capsaicin in metabolic syndrome
... of insulin-secreting β-cell mass; this change augments glucose-stimulated insulin secretion ...improved insulin sensitivity in humans and rodents ...improved insulin secretion ... See full document
21
Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes
... for insulin receptor (IR) with FastStrat Universal SYBR Green Master (Roche) and primers (for- ward 5′-CGGCCAGAGGCTGAGAATAAT-3′, reverse 5′-CGCCATCTGAATCA ... See full document
8
Insulin receptor phosphorylation, insulin receptor substrate 1 phosphorylation, and phosphatidylinositol 3 kinase activity are decreased in intact skeletal muscle strips from obese subjects
... 0.9). Insulin- stimulated 2-deoxyglucose uptake was 53% lower in muscle strips from obese ...Additional muscle strips were incubated in the basal state or with 10(-7) M insulin for 2, 15, or ... See full document
11
Original Article Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice
... and insulin signaling, while positive associations of muscle FNDC5 with insulin resistance is ...on muscle insulin resistance is still ...on muscle insulin ... See full document
8
Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
... promote insulin resistance remain to be ...the insulin-sensitizing effects of TZDs in ...become insulin resistant (45), and it will be of interest to directly study insulin signaling in ... See full document
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