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[PDF] Top 20 Regulation of ventral midbrain patterning by Hedgehog signaling

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Regulation of ventral midbrain patterning by Hedgehog signaling

Regulation of ventral midbrain patterning by Hedgehog signaling

... developing ventral midbrain, the signaling molecule sonic hedgehog (SHH) is sufficient to specify a striped pattern of cell fates (midbrain ...how hedgehog (HH) signaling ... See full document

10

SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis

SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis

... We and others have found that taste buds are significantly reduced after 21 days of HPI treatment (Castillo-Azofeifa et al., 2017; Kumari et al., 2015, 2017; Yang et al., 2015); during 2-4 weeks of drug exposure, FFP of ... See full document

13

Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling

Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling

... Hh signaling might play a role in specifying different cell fates within the olig2 precursor ...echidna hedgehog (ehh), and floor plate expresses shh and tiggywinkle hedgehog (twhh) (Currie and ... See full document

11

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

... Hh signaling is commonly downregu- lated and may be reactivated only in certain types of cancer ...Hh signaling in adult tissues frequently shows activity gradients that are involved in maintenance of ... See full document

15

C2cd3 is required for cilia formation and Hedgehog signaling in mouse

C2cd3 is required for cilia formation and Hedgehog signaling in mouse

... Hh signaling plays key roles in the regulation of ventral spinal cord patterning, digit formation and patterning of the left-right axis (Hooper and Scott, 2005), all of which are ... See full document

10

Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling

Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling

... telencephalon patterning and differentiation are not well ...however, ventral telencephalic domains are smaller and dorsal domains are ...of ventral progenitors, similar to the role of ... See full document

11

Dorsoventral patterning of the Xenopus eye: a collaboration of
Retinoid, Hedgehog and FGF receptor signaling

Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling

... Hh signaling has a crucial role in OS ...Hh signaling by Shh knock out in mouse, smoothened knock out in zebrafish or cyclopamine treatments in Xenopus all cause suppression of OS fate, thus indicating that ... See full document

12

The CNS midline cells and spitz class genes are required for proper patterning of Drosophila ventral neuroectoderm

The CNS midline cells and spitz class genes are required for proper patterning of Drosophila ventral neuroectoderm

... receptor signaling pathway is required in the initial patterning of the entire VNE before gastrulation and later in the vicinity of the CNS midline cells during neurogenesis (Skeath, 1998; Udolph et ...the ... See full document

11

Dorsal Ventral Patterning and Gene Regulation in the Early Embryo of Drosophila melanogaster

Dorsal Ventral Patterning and Gene Regulation in the Early Embryo of Drosophila melanogaster

... BMP signaling, which activates genes in the dorsal most part of the embryo is also a candidate for repression of genes expressed in the neurogenic ...Dpp signaling (Stathopoulos and Levine, ...Dpp ... See full document

120

Signal dynamics in Sonic hedgehog tissue patterning

Signal dynamics in Sonic hedgehog tissue patterning

... Kinetic, diffusive and binding parameter values were either directly taken from the literature or estimated based upon analogous biological systems (Fig. 2 legend, see also Table S1 in the supplementary material). ... See full document

13

Splitting the Hedgehog signal: sex and patterning in
Drosophila

Splitting the Hedgehog signal: sex and patterning in Drosophila

... Hh signaling by Sxl requires the Hh cholesterol moiety, then signaling through just C84S-Hh might be predicted to induce ...Hh signaling (which normally also functions to grow the ...Dpp ... See full document

10

Temporal requirement for hedgehog signaling in ventral telencephalic patterning

Temporal requirement for hedgehog signaling in ventral telencephalic patterning

... of hedgehog (Hh) signaling in neural development has been studied in the developing mammalian spinal cord, and it is now clear that Hh proteins are an essential part of ventral neural ... See full document

10

Ocular vessel patterning in zebrafish is indirectly regulated by Hedgehog signaling

Ocular vessel patterning in zebrafish is indirectly regulated by Hedgehog signaling

... Hh signaling because it has been shown to positively regulate VEGF signaling in several contexts and it also influences eye ...Hh signaling affected superficial vessel development we used smoothened ... See full document

9

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

... of ventral midbrain cells arising from progenitors that express either Shh or Gli1 at dif- ferent developmental time points, we were able to estab- lish a detailed quantitative assessment of the ... See full document

20

brother of cdo (umleitung) is cell autonomously required for Hedgehog mediated ventral CNS patterning in the zebrafish

brother of cdo (umleitung) is cell autonomously required for Hedgehog mediated ventral CNS patterning in the zebrafish

... the ventral midbrain (arrowhead in K), hindbrain (bracket in K) and in the ventral half of the spinal cord (bracket with arrowhead in K ⬘ ...dorsal midbrain (arrowheads in M), hindbrain ... See full document

11

Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development

Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development

... embryonic ventral midbrain In the ventral spinal cord, distinct progenitor domains have been identified based on different expression pat- terns of homeodomain transcription factors, such as ... See full document

17

Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons

Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons

... the ventral midbrain (VM) require for their development sonic hedgehog (Shh), as a ventralizing signal (Hynes et ...the midbrain-hindbrain border and its position is controlled by two ... See full document

11

Building and maintaining the epithelium of the lung

Building and maintaining the epithelium of the lung

... Even though basal cells represent the progenitor cell of pseu- dostratified airways with the greatest potential for clonal expan- sion and differentiation, luminal progenitor cells account for the majority of ... See full document

8

Sp8 controls the anteroposterior patterning at the
midbrain hindbrain border

Sp8 controls the anteroposterior patterning at the midbrain hindbrain border

... In order to elucidate whether the observed early perturbation of Otx2 and Gbx2 expression is accompanied by a change in cell fate in the rostral hindbrain, we used ephrin A5 and the homeobox gene Pitx3 as markers ... See full document

9

Gastric cancer and Hedgehog signaling pathway: emerging new
paradigms

Gastric cancer and Hedgehog signaling pathway: emerging new paradigms

... further Hedgehog inhibitors apparently acting downstream of Smoothened: HPI-1, HP-2, and HP-3 are thought to inhibit signaling by targeting a posttranslational modification of GLI or interaction between GLI ... See full document

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