[PDF] Top 20 Regulation of primordial germ cell development in the mouse

... ABSTRACT Primordial germ cells (PGCs) are the founders of the ...embryonic development and migrate to the gonadal ridges, where they differentiate into oogonia/oocytes in the ovary, and ... See full document

... stage mouse embryo reveals that the developmental fate of the cells is determined by their position in the germ ...to primordial germ cells (PGCs) and other types of somatic cells when they ... See full document

... female germ cells, together with expression of Cyp26b1 in the testis, suggested a mechanism for meiosis regulation in the developing gonads: RA was present in the fetal ovary to induce Stra8 (and initiate ... See full document

... are germ line-committed cells under certain in vivo and in vitro conditions, they can actually transform into embryonal carcinoma (EC) and embryonal germ (EG) stem cell lines (De Felici et ... See full document

... migrating germ cells, only a few genes have been identified as key ...Following germ cell specification, Nanog, Kit, Tial1, Nanos3 and Dnd1 are known to be highly transcribed in migrating PGCs (Beck ... See full document

... for germ cell development ...to mouse NSD1 and can associate with chroma- tin independently of ongoing transcription [3] (see below, and ... See full document

... enable cell type-specific expression in mammalian systems, generating an inducible system (mammalian TaDa or MaTaDa) to identify genome-wide protein/DNA interactions in 100 to 1000 times fewer cells than ... See full document

... the mouse is an A/T-rich ~230-bp- long monomer, which can be repeated many times, lead- ing to regions of up to several megabases in ...interphase mouse nucleus, pericentric constitutive het- erochromatin ... See full document

... where germ plasm and its maternal components are localized (Owens et ...with germ plasm components, and is thus considered a maternal PGC transcript (Table ...possible regulation by sox7 in Xenopus ... See full document

... of cell types, Akt is pivotal in the regulation of Bad (Bcl-2-antagonist of cell death), a BH3 only pro-apoptotic member of Bcl-2 ...other cell types, depends on the balance between members of ... See full document

... ABSTRACT Mouse primordial germ cells (PGCs) migrate from the base of the allantois to the genital ...Growth regulation of mouse PGCs has been studied by culturing them on feeder ... See full document

... During oogenesis, hundreds of maternal RNAs are selectively localized to the animal or vegetal pole, including determinants of somatic and germline fates. Although microarray analysis has identified localized ... See full document

... of germ line chimera (Stevens, ...normal development up to the expanded blastocyst stage, but after implantation they are absorbed, since their genomes are incorrectly imprinted (Kono et ...the germ ... See full document

... in mouse germ cells (Pepling and Spradling, ...E10.5 germ cells that develop into cysts will form clones of a size (number of cells) that is a power of two due to mitotic synchrony, whereas the clone ... See full document

... Application of genome editing technology in birds The chicken genome sequencing project was completed in 2004, and chicken genomic sequences have been available to the public since that time [119]. Subsequently, the gen- ... See full document

... ABSTRACT Primordial germ cells (PGCs) are the stem cell precursors of the germ ...(dpc) mouse embryos constitutively express the three subunits ( α , β and γ ) of the IL- 2 receptor ... See full document

... the germ cell population within the gonads, or if they are misallocated in other tissues to die by apoptosis, or if they have some other developmental ... See full document

... 1. Germ cell factors are restricted dorsally and on the left during ...(A) Primordial germ cells can be specified by either inherited mechanisms or inductive ...of germ cell ... See full document

... the germ plasm in most PGCs of uninjected ...contained germ plasm in the cortex at stage 12, compared with only ...of germ plasm in these PGCs was very similar to that in DEADSouth-knockdown PGCs ... See full document

... AID (activation-induced deaminase) and APOBECs (apolipoprotein B mRNA editing enzyme, catalytic polypeptides) are a group of cytidine deaminases in vertebrates that can introduce mutations in DNA and RNA by deaminating ... See full document