[PDF] Top 20 Renal cell–expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis
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Renal cell–expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis
... is essential for the development of glomerulonephritis, an immune-mediated disorder that is a major cause of renal failure ...However, TNF has proinflammatory and immunosuppressive ... See full document
12
Signal transduction pathways activated by the IL 1 receptor family: ancient signaling machinery in mammals, insects, and plants
... every cell in the body. On activation by IL-1, cells display an inflamed phenotype in that a large number of genes become expressed and most of these code for proteins that participate directly in ... See full document
8
Adenovirus RIDαβ Complex Inhibits Lipopolysaccharide Signaling without Altering TLR4 Cell Surface Expression
... are expressed (for recent reviews, see references 27, 34, 48, and ...by TNF- ␣ in murine cells by unknown mechanisms (28, 32), and it inter- acts with four unrelated cellular proteins, as shown by yeast ... See full document
9
Focus on the role of substance P in chronic urticaria
... In the authors’ opinion, the absence of increased serum SP levels in the majority of CSU patients appeared to deny an essential role of SP as a histamine-releasing factor in CSU in general, without however ... See full document
6
A pro inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor associated periodic syndrome (TRAPS)
... Ten microlitres of cellular lysates were loaded into a 384-well plate and serially diluted 5 times with 1 × SDS buffer. Sam- ples were spotted onto nitrocellulose-coated glass slides (Grace Bio-labs) with a ... See full document
15
Application of computational approaches to study signalling networks of nuclear and Tyrosine kinase receptors
... We further developed an integrated knowledge database, denominated NR-RTK database dedicated to human RTKs and NRs and their vertebrate orthologs and their interactions. These interactions were inferred using compu- ... See full document
9
Estrogen affects cell growth and IGF-1 receptor expression in renal cell carcinoma
... concluded that obesity is related to favorable cancer-specific postoperative survival in RCC patients. The obesity paradox suggests a complicated role and mechanisms by which obesity is involved in RCC ... See full document
6
RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti TNFα or anti IL 1 therapies
... Such divergence between clinical versus structural predictors of anti-inflammatory efficacy has also been reported following administration of TNFα blockers to mice with established CIA [46] or following overexpression ... See full document
15
Interleukin 2 receptor (Tac antigen) expressed on adult T cell leukemia cells
... (IL-2) receptor and the proliferative response to exogenous IL-2 of peripheral blood leukemic cells from patients with adult T cell leukemia (ATL) in order to see whether IL-2 ... See full document
9
TREM-1; is It a Pivotal Target for Cardiovascular Diseases?
... TREM-1 is an important inflammatory role player as orchestrator and player. It achieves its functions by interacting with PRRs and their putative DAMPS and PAMPS. We believed in CVD, PGLYRP-1 alone or ... See full document
19
Taubitz, Anela (2012): TNF-Rezeptor 1- und 2-spezifische Entzündungsreaktionen im Glomerulus. Dissertation, LMU München: Medizinische Fakultät
... To identify TNF-receptor 1 Tnfr1- and 2 Tnfr2-mediated inflammatory pathways in glomeruli expression and function of both TNF receptors were investigated in murine kidneys, in isolated g[r] ... See full document
231
Chronic epithelial kidney injury molecule 1 expression causes murine kidney fibrosis
... (rat, 1:100, cat. no. 6640; Abcam); SMA (mouse FITC coupled, 1:200, ...(lectin, 1:500, cat. no. L-1030; Vector Laboratories); Ki67 (rabbit monoclonal, 1:1000, ...monoclonal, 1:500 ... See full document
14
MicroRNA-647 promotes the therapeutic effectiveness of argon–helium cryoablation and inhibits cell proliferation through targeting TRAF2 via the NF-κB signaling pathway in non-small cell lung cancer
... highly expressed in NSCLC tumors that have been subjected to argon–helium cryoablation treatment, in contrast to those that underwent other ...suppresses cell viability and proliferation of NSCLC cells by ... See full document
8
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth : the role of sphingosine 1-phosphate receptor-4
... whole cell lysates were western blotted with anti-HA, anti-c-Src, anti-Y416 phosphorylated c-Src, and anti-actin ...HA-S1P 2 -transfected and vector-transfected ... See full document
51
Activators of peroxisome proliferator activated receptor gamma have depot specific effects on human preadipocyte differentiation
... Similar receptor levels were de- tected in immunoblots of freshly isolated preadipocytes and mature adipocytes in the same individuals using an antibody that recognizes both PPAR g 1 and - g 2 ... See full document
6
OX40 signaling directly triggers the antitumor effects of NKT cells
... within 2 hours, a mechanism more similar to NK ...NKT cell stimulant α-galactosyl- ceramide (α-GalCer), a marine sponge– derived glycosphingolipid that prevents metastasis of intravenously injected B16 ... See full document
5
TNF Super Family Members OPG, RANKL, RANK and Osteoporosis: a link
... are expressed by osteoblasts and stromal cells or other ...other cell types involved in immune responses, but they also regulate osteoblast ...the development of other tissues (at least in mice) and ... See full document
23
Heterozygous p.S811F RET gene mutation associated with renal agenesis, oligomeganephronia and total colonic aganglionosis: a case report
... non-familial renal dysplasia ...accompany development of OMN ...ney development [2, 3]. PAX2, encodes paired box gene 2, is a transcription factors expressed in nephric duct and ... See full document
5
Anti-TNF-alpha antibody attenuates subarachnoid hemorrhage-induced apoptosis in the hypothalamus by inhibiting the activation of Erk
... Rats under different treatments were killed 48 h after SAH. The hypothalamus was dissected from each rat and homog- enized in RadioImmunoPrecipitation Assay buffer consisting of 10 mM Tris pH 8.0, 150 mM NaCl, 1% ... See full document
12
Anticytokine Therapy: The Newer Horizons Revisited
... membranous-bound TNF-receptor (mTNF-R). There are type I TNF-R (55 kDa molecular weight) and type II TNF-R (75 kDa molecular weight) and differ with each other in their intracellular domain, ... See full document
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