[PDF] Top 20 The Reovirus σ1s Protein Is a Determinant of Hematogenous but Not Neural Virus Dissemination in Mice
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The Reovirus σ1s Protein Is a Determinant of Hematogenous but Not Neural Virus Dissemination in Mice
... Nonstructural protein 1s is a critical determinant of hematogenous dissemination by type 1 reoviruses, which reach the central nervous system (CNS) by a strictly blood-borne ...that ... See full document
10
Nonstructural Protein σ1s Is Required for Optimal Reovirus Protein Expression
... ABSTRACT Reovirus nonstructural protein 1s is required for the establishment of viremia and hematogenous viral ...the reovirus replication cycle is not ...efficient reovirus ... See full document
17
Nonstructural Protein σ1s Is a Determinant of Reovirus Virulence and Influences the Kinetics and Severity of Apoptosis Induction in the Heart and Central Nervous System
... neonatal mice with reovirus has provided important new insights into the mechanisms of viral entry, spread, tissue tropism, and disease pathogenesis in the infected ...31). Reovirus-induced apoptosis ... See full document
11
Mammalian Reovirus Nonstructural Protein μNS Forms Large Inclusions and Colocalizes with Reovirus Microtubule-Associated Protein μ2 in Transfected Cells
... cells. Reovirus particles, proteins, and RNA are then recruited to the sites of replication and particle ...of reovirus proteins and RNA, organize the dou- ble-stranded RNA synthesis or particle assembly ... See full document
13
The Nuclear Shuttle Protein of Tomato Leaf Curl New Delhi Virus Is a Pathogenicity Determinant
... symptom determinant, and the expression of this protein induces disease-like symptoms (2, 6, 7, 15, 17, ...curl virus and Tomato yellow leaf curl virus, the C4 protein is involved in ... See full document
6
Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B
... and/or protein-protein interactions mediated by the aromatic residues in NS4B amphipathic ␣ -helix 42–66 are required for the for- mation of a functional HCV replication ... See full document
12
Canine Distemper Virus Uses both the Anterograde and the Hematogenous Pathway for Neuroinvasion
... Measles virus holds an intermediate position, as it causes several distinct but relatively rare CNS ...acidic protein polyclonal antiserum or the 530/615 NeuroTrace Nissl stain, ... See full document
11
Control of protein synthesis by the reovirus S4 gene
... after virus binding or b) intra cellular effects on a 1 or <rlS proteins, or c) SI transcripts on synthetic ...The virus binds to a membrane protein and induces the inhibition of cellular DNA ... See full document
311
NKp46 Recognizes the Sigma1 Protein of Reovirus: Implications for Reovirus-Based Cancer Therapy
... by reovirus. (A) Vero cells were incubated with reovirus for 14 h and stained with anti-sigma1 antibody (open gray ...of reovirus was similar and is not ...of reovirus was similar and is not ... See full document
15
JC Virus Quasispecies Analysis Reveals a Complex Viral Population Underlying Progressive Multifocal Leukoencephalopathy and Supports Viral Dissemination via the Hematogenous Route
... JC virus generally harbors reorganized noncoding control region (NCCR) DNA interspersed on the viral genome between early and late coding ...JC virus highly resembled the archetype virus, and urine ... See full document
8
Strain-specific neutralizing determinant in the transmembrane protein of simian immunodeficiency virus.
... This strain-specific neutralizing determinant is located within a variable region of SIVmac and human immunodeficiency virus type 2 HIV-2 which includes conserved, clustered sites for N-[r] ... See full document
9
Functional Domains of Reovirus Protein µ2 that Determine the Interferon Response and Reovirus Replication.
... [r] ... See full document
144
Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation.
... Infectivity without antigen had been observed in the brains of rats 14 days after inoculation in the footpad; it is possible that infectious virus detected in the brain at that time was [r] ... See full document
10
Proteolytic digestion of reovirus in the intestinal lumens of neonatal mice.
... Thus, the early events of viral entry into the gastrointestinal tract can be summarized as a virusISVP-virus cycle in which the conversion of inoculated virus to ISVPs occurs in the lume[r] ... See full document
6
Protein architecture of avian reovirus S1133 and identification of the cell attachment protein.
... tural protein and therefore designated it m ...a protein of 76 kDa (which was not precipitated by polyclonal antireovirus antisera) in extracts of infected Vero ...neutralize virus infectivity and ... See full document
6
An Innate Immunity Regulating Virulence Determinant Is Uniquely Encoded within the Andes Virus Nucleocapsid Protein
... GnGc protein inhibits IFN-  induction resulting from the infec- tion of cells with Sendai virus (SeV) and instead found only a ~40% reduction in SeV-induced responses following cotransfec- tion of N and ... See full document
10
Apoptosis Induction Influences Reovirus Replication and Virulence in Newborn Mice
... of reovirus to induce apoptosis enhances viral infectivity and replication in the brain or whether the enhanced infectivity and replication in the brain leads to enhanced apoptosis and ...AD virus in brains ... See full document
10
Minute Virus of Mice Small Nonstructural Protein NS2 Interacts and Colocalizes with the Smn Protein
... 30 h postrelease from a highly synchronized MVM infection (12). Consistent with the results obtained in vitro, NS2 was FIG. 1. SMN and NS2 interact in vitro. (A) Western blot analysis of recombinant GST-tagged NS2 ... See full document
6
Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation
... The central hypothesis for LMP1 as an oncogenic signaling protein is that it is consistently expressed and detected in NPC tumors (10, 13). Several lines of evidence are consistent with the alternative hypothesis ... See full document
11
ACUTE HEMATOGENOUS OSTEOMYELITIS
... These principles are emphasized by a study of the charts (Table I) of all patients admitted to the Hospital for Sick Children with a diagnosis of osteomyelitis between January, 1956, and[r] ... See full document
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