Top PDF Case Report Multiple bilateral Warthin’s tumors of the parotid glands with pleomorphic adenoma: a case report

Case Report Multiple bilateral Warthin’s tumors of the parotid glands with pleomorphic adenoma: a case report

Case Report Multiple bilateral Warthin’s tumors of the parotid glands with pleomorphic adenoma: a case report

the cutting surface was gray and white. Pa- thology observation: dominant epithelial com- ponents intermingled with chondroid, myxoid and fibrous stroma. The structure was pleomor- phic showing the glandular epithelium and myo- epithelial epithelium. Two kinds of epithelium formed a double tubular structure, myoepithe- lial cells distributed in the myxoid regions. The tumor infiltrated local capsule. Histological diagnosis: pleomorphic tumor (Figure 2). Figure 1. Enhanced CT scan of the parotid gland. A. Two high density lesions were seen in the left parotid gland. Mild Homogeneous enhancement was seen in both tumors. B. The posterior one was 22 mm in diameter. C. The anterior one was 15 mm in diameter.
Show more

6 Read more

Carcinosarcoma of the parotid gland with abdominal metastasis: a case report and review of literature

Carcinosarcoma of the parotid gland with abdominal metastasis: a case report and review of literature

Carcinosarcoma, also called true malignant mixed tumor, is an aggressive malignant neoplasm of the saliv- ary gland. It is an extremely rare malignancy, comprising 0.04 to 0.16% of all salivary gland tumors and 0.4% of all malignant salivary gland neoplasms. The mean age at presentation is in the sixth to seventh decade of life, but can range from 14 to 87 years [1–3]. Although de novo carcinosarcomas can occur in the salivary gland, many patients have a history of long standing or recurrent pleomorphic adenomas, a condition described as carci- nosarcoma ex pleomorphic adenoma [4–6]. Most of these lesions arise in the major salivary glands, with two thirds in the parotid glands [2]. Patients typically present with a rapidly growing mass.
Show more

6 Read more

Bilateral granulosa cell tumors: a novel malignant manifestation of multiple endocrine neoplasia 1 syndrome found in a patient with a rare menin in-frame deletion

Bilateral granulosa cell tumors: a novel malignant manifestation of multiple endocrine neoplasia 1 syndrome found in a patient with a rare menin in-frame deletion

Introduction: Multiple endocrine neoplasia 1 (MEN1) is a cancer syndrome resulting from mutations of the MEN1 gene. The syndrome is characterized by neoplasia of the parathyroid and pituitary glands, and malignant tumors of the endocrine pancreas. Other manifestations include benign lipomas, angiofibromas, and carcinoid tumors commonly originating in the colon, thymus, and lung. This is the first report of MEN1 syndrome manifesting as bilateral granulosa cell ovarian tumors, and which is associated with a rare intronic mutation of the MEN1 gene. Case report: A 41-year-old woman presented with abdominal pain, increasing abdominal girth, and dysmenorrhea. Ultrasound demonstrated enlarged ovaries and uterine fibroids. After an exploratory laparotomy, she subsequently underwent bilateral salpingo–oophorectomy with hysterectomy where the pathology revealed bilateral cystic granulosa cell tumors of the ovaries. Additional workup including computed tomography imaging discovered a thymic mass, which the pathology showed was malignant, along with a pancreatic mass suspicious for a neuroen- docrine tumor. Hyperparathyroidism was also discovered and was found to be secondary to a parathyroid adenoma. Genetic testing revealed an exceedingly rare mutation in the MEN1 gene (c.654 + 1 G.A).
Show more

5 Read more

A Rare Case of Synchronous Bilateral Pleomorphic Adenoma of the Parotid Gland

A Rare Case of Synchronous Bilateral Pleomorphic Adenoma of the Parotid Gland

Multiple parotid gland tumors are unusual. Warthin’s tumor is the most represented neoplasm in this condition. We present a case of bilateral synchronous pleomorphic adenoma affecting the pa- rotid glands in a 28-year-old woman. Clinically, the lesions were similar to solitary pleomorphic adenoma. Both lesions were diagnosed by fine-needle aspiration cytology. A total parotidectomy for left tumor and surgical enucleation for the right tumor, respectively, were performed with no facial nerves injury. A review of the pertinent literature is included.
Show more

6 Read more

Juvenile pleomorphic adenoma of the cheek: a case report and review of literature

Juvenile pleomorphic adenoma of the cheek: a case report and review of literature

Pleomorphic adenoma, also called benign mixed tumor, is the most common tumor of the salivary glands. About 90% of these tumors occur in the parotid gland and 10% in the minor salivary glands. The most common sites of pleomorphic adenoma of the minor salivary glands are the palates followed by lips and cheeks. Other rare sites include the throat, floor of the mouth, tongue, tonsil, pharynx, retromolar area and nasal cavity. In children, intraoral pleomorphic adenomas of the cheek are extremely rare with only three cases reported to date. Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in a 17-year-old girl. The mass was removed by wide local excision with adequate margins, and after a follow-up period of three years there were no recurrences. To conclude, pleomorphic adenoma should be considered in the differential diagnosis of cheek masses in youngsters. Wide local excision is to be recommended as the treatment of choice. A close follow-up is necessary postoperatively.
Show more

5 Read more

High Grade Mucoepidermoid Carcinoma  Ex Pleomorphic Adenoma of the Parotid Gland:  Case Report and Review of Literature

High Grade Mucoepidermoid Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: Case Report and Review of Literature

Multiple studies on FNA specimens from salivary glands have confirmed high accuracy in distinguishing benign from malignant lesions. CxPA of the salivary gland, however, poses diagnostic difficulty on FNA [6], with some studies reporting sensitivities less than 30%; this has important clinical implications and may misdi- rect initial management towards incorrect treatment [3]. Similarly, only 30% (two high grade, one low grade) of the reported cases had cytologic features consistent with MECxPA, such as mucous-containing and squamous malignant cells in a chondromyxoid background with myoepithelial cells. High grade MEC was misdiagnosed, since the high grade component, although always present, was too similar to other metastatic or primary high grade malignancies such as adenocarcinoma not otherwise specified or SCCA [5]. Low grade MEC was misdiag-
Show more

5 Read more

Case Report Giant pleomorphic adenoma of the parotid gland with a history more than forty years without malignant transformation

Case Report Giant pleomorphic adenoma of the parotid gland with a history more than forty years without malignant transformation

Abstract: Pleomorphic adenoma (PA) is the most common type of all salivary gland tumors. Although PAs are benign in pathology, they are malignant in biological behavior sometimes. The tumor could transform to malignancy as malignant pleomorphic adenoma (MPA), if the preexisting remains for long time or after multiple recurrent. Cases of giant pleomorphic adenomas (GPA) are rare, according to previous medical literatures, the majority of which were involving in the parotid gland. We presented a 73-year old woman with a giant pleomorphic adenoma in left parotid gland who had kept the mass for more than forty years and was successfully treated with surgery without any facial nerve injury.
Show more

5 Read more

Case Report Primary pleomorphic adenoma of the lung with positive staining of TTF-1: a case report and review of literature

Case Report Primary pleomorphic adenoma of the lung with positive staining of TTF-1: a case report and review of literature

Based on clinical information, histological fea- tures, and the immunohistochemical staining profile described above, the tumor was diag- nosed as a primary pleomorphic adenoma of the lung. Pleomorphic adenoma is a common tumor in the salivary glands of the head and neck, especially the parotid gland. Pleomorphic adenoma arising in regions other than the head and neck are very rare. Few reports have docu- mented its presence in other regions, such as lung and lower eyelid [11, 13]. To date, less than 20 cases of pleomorphic adenoma of the lung have been reported in the literature (Ta- ble 1) [1-12]. Previous reports and ours have summarized the features of pleomorphic ade- noma of the lung. This tumor often occurs in middle and old age patients (≥40 years old). The occurrence of this tumor does not differ by gender. Macroscopically, these tumors are ty- pically well-circumscribed, and ranging from 1.5 to 16 cm in size. The cut surface can ap- pear grayish white, soft, rubbery, and myxoid. Figure 1. The image of computed tomography exami-
Show more

6 Read more

Development of Aseptic Renal Abscess in a Patient with Non Small Cell Lung Cancer with ALK Translocation during Crizotinib Treatment

Development of Aseptic Renal Abscess in a Patient with Non Small Cell Lung Cancer with ALK Translocation during Crizotinib Treatment

Background: Crizotinib is a tyrosine kinase inhibitor of ALK, MET and ROS1. In a safety database trial, it was suggested an association of Crizotinib with the development of renal cyst in patients with non-small-cell lung cancer (NSCLC). Aim: To report an uncommon side effect of Crizotinib in a patient with NSLC. Case Presentation: We report the case of a 68-year-old woman with NSCLC who developed bilateral progressive aseptic renal abscesses during Crizotinib treatment. Conclusion: Further studies may be necessary to determinate the risk of renal cyst development and the man- agement of these complications.
Show more

5 Read more

Case Report Multifocal canalicular adenoma of the minor labial salivary glands

Case Report Multifocal canalicular adenoma of the minor labial salivary glands

CA is included in the group of salivary gland adenomas by the WHO, and its most important differential diagnoses are ACC and basal cell adenoma (BCA). In addition, its multifocal and cribriform patterns should not be interpreted as evidence of malignancy. BCA is a rare benign epithelial neoplasia characterised by a predom- inance of basaloid cells, without the chondro- myxoid component of pleomorphic adenomas [5]. Although the major salivary glands repre- sent its most frequent site (parotid: 75%, sub- mandibular gland: 5%), some reports suggest that when rarely seen in the minor salivary glands, it has a predilection for the upper lip [5, 15, 25]. Immunohistochemistry has now estab- lished that CA develops from luminal ductal cells whereas BCA is originated in the salivary gland parenchyma [6]. BCA is positive for p63, α-SMA, cytokeratins and EMA, supporting its ductal and myoepithelial differentiation, while CA shows pure luminal ductal cell differentia-
Show more

6 Read more

Right thyroid hemiagenesis with adenoma and hyperplasia of parathyroid glands -case report

Right thyroid hemiagenesis with adenoma and hyperplasia of parathyroid glands -case report

A 66-year-old woman was diagnosed with primary hyperparathyroidism, Hashimoto thyroiditis, and tumor in the left thyroid lobe in July 2009. There was no family history of thyroid and parathyroid disease. The para- thyroid hormone (PTH) was elevated (136.2 pg/ml vs. normal value of 15–65 pg/ml) as well as calcium (Ca) level (2.73 mmol/L vs.normal value of 2.15-2.55 mmol/L). Also, thyroglobulin antibodes (TG-Ab), thyroid perox- idase antibodies (TPO-Ab) and thyroid stimulating hor- mone (TSH) (17.58 microU/ml vs. normal value of 0.27-4.2) were elevated, but L-thyroxine (T4) level was decreased (64.89 nmol/L vs. normal of 66–181 nmol/L). The patient was treated by L-thyroxine50 μg daily. The patient did not have nephrolithiasis or osteoporosis. Ultrasound of the neck verified absence of right thyroid lobe with heterogeneous structure size of 23x45 mm in the left lobe and enlarged lower left parathyroid gland size of 8x6 mm (Figure 1). Fine needle aspiration biopsy (FNAb) was not performed and the decision for the oper- ation has been made only based on clinical and ultrasono- graphic findings. Technetium 99mTc-methoxyisobutyl isonitrile (MIBI) scintigraphy of parathyroid glands ini- tially showed no pathological accumulation and only the left thyroid lobe could be visualized. (Figure 2). Tc99 was
Show more

6 Read more

Basal Cell Adenoma of the Parotid Gland: A Case Report and Review of the Literature

Basal Cell Adenoma of the Parotid Gland: A Case Report and Review of the Literature

2.Ogawa I, Nikai H, Takata T, Miyauchi M, Ito H, Ijuhin N. The cellular composition of basal cell adenoma of parotid gland: An Immunohistochemical analysis. Oral Surg Oral Med Oral Pathol1990;70(5):619-26. 3.González-García R1, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C. Basal cell adenoma of the pa- rotid gland. Case report and review of the literature. Med Oral Patol Oral Cir Bucal 2006;11(2):E206-9 4.Chakravarthi S, Rao V.T, Prasad L.K, Kalyan, Kat- timani V.S. Basal Cell Adenoma – A Rare Presentation of Parotid Swelling – A Case Report and Review of The Literature. Jr.of Orofac. Scie. 2009;1(2):13-16. 5.Chawla AJ, Tan TY, Tan GJ. Basal cell adenoma of parotid gland: CT scan features Eur J Radiol 2006;58(2):260-5.
Show more

5 Read more

Giant parotid duct Sialolith   A case report

Giant parotid duct Sialolith A case report

“Descriptive research involves collecting data in order to test hypothesis or to answer question concerning the current status of the subject of the study”. It involves collecting data to test hypothesis or to answer questions about people’s opinions on some topic or issue. A descriptive study determines and reports the way things are. Sometimes it is named as, non- experimental research because it is concerned with the assessment of attitudes, opinions, demographic, information, conditions, and procedures. Descriptive data rare usually collected through a questionnaire survey, interview or observation. The descriptive research has to control over ‘what is’ and can only measure what already exist. 15 ”Some types of descriptive research methods include surveys, analyses, case studies, observation and review of published reports or results. Questionnaire was used for the purpose of collecting data regarding Montessori schooling. A questionnaire was prepared which covered the aspects of the problem under study i.e. the impact of poorly trained teachers for Montessori schooling. To avoid ambiguity, the questions were constructed in simple and clear words. The teachers were required to tick mark the appropriate one. It was finalized after a detailed discussion, consideration and re-arrangement and after checking its relevancy to the topic.
Show more

5 Read more

Histomorphological patterns of  salivary gland tumors

Histomorphological patterns of salivary gland tumors

The myoepithelial cells usually do not demonstrate glandular formation, but occasionally some of the cells which are located around the ductal cells exhibit glandular formations. The myoepithelial cells exhibit various cell morphology like epithelioid, spindle, plasmacytoid and clear cell types. Hence immunohistochemistry analysis is necessary for more accurate diagnosis of tumors that show myoepithelial differentiation 136 .

150 Read more

A Rare Case Report of Parotid Cavernous Hemangioma in an Adult

A Rare Case Report of Parotid Cavernous Hemangioma in an Adult

The etiology of hemangioma is still elusive. Controversies surround all explanation from gene mutation to developmental factors for etiopathogenesis of hemangioma. Few evidences demonstrate that dendritic cells play an important role in the formation of hemangioma through some cytokine, such as vascular endothelial growth factor while some experts concluded that hemangioma originates from embryo of angioblasts [4]. Recently, the expression of cyclooxygenase 2 (COX2) protein on endothelial cells of several vascular spaces of cavernous hemangioma have been found but has little proof with the relationship of vascular tumors [8].
Show more

5 Read more

Rectal carcinoma and multiple gastrointestinal stromal tumors (GIST) of the small intestine in a patient with neurofibromatosis type 1: a case report

Rectal carcinoma and multiple gastrointestinal stromal tumors (GIST) of the small intestine in a patient with neurofibromatosis type 1: a case report

Background: Neurofibromatosis type 1 (NF1) is an autosomally dominant inherited disorder characterized by multiple pigmented skin spots ( café-au-lait spots) and neurofibroma. NF1 is associated with a wide variety of benign or malignant tumors. We report a NF1 patient who received surgical treatment for rectal carcinoma and multifocal small intestinal gastrointestinal stromal tumors (GISTs).

5 Read more

Case Report Multiple genital tract tumors and mucinous adenocarcinoma of colon in a woman with Peutz-Jeghers syndrome: a case report and review of literatures

Case Report Multiple genital tract tumors and mucinous adenocarcinoma of colon in a woman with Peutz-Jeghers syndrome: a case report and review of literatures

The exact mechanism of carcinogenesis in PJS remains to be established. Two possible modes of cancer development have been proposed in PJS: de novo carcinogenesis and a hamartoma- adenoma-carcinoma sequence [2]. In this case, P-J polyps had hyperplastic glands and the epi- thelial misplacement was florid and extended into the serosa. Chains or irregular cell clusters floating freely in mucinous lakes. Thus, the car- cinomas may occur in contiguity with p-j polyps. There are some tubular adenomas with dyspla- sia in the colon, so the colon cancer might have developed through hamartoma-adenoma-car- cinoma sequence.
Show more

6 Read more

www.ijcep.com /IJCEP1012011 Case Report Invasive pleomorphic lobular carcinoma, negative for ER, PR and Her/2neu - a case report

www.ijcep.com /IJCEP1012011 Case Report Invasive pleomorphic lobular carcinoma, negative for ER, PR and Her/2neu - a case report

Invasive pleomorphic lobular carcinoma (IPLC) is a rare and aggressive variant of invasive lobu- lar carcinoma (ILC). Though its morphological features have been well described by different authors [1 -6], there is conflicting data in the literature concerning the presence of estrogen receptor, progesterone receptor and Her2/neu receptor. Both invasive and in situ variants of pleomorphic lobular carcinoma are known to be positive for hormone receptors, to over express HER2/neu and to lack E-cadherin [1-3].

6 Read more

An unusual case of spleen metastasis from carcinoma ex pleomorphic adenoma of the parotid gland

An unusual case of spleen metastasis from carcinoma ex pleomorphic adenoma of the parotid gland

In the evaluation of salivary gland tumors, the use of 18- fluoro-2-deoxy-D-glucose positron emission tomography ( 18 F-FDG PET) remains a matter of debate. Kim et al. il- lustrated an association between high FDG uptake and Glut-1 overexpression in CXPA, and they noticed that it could offer a basis for the clinical application of 18 F-FDG PET and Glut-1 for differential diagnosis between CXPA and PA [15]. Otsuka et al. showed that FDG PET had a significant impact on the management of patients with salivary malignant tumors in both the initial staging and restaging [16]. In our case, despite the proper therapeutic management, the patient relapsed 1 year later. Moreover,
Show more

5 Read more

Case Report Occult oncocytic papillary thyroid carcinoma with lymphoid stroma (Warthin-like tumor): report of a case with concomitant mutations of BRAF V600E and V600K

Case Report Occult oncocytic papillary thyroid carcinoma with lymphoid stroma (Warthin-like tumor): report of a case with concomitant mutations of BRAF V600E and V600K

Papillary carcinoma (PC) is the most common histotype of thyroid carcinoma, and often has a favorable prognosis than other carcinoma types. Warthin-like papillary thyroid carcinoma (WLPTC) is an uncommon variant which has papillary architecture with prominent lympho- cytic stroma in their stalks, histologically resembling Warthin tumor of the salivary gland. The neoplastic cells lining the papillae have nuclear features of usual PC with oncocytic cytoplasm [1-12]. Recent studies demonstrat- ed that papillary carcinoma have frequently genetic alterations involving in BRAF mutation or RET arrangement which leads to activation of the MAPK signaling pathway. So far, the BRAF mutation detected in PTC has been the V599E or V600E in exon 15, only rarely has other point mutation of BRAF gene been found in PTC [13-16]. The presence of BRAF mutation in PTC is an early event and has been associ- ated with older age of patient, advanced tumor
Show more

6 Read more

Show all 10000 documents...

Related subjects