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[PDF] Top 20 Repurposing metformin for cancer treatment: current clinical studies

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Repurposing metformin for cancer treatment: current clinical studies

Repurposing metformin for cancer treatment: current clinical studies

... investigating metformin as a potential anti-cancer agent for cases of breast ...using metformin as an anti-cancer agent; Tables 1-3) are focused on evaluating metformin as a ... See full document

14

Drug repurposing for the treatment of glioblastoma multiforme

Drug repurposing for the treatment of glioblastoma multiforme

... proteogenomic studies have led to the identifica- tion of diverse molecular signatures and actionable sig- naling pathways in GBM, such as those targeting EGFR and PI3K [3, ...these clinical events are ... See full document

11

Understanding the benefit of metformin use in cancer treatment

Understanding the benefit of metformin use in cancer treatment

... epidemiologic, clinical and preclinical evi- dence supporting a potential anticancer effect of metfor- min has led to an explosion of interest in evaluating this agent in human ...a cancer therapy. In ... See full document

6

Metformin: A possible drug for treatment of endometrial cancer

Metformin: A possible drug for treatment of endometrial cancer

... of studies on antitumor effects of metformin require careful consideration of the administered concen- ...mM metformin is commonly used, whereas the upper limit of the dose per day in ... See full document

6

Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects

Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects

... the metformin effects CRC risk among ele- vated BMI patients with colorectal adenoma was studied in a phase IIa clinical trial on Southern California ...given metformin at a dose of 1000 mg over 3 ... See full document

23

Effects of metformin treatment on radiotherapy efficacy in patients with cancer and diabetes: a systematic review and meta-analysis

Effects of metformin treatment on radiotherapy efficacy in patients with cancer and diabetes: a systematic review and meta-analysis

... among studies in the comprehensive antitumor treatment strategy ...included studies did not provide details on whether patients continued treatment with adjuvant therapy after ...a ... See full document

10

The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors

The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors

... nutlin-3, studies on small molecular MDM2 inhibitors have developed ...[56]. Clinical trials of various small molecular MDM2 inhibitors are under ...way. Current studies suggest that for ... See full document

8

<p>The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances</p>

<p>The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances</p>

... Several clinical studies have been conducted to improve the therapeutic response when using ...treat cancer. One of the greatest clinical trials con- ducted to date is called ...of ... See full document

19

Clinical utility of trabectedin for the treatment of ovarian cancer: current evidence

Clinical utility of trabectedin for the treatment of ovarian cancer: current evidence

... 3. When considering the whole series in each study, the response rate ranges between 16.3% and 38.9%, although the relatively high patient heterogeneity likely represents a major limit for reliable comparisons. Indeed, ... See full document

12

/ISSN:1940-5901/IJCEM0054496

/ISSN:1940-5901/IJCEM0054496

... Abstract: Metformin, an insulin sensitizer, is a biguanide commonly used to treat type 2 diabetes ...of clinical studies on its anti-tumor effects have suggested that metformin not only ... See full document

7

Repurposing Dichloroacetate for the Treatment of  Multiple Myeloma

Repurposing Dichloroacetate for the Treatment of Multiple Myeloma

... of cancer cells to chemotherapy drugs [50]. In human colon cancer tissues, PDK3 levels are elevated and correlated with the HIF-1α level and strongly correlated with the severity of the cancer and ... See full document

237

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment

cancer treatment

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment cancer treatment

... several cancer types (adrenocortical carcinoma, melanoma, HNSCC and colon, 29 – 32 including an ongoing Phase I study in paediatric brain tumours, ...single treatment, while treatment for ... See full document

11

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes : the MET REMODEL trial

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes : the MET REMODEL trial

... of treatment with change in LVMI, LVM and treatment as fixed effects, and age, sex, and baseline values for LVMI/LMI, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), prescription ... See full document

9

Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells

Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells

... single treatment with isoliquiritigenin scarcely induced apoptosis in HT29 ...Combined treatment with suboptimal concentrations of isoliquiritigenin and TRAIL markedly induced apoptosis, ... See full document

7

Licofelone (Merckle)

Licofelone (Merckle)

... General pharmacological studies demonstrated that oral administration of licofelone (30, 100 or 300 mg/kg) did not affect the central nervous system. Licofelone (100 mg/kg id) had no notable effect on the ... See full document

7

Metformin or Oral Contraceptives for Adolescents With Polycystic Ovarian Syndrome: A Meta-analysis

Metformin or Oral Contraceptives for Adolescents With Polycystic Ovarian Syndrome: A Meta-analysis

... small studies limited to adolescents and as such the true effect may be substantially different from that estimated in this ...against metformin or OCP use when treating adolescents with PCOS and need to ... See full document

14

Gender Satisfaction among Type 2 Diabetes Patients: A Comparison between Intensive Diets, Lifestyle Intervention with Medication Controlled Management

Gender Satisfaction among Type 2 Diabetes Patients: A Comparison between Intensive Diets, Lifestyle Intervention with Medication Controlled Management

... with metformin n=617 patients (generic 1000 mg twice daily after gradually build-up dose over 2 weeks) and/or sulfonylurea (usually glimepiride 4 mg daily), n=139 patients or sitagliptin 100 mg daily which was ... See full document

13

Implications of the HDAC6-ERK1 feed forward loop in immunotherapy

Implications of the HDAC6-ERK1 feed forward loop in immunotherapy

... these clinical combinations must eventually be brought back to the bench to determine the mechanisms of synergy, which can offer information about alternative approaches for future clinical ... See full document

10

Natural History of Invasive Papillary Breast Carcinoma Followed for 10 Years: A Case Report and Literature Review

Natural History of Invasive Papillary Breast Carcinoma Followed for 10 Years: A Case Report and Literature Review

... Papillary breast carcinoma is a rare type of breast cancer, accounting for less than 1% of all breast cancer cases [3]. It has a favorable prognosis, which was evident in the present case [4]. Lymph node ... See full document

5

Clinical potential of bevacizumab in the treatment of metastatic and locally advanced cervical cancer: current evidence

Clinical potential of bevacizumab in the treatment of metastatic and locally advanced cervical cancer: current evidence

... Given the aberrant vasculature and hypoxic nature of cervical carcinoma, bevacizumab as well as other targeted agents have been investigated as means to manipulate the angiogenic milieu and limit the propagation of these ... See full document

9

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