[PDF] Top 20 Research Progress of Cardiac Myosin Binding Protein C in Dilated Cardiomyopathy and Other Cardiac Conditions
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Research Progress of Cardiac Myosin Binding Protein C in Dilated Cardiomyopathy and Other Cardiac Conditions
... hypertrophic cardiomyopathy. More and more mutation sites of cMyBP-C pa- thogenic genes have been found, and about 350 have been reported so far ...truncated protein models of which one expresses a ... See full document
10
Dilated cardiomyopathy in homozygous myosin binding protein C mutant mice
... the C-zone of the A-band, on either side of the M-band (11–13, ...the cardiac dys- function evident in mutant ...MyBP- C mice develop dilated cardiomyopathy, we suggest that M-band loss ... See full document
11
HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C
... MYBPC3 protein in NRVMs, despite similar experimental conditions ...pathological cardiac remodel- ing, as has been observed for other forms of cardiomyopathy and heart failure ... See full document
17
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β cardiac myosin
... Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease, with a prevalence of more than one in 500 individuals ...acquired dilated cardiomyopathy is a related ... See full document
7
Cardiac Myosin Binding Protein C: At the Heart of Hypertrophic Cardiomyopathy in Humans and Domestic Cats
... and myosin binding domains (Yang et al., 1998). The mutant protein was found to be stable, but was not incorporated efficiently into the ...mutant protein lead to decreased levels of normal ... See full document
7
Novel splice donor site mutation in the cardiac myosin binding protein C gene in familial hypertrophic cardiomyopathy Characterization Of cardiac transcript and protein
... for cardiac MyBP-C of four individual biopsies from the index patient was per- formed and the results compared with reference samples of ventricular tissue from patients with aortic stenosis, ischemic ... See full document
9
Genetics of inherited cardiocutaneous syndromes: a review
... 17q21. Cardiac myocytes are connected by complex intercellular contact sites called intercalated discs, which contain three different types of intercellular ... See full document
13
Mapping a cardiomyopathy locus to chromosome 3p22 p25
... The relative importance of this DCM locus is not yet known. Because mortality in idiopathic DCM is high (5-yr mortality 5 40–80%) (28) and penetrance is incomplete, DCM families suitable for linkage analysis are rare. ... See full document
6
Did Frédéric Chopin die from heart failure?
... Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following ...and/or other copyright ... See full document
11
Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy
... Dilated cardiomyopathy has been increasingly of concern in both domestic and commercial animals. The economic loss, food security threats and impact of loss and treatment costs make the condition important ... See full document
16
Variability of cardiovascular magnetic resonance (CMR) T1 mapping parameters in healthy volunteers during long-term follow-up
... All scans were performed on the same Philips 1.5 Tesla MRI scanner (Achieva) with a 32-element cardiac receiver coil and vector-ECG gating. Steady-state free-pre- cession cine sequences were applied in contiguous ... See full document
6
Myocardial contractility in the stress echo lab: from pathophysiological toy to clinical tool
... Additional file 2: Dilated Cardiomyopathy: The sarcomere At each cycle of heartbeat, the heart cell contracts (shortens) at systole and relaxes at diastole. Under stress, both the speed and the intensity of ... See full document
11
Risk Stratification for Sudden Cardiac Death In Patients With Non-ischemic Dilated Cardiomyopathy
... ischemic dilated cardiomyopathy (NIDCM) is a disorder of ...sudden cardiac death ...ischemic dilated cardiomyopathy ...sudden cardiac death from sustained ventricular ...sudden ... See full document
17
Original Article Association between collagen cross-linking and cardiac function and remodeling in rats with furazolidone-induced dilated cardiomyopathy
... sudden cardiac death (SCD) in nonisch- emic dilated cardiomyopathy ...stage C heart failure, moreover, CCL is positively corre- lated with insoluble stiff collagen and myocar- dial expression ... See full document
9
Presymptomatic diagnosis of Fabry’s disease: a case report
... severe cardiac dysfunction and their life expectancy is reduced by 20 and 15 years in males and females, respectively ...A cardiac variant, characterized by only – or mainly – cardiac involve- ment ... See full document
5
Spectrum of heart diseases in a new cardiac service in Nigeria: An echocardiographic study of 1441 subjects in Abeokuta
... found dilated cardiomyopathy as the commonest form of cardiomyopathy in Abeokuta similar to other ...peripartum cardiomyopathy (PPCM) is relatively uncommon compared to reports from the ... See full document
10
Differential regulation of two types of intracellular calcium release channels during end stage heart failure
... two cardiac intracellular calcium release channels were regulated in opposite directions in failing human ...human cardiac myocytes. The relative amounts of IP3 binding sites increased approximately ... See full document
8
Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations
... beta cardiac MHC mutations are also associated with sporadic disease, we screened this gene in seven individuals with sporadic hypertrophic ...beta cardiac MHC genes were identified in two probands with ... See full document
7
Inpatient detection of cardiac-inherited disease: the impact of improving family history taking
... adult cardiac referral centre directly, or via transfer, from their local ...by cardiac-inherited ...inpatient cardiac investigation, or had a FHx of cardiac-inherited disease, or those who ... See full document
6
Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies
... all other samples, including NF con- ...exacerbate cardiomyopathy, as evidenced by our study of a potentially nov- el csPLA-Tg mouse line in which severe cardiac dysfunction was ...HIV-associated ... See full document
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