[PDF] Top 20 Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis

Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis

... H van der Velden PA Reitsma PH Mutation in blood coagulation factor V associated with resistanceto activated protein C Nature 1994,369 64-67 11 HalbmayerWM,HaushoferA,SchonR,FischerM The[r] ... See full document

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A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis

... our local APC resistance lest After stratification of the normal- ized APC-SRs mto quartiles, we observed that 45% of the subjects m the lowest quartile (n-APC-SR <0 92) had high fact[r] ... See full document

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Incidence and risk factors of portomesenteric venous thrombosis after colorectal surgery for cancer in the elderly population

... portomesenteric venous thrombosis was ...plasminogen, protein C, protein S, homocysteine level, factor V Leiden mutation, and prothrombin G20210A ... See full document

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Identification of the same factor V gene mutation in 47 out of 50 thrombosis prone families with inherited resistance to activated protein C

... to activated protein C (APC) is the most prevalent inherited cause of venous ...APC resistance phenotype is associated with a single point mutation in the factor V gene, ... See full document

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Factor V levels and risk of venous thrombosis: The MEGA case-control study

... increased risk for ...the risk for VT in individuals without a clinical risk factor for VT, and that the link is obscured in patients in whom a provoked risk factor was ... See full document

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Acquired activated protein C resistance and thrombosis in multiple myeloma patients

... restrictive factors associated to development of ...thrombotic risk, particularly in combination with chemotherapy and APC- R could be an additional factor associated to the DVT ... See full document

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<p>Prevalence and Outcomes of Thrombophilia in Patients with Acute Pulmonary Embolism</p>

... The risk of pulmonary hypertension is high in our cohort ...by activated protein C (APC) resistance which is caused by mutation in factor V (factor V ... See full document

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High levels of factor XI and the risk of venous thrombosis

... Also, when we excluded subjects who had known genetic risk factors for thrombosis (e.g., protein C or S deficiency, antithrombin deficiency, the factor V Lei- den mutation, orthe prothro[r] ... See full document

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Preeclampsia and genetic risk factors for thrombosis: a case control study

... We found no differences m the prevalence of inherited nsk factors for venous thrombosis, mcluding factor V Leiden, prothrombm 20210A allele, and protem C, protem S, and antithrombin de[r] ... See full document

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Factor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis

... “activated protein C” (APC). As a result, Factor V Leiden would not be inactivated, remains activated in the prothrombinase complex and consequently, more thrombin will be ... See full document

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High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)

... From this, it follows that the relative risk associated with oral contraceptive use is the same for homozygous women äs for women with the other genotypes (under the reasonable assumptio[r] ... See full document

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Factor V Leiden

... 18 Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH High risk of thrombosis m patients homozygous for factor V Leiden 30 (activated protein C resistance) Blood 1995, 85 1504-8. 19 Ri[r] ... See full document

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Incidence and risk factors of early venous thrombosis associated with permanent pacemaker leads

... Established risk factors for venous thrombosis were as- sessed in detail for all ...of venous thrombosis, use of female hormones (oral contra- ceptives, hormone replacement ... See full document

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Severe hyperhomocysteinemia due to cystathionine β-synthase deficiency, and Factor V Leiden mutation in a patient with recurrent venous thrombosis

... severe thrombosis leading to am- putation of the leg ...vein thrombosis despite only mild elevation of the homocysteine level ...increase risk of vascular damage and ... See full document

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Causes of venous thrombosis

... genetic risk factors for venous thrombosis are deficiencies of the natural anticoagu- lants protein C, protein S and antithrombin (reviewed in [11, ...strong risk ... See full document

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Physiological anticoagulation Resistance to activated protein C and venous thromboembolism

... Genetic risk factors yet to be discovered Inherited APC resistance taken together with deficiencies of protein C, protein S and antithrombin may account for up to 60-70% of cases with fa[r] ... See full document

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Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

... The relevance of heterozygosity for hereditary protein C deficiency äs a risk factor for venous thrombosis has been disputed because heterozygotes without Symptoms have been identified a[r] ... See full document

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Lower extremity venous thrombosis in patients younger than 50 years of age

... and risk factors for venous thrombosis; data were entered and analyzed by SPSS Statistics (IBM Corporation, Somers, NY) software, version ...and risk factors for venous ... See full document

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A case report of a new pulmonary embolism occurring in a patient receiving continuous infusion of recombinant activated protein C

... human activated protein C (rhAPC) has been demonstrated to improve mortality in critically ill patients with septic shock ...This risk has led to the general practice of discontinuing the use ... See full document

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Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis

... of factor V Leiden ...of factor V Leiden carriers without thrombosis, could have distorted our ...developed thrombosis, they will have had more risk ... See full document

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