Figure 4.1.10.2: Cell viability and cell cycle kinetics following culture of the OCI-AML3 cell line with glasdegib (2.67µM, 5.34µM and 10.68µM; clinically achievable

(CaAl 2 Si 2 O 8 .4H 2 O), hydrated calcium silicate (Ca 1. 3) The decrease in the intensity of the peaks of the anhydrous minerals and increase in the intensity of the peaks

Arsenic trioxide inhibits the Hedgehog pathway which is aberrantly activated in acute promyelocytic leukemia. Defining a role for Sonic hedgehog

As Ezrin expression has been associated with increased migration of tumour cells (Zhou et al., 2010b), a reduction in its tyrosine phosphorylation, changes to its

AML cell lines HL60, U937 and THP-1 were treated with anti-TNF to investigate the effect of reduced TNF signalling on the levels of IκBα mRNA present within the

In 2008 there were 73 adult* patients with a new diagnosis of acute lymphoblastic leukaemia, acute myeloid leukaemia or chronic myeloid leukaemia in Northern Ireland (Table 4)..

Intensive consolidation chemotherapy (ICC) vs purged autologous bone marrow transplantation (ABMT) early in remission for treatment of childhood acute myeloid leukaemia

Acute leukaemia may be derived from the myeloid stem cells called acute myeloblastic leukaemia (AML), or from the lymphoid stem cells termed acute lymphoblastic

There is also evidence that ACTH signalling has a role in stem/progenitor cell regulation as well as cortex zonation and maintenance.. 1.6.1 The Hedgehog

AML, acute myeloid leukaemia; CLL, chronic lymphocytic leukaemia; CML, chronic myeloid leukaemia; CRC, colorectal cancer; EGFR, epidermal growth factor receptor; FLT3,

Inhibition of the FLT3 receptor in MV4-11 cells resulted in significantly decreased NOX4 67 kDa and NOX4D 28 kDa protein levels in whole cell lysates, significantly

8-oH-dG: 8-hydroxydeoxyguanosine; AML: Acute myeloid leukemia; Ara- c: Cytosine arabinoside; CKI: Compound kushen injection; GSH: Glutathione; HLL: Hyperleukocytic leukaemia;

Acute myeloid leukaemia of donor cell origin developing 5 years after allogeneic bone marrow transplantation for chronic myeloid leukaemia.. Bone

As soon as the symptoms and the patient’s clinical condition improves, treatment with ATRA will be resumed at 50% of the previous dose during the first 4 days after

ALL: Acute lymphoblastic leukaemia; Allo: Allogeneic; AML: Acute myeloid leukaemia; Auto: Autologous; GM: Galactomannan; GVHD: Graft-versus-host- disease; HM: Haematological

This booklet has been produced by Nursing Services in the Irish Cancer Society to meet the need for improved communication, information and support for cancer patients and

ABL1: Abelson murine leukaemia viral oncogene homolog 1; AKT: protein kinase B; ALL: acute lymphoblastic leukaemia; AML: acute myeloid leukaemia; Ang1: angiopoietin 1;

Table 2.3 : Morphologic characteristic of blast cells in acute lymphoblastic leukaemia versus acute myeloid leukaemia. Adapted from (Chiaretti et al.