[PDF] Top 20 Role of hepatic transport proteins in drug disposition and drug-induced liver injury

... The role of various transport proteins in the biliary excretion of phase II metabolites has been examined using several compounds including acetaminophen, 4-methylumbelliferone and harmol, which are ... See full document

... DDIs: Drug Transporter ...of drug metabolizing enzymes as well as drug transporter ...of drug metabolizing enzymes by HIV PIs is a common mechanism underlying clinically relevant PI-associated ... See full document

... the role of this pathway, in vitro inhibitors of JAK2 could be used in conjunction with EPO to determine if EPO-mediated down- regulation of CYP3A is ...critical role in the effect ... See full document

... to proteins in the mitochondria, which are important in regulating cell death (Tirmenstein, Nelson ...human liver microsomes, human hepatocytes and rat liver in vivo (Nakayama et ...the drug, ... See full document

... the liver. Processes that have been shown to play a role in the mechanism leading to injury progression include covalent binding to cellular proteins, oxidative stress, apoptosis, necrosis, ... See full document

... structural proteins to the complete sets found in adult cells will dramatically increase the utility of stem cell ...full hepatic functionality with respect to drug metabolism, transporter expression ... See full document

... of hepatic transaminase enzymes and other proteins, such as bilirubin, are taken to represent breakdown of cell disruption or organelle damage by either apoptotic or necrotic ...cytotoxic injury, but ... See full document

... and proteins, blood coagulation and ...important role in detoxification processes and also an important role in synthesizing useful ...the liver inflicted by hepatotoxic agents is of grave ... See full document

... lipids, proteins and nucleic acids. d-GalN application caused a hepatic lipid peroxidation manifested by the production of MDA and depletion of hepatic ...in liver which plays a key ... See full document

... key role in inflammatory signalling by acting as a chemoattractant for immune cells through interaction with CXCL12 and signalling via CXCR4 (Venereau et ...pivotal role that redox has in the coordination ... See full document

... example, it protects against free radicals produced by xenobiotics or their metabolites. It is capable of binding to potentially harmful electrophilic compounds through two mechanisms: first, it can protect protein ... See full document

... chronic liver disease, extensive damage occurs in hepatocytes that promotes different mechanisms of removal and repair of damaged cells depending on the stage of the ...process, hepatic progenitor cells ... See full document

... partner. If the patient is critically ill and in an unusual en- vironment, they may be more prone to medication error. If the pump is under the care of a mixing partner, they may be unavailable to change the medication ... See full document

... of liver parameters and considering the possibility of thyrotoxicosis in association with hepatotoxicity induced by propylthiouracil, she underwent plasmapheresis, followed by urgent thyroidectomy, and ... See full document

... The variety of HLA genotyping techniques used (such as serological and sequence based HLA typing), genotype resolution and partial reporting of genotypes may all contribute to the differences in associations described. ... See full document

... occasionally liver specific symptoms (jaundice, pruritus, encephalopathy, and ascites) in severe ...a drug related eosinophilic systemic syndrome (DRESS) presentation will make drug hepatotoxicity ... See full document

... Aniline analgesics, antibacterial agents excluding flu- cloxacillin, NSAIDs, platelet aggregation inhibitors exclud- ing heparin, vitamin B12, and thiazides were the drug classes included for comparison between ... See full document

... of hepatic damage observed is significant decrease in serum protein level in ethanol treated ...in liver weight showed by alcohol treated rats was also cured by ...the liver weight by blocking the ... See full document

... acute liver failure in adults and paediatric ...acute liver failure, NAC was associated with an improvement in transplant-free survival in a subgroup of patients with grade 1 and grade 2 encephalopathy ... See full document

... 46. Mahmoud LB, Ghozzi H, Kamoun A, Hakim A, Hachicha H, Hammami S, et al. Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in ... See full document