Top PDF Role of Interleukin-2 and Herpes Simplex Virus 1 in Central Nervous System Demyelination in Mice
Role of Interleukin-2 and Herpes Simplex Virus 1 in Central Nervous System Demyelination in Mice
... System Demyelination in Mice Kevin ...of mice with recombinant herpes simplex virus 1 (HSV-1) constitutively expressing interleukin-2 ...
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Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus types 1 and 2.
... On the other hand, a TK- mutant of HSV-2 was far less pathogenic for mice by either route of infection than the parental TK+ virus was; no mice died, even after intracere- bral inoculati[r] ...
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Gene transfer into the central nervous system using Herpes Simplex Virus-1 vectors
... the nervous system within the context of the HSV-1 ...of 2–10 days ...Leukemia Virus (MoMuLV) LTR has been demonstrated, how- ever, to afford long-term expression of b-galactosi- dase ...
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Molecular Diagnosis of Herpes Simplex Virus Infections in the Central Nervous System
... type 1 (HIV-1) infection, both in vitro and in vivo, has been associated with an internal 32-bp deletion in the human CC-chemokine receptor 5 gene (23, 87) and mutations in the promoter region which are ...
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Role of Specific Innate Immune Responses in Herpes Simplex Virus Infection of the Central Nervous System
... in mice deficient in specific innate immunity ...in mice because it allows analysis of CNS infection solely, separate from the effects in other ...of virus are needed for rapid and reproducible onset ...
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Involvement of Apolipoprotein E in the Hematogenous Route of Herpes Simplex Virus Type 1 to the Central Nervous System
... of virus in hemizygotes was between that in wild-type and in knockout mice, indicating that the level of ApoE present and HSV-1 invasiveness in the brain are ...the virus to survive in a ...
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Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review
... beneficial role of adjuvant steroids in HSE, which may re- strict detrimental immune responses by mechanisms such as inducing apoptosis of immune cells in peripheral blood and within the CNS, or neutralization of ...
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A Central Role for CD4+ T Cells and RANTES in Virus-Induced Central Nervous System Inflammation and Demyelination
... ating demyelination early in the infection, which is consistent with what we have ... 2 -microglobulin ko mice (lacking major histocompatibility complex class I and having low numbers of CD8 ⫹ T ...
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Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome.
... Localization of herpes simplex virus in the trigeminal and olfactory systems in the mouse central nervous system during acute and latent infections by in situ hybridization. Pathogenesis[r] ...
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Herpes Simplex Virus Central Nervous System Relapse During Treatment of Infantile Spasms With Corticotropin
... Corticotropin therapy has been linked in other cases to herpes family virus reactivation and disease. Cortico- tropin use in a patient for opsoclonus led to fatal, dis- seminated HSV infection that did not ...
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Efficient Reactivation of Latent Herpes Simplex Virus from Mouse Central Nervous System Tissues
... latent herpes simplex virus (HSV) reactivates efficiently from ganglia, but rarely from the central nervous systems (CNS), of mice when assayed by mincing tissues before explant ...
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The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice Is a Major Cause of Central Nervous System Pathology Resulting in Fatal Encephalitis
... B6-E mice receiving transplants are also re- flected in differences of HSV replication, eye swab cultures were obtained daily after HSV inoculation by the corneal ...Table 2 and ...B6-E mice ...
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The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1.
... of virus. Male 4- to 5-week-old CBA/J mice were anesthetized with a mixture of ketamine and acepromazine (12 mg and ...at 2 units, nose down from zero, for all ...the virus or marker solution ...
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Functional Genomics Reveals an Essential and Specific Role for Stat1 in Protection of the Central Nervous System following Herpes Simplex Virus Corneal Infection
... the central nervous system from an acute neurotropic virus ...Stat1-deficient mice to CNS pathology was mirrored in gene signatures that predicted significant per- meability of the ...
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Phosphorylation of a Herpes Simplex Virus 1 dUTPase by a Viral Protein Kinase, Us3, Dictates Viral Pathogenicity in the Central Nervous System but Not at the Periphery
... of mice following ocular, ear, or vaginal inoculation, respectively (49, ...of mice but not for infection of peripheral ...ver virus (ASFV), encode dUTPases in addition to herpesviruses (29, ...
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Interferon Regulatory Factor 3-Dependent Pathways Are Critical for Control of Herpes Simplex Virus Type 1 Central Nervous System Infection
... the virus gains its foothold, and the result is increased susceptibility to HSV-1 CNS ...critical role for IRF-3 in the brain following HSV-1 ...and mice lacking these components are ...
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Hematogenous Vertical Transmission of Herpes Simplex Virus Type 1 in Mice
... 2005 Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that causes severe disease and death in newborn humans but, to date, it remains unclear how neonatal infection ...
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Critical Role for Protein Tyrosine Phosphatase SHP-1 in Controlling Infection of Central Nervous System Glia and Demyelination by Theiler's Murine Encephalomyelitis Virus
... the central nervous system ...the role of SHP-1 in virus infection of glia and virus-induced demyelination in the ...SHP-1-deficient mice and their ...
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Role of Dendritic Cells in Enhancement of Herpes Simplex Virus Type 1 Latency and Reactivation in Vaccinated Mice
... nated mice. In this study, the depletion of DCs from latently infected mice that were immunized with 5gP DNA reduced the level of LAT in TGs by fivefold and, in the control vector- immunized group, the ...
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Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1.
... some role during ...of mice deficient in IFN- g or the IFN- g receptor (IFN- g R) are consis- tent with a role for IFN- g in limiting HSV replication at the acute ...
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