[PDF] Top 20 The role of interleukin 1 in the pathogenesis of human intervertebral disc degeneration
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The role of interleukin 1 in the pathogenesis of human intervertebral disc degeneration
... morphological degeneration according to previ- ously published criteria ...of degeneration within a disc: scores of 0 to 3 represent a histologically normal (non-degen- erate) disc; 4 to 6, ... See full document
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The role of interleukin 1 in the pathogenesis of human Intervertebral disc degeneration
... IL- 1 and its inhibitor, IL-1Ra, ensuring that matrix homeostasis is ...of human IVD cells with IL-1 disturbs the normal balance of catabolic and anabolic events, with the result that degrading ... See full document
14
Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration
... The intervertebral disc (IVD) is composed of a central gel- atinous nucleus pulposus (NP), a peripherally located an- nulus fibrosus (AF), and the cranial and caudal cartilaginous endplates associated with ... See full document
13
Original Article HtrA1 up-regulates expression of MMPs via Erk1/2/Rock-dependent pathways
... potential role of a high temperature require- ment A1 (HtrA1) in intervertebral disc degeneration ...regulatory role of HtrA1 in the pathogenesis of ...of human ... See full document
11
Expression and Role of Sphingosine 1-Phosphate Receptors in Intervertebral Disc Degeneration
... While, other effects of S1P in chondrocyte have also been reported [11, 22]. Notably, Masuko`s study drew the conclusion Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of ... See full document
7
Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc
... Introduction: Intervertebral disc (IVD) degeneration is considered a major underlying factor in the pathogenesis of chronic low back ...during degeneration there is ingrowth of ... See full document
11
Caveolin 1 expression and stress induced premature senescence in human intervertebral disc degeneration
... In human endothelial cells, iso- lated from atherosclerotic patients and induced to senesce, caveolin-1 expression was correlated with senescence biomarkers and with expression of 4-hydroxynonenal expres- ... See full document
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Interleukin 1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study
... of human IVD have studied herniated tissue; however, herniated tissue is not believed to be the seat of the processes of ...of degeneration, localize matrix degrading activity within the NP and AF, and ... See full document
13
VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process
... The degeneration of IVD is associated with vasculari- zation and innervation ...receptor 1 (mVEGFR1), while shorter soluble forms of this receptor (sVEGFR1) behave as competitive inhibitors of ...essential ... See full document
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Original Article Downregulated interleukin 37 expression associated with aggravation of intervertebral disc degeneration
... Abstract: Interleukin 37 (IL-37) is an anti-inflammatory cytokine which was proven to be associated with several dis- eases characterized with ...of Intervertebral disc degeneration (IVDD) is ... See full document
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Development of Human Interleukin-6 electrochemical Immunosensor Based on Pt-Pd Nanocomposite for Evaluation of Intervertebral Disc Degeneration
... However, the current decreased when prolonging the immersion time, which could be induced by the deactivation of the protein. Hence, 45 min was considered as the optimum immersion time to detect the target protein ... See full document
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Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration
... IVD degeneration can also further disrupt the osmotic flux of the ...IVD degeneration [21], which is characterised by altered biomechanical properties of the spine caused by an imbalance between anabolic ... See full document
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Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
... cytokines interleukin-1-beta (IL-1β) and tumour necrosis fac- tor-alpha (TNF-α) ...in disc degeneration and shown that IL-1α, IL-1β, IL-1 receptor 1 (IL-1R1) and IL-1 ... See full document
10
Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
... of disc cells, Sarah Heathfield for assist- ance with data analysis, and Basem Abdallah and Moustapha Kassem for the kind gift of the hTERT primers and positive ...the Human Tissue Profiling Laboratories of ... See full document
12
Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
... of disc cells, Sarah Heathfield for assist- ance with data analysis, and Basem Abdallah and Moustapha Kassem for the kind gift of the hTERT primers and positive ...the Human Tissue Profiling Laboratories of ... See full document
13
A Dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine
... classify disc degeneration by varying grades of joint space narrowing, osteophytes and endplate sclerosis [6, ...lumbar disc degeneration, Pfirrmann’s method (2001) [8] was endorsed as a valid ... See full document
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The role of PHD2 mutations in the pathogenesis of erythrocytosis
... Indeed, many HIF target genes are involved in cell proliferation and survival, such as angiogenesis (vascular endothelial growth factor and platelet derivative growth factor), cell proliferation (transforming growth ... See full document
20
TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway
... in 1× binding buffer at a concentration of 1 × 10 6 ...of 1× binding buffer was added into each tube, and flow cytometry analysis was performed within 30 ... See full document
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The effects of human Wharton’s jelly cell transplantation on the intervertebral disc in a canine disc degeneration model
... IVD degeneration- related diseases before the ...induce disc degeneration, an 18-gauge needle was inserted at the center of the disc through the annulus fibrosus (AF) into the ...single ... See full document
15
Bovine explant model of degeneration of the intervertebral disc
... Intact motion segments were injected with a radio-opaque solution (Omnipaque, Amersham, Buckinghamshire) before X-raying (32 kV for 80 seconds exposure) and then dissected using a band saw. The volume injected was ... See full document
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