[PDF] Top 20 The role of P63 in cancer, stem cells and cancer stem cells

... of p63-/- mice undergoes an unusual process of non-regenerative ...hypothesis, p63 is proposed to be essential for specification and differentiation of stratified epithelial cells [74, ...hypothesis, ... See full document

... the cancer treatment is targeted at its prolifera- tion potential and its ability to metastasise, and hence the majority of treatments are targeted at rapidly dividing cells and at molecular targets that ... See full document

... of stem cell markers/factors as well as prosurvival pathways, including autophagy(Heddleston et ...pancreatic cancer stem cells(Zhu et ...a role of autophagy in the adaptation of CSCs ... See full document

... several cancer-related signaling path- ways, including Bmi-1 [54], Wnt/β-catenin [55], Notch [56], and Sonic Hedgehog [55,57] (Figure ...hematopoietic stem cells ...hematopoietic stem ... See full document

... form cancer cell and helps in the genera- tion of self-sustaining growth mechanism which leads to the development of tumors as well as cancer ...of cancer stem ...of cancer stem ... See full document

... of p63, which is a mem- ber of the p53 protein family with diverse roles in carcinogenesis that include tumor- suppressing and oncogenic effects [1 – ...link p63 with STAT3 that is one of the seven members ... See full document

... important role in lymph-node metastasis and in the potential carcinoge- nicity of certain forms of T-cell leukemia and ...T cells by increasing their resistance to apoptosis induced experimentally by ... See full document

... and p53 proteins are commonly found to be non-functional in many types of cancer (Hanahan and Weinberg 2011). The pRb responds to many intra and extracellular stimuli for G1 cell cycle arrest (Weinberg 1995), ... See full document

... intestinal stem cell (ISC)-enriched cell populations ...in cells with high expression of both Lgr5 and EphB2 receptor, supporting that USP54 expression is upregulated in intestinal cells with ... See full document

... to cancer stem cells (CSCs), a minor primary tumor subset seeming to play a leading role in the self- maintenance and metastasis of ...tumor cells and normal stem cells, ... See full document

... in cancer development, we fi rst examined the expression level of PTPRU in color- ectal and gastric cancer ...in cancer tissues, which indi- cated that PTPRU may play a tumor suppressor role in ... See full document

... important role in resistance ...malignant cells’ production. These undifferentiated cells have a crucial role in the flunk of radio- iodine ...T cells, are different ways to destroy ... See full document

... cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative ...using stem ... See full document

... the role of PcG in deterring tumor development, upregulation of EZH2 leads to aggressive progression of both breast and prostate cancers ...glioma stem cell genes and inhibits glioblast- oma formation in ... See full document

... MSC, cells were stained with rat anti-mouse CD29 (BD Biosciences Pharmingen, San Diego, CA) and CD45 (BD Biosciences Pharmingen, San Diego, ...CD206-positive cells was determined by counting the number of ... See full document

... contain stem or progenitor cells that might contribute some or all of the neural crest derivatives shown previously to arise from the late-emigrating population of neural crest cells (Korade and ... See full document

... epithelial cells, cancer stem cells, carcinoma cells and embryonic stem ...epithelial cells, EpCAM is localized to the basolateral membranes, whereas on carcinoma ... See full document

... of cancer stem cells or stem cell-like cells to ...the cancer stem cells from leukemia displayed the resistance to duanorubicin and Ara-C 153 ...Similarly ... See full document

... breast cancer susceptibility genes such as ...breast cancer susceptibility genes, however, such an approach may be unacceptable, and therefore in the longer term it is desirable to develop methods ... See full document

... tate cancer demonstrate that QD probes could accumu- late at tumor sites through passive and active targeting ...of cancer cells under in vivo condi- tions ...Most cancer cells have ... See full document