[PDF] Top 20 The role of the P2X7 receptor in infectious diseases

... continue producing nitric oxide, whereas cells with functional receptors are able to regulate nitric oxide production. Figure 1 presents a possible molecular explanation. CREB [64] is a transcription factor that has been ... See full document

... aims: Infectious diseases are disorders caused by organisms such as bacteria, viruses, fungi or parasites ...complex role in the outcome of specific immune ...the role of these cells in ... See full document

... whether P2X7 is upstream of OC-STAMP or at which stage of the fusion and multinucleation process the P2X7 receptor is involved ...the P2X7 receptor siRNA experiments, it is not clear if ... See full document

... TNF-α receptor 2 (sTNFR2) from alveolar macrophages which inactivates TNF-α, thus inhibiting TNF-α-dependent apoptosis and ultimately favouring mycobacterial growth ... See full document

... The immune system consists of two main components, the innate and the adaptive immunity. This complex network relies on the balance between pro-, and anti- inflammatory mechanisms. The innate immunity recognizes a broad ... See full document

... Containment of an EID outbreak involves several steps including: isolation of infectious patients, quarantine measures per local health authority recommendations, and environmental controls to prevent ... See full document

... The P2X7 receptor is an ATP-gated ionotropic channel that plays an important role in inflammation, pain and bone adaptation responses (Volonte et ...2009). P2X7 become active (opens) after ... See full document

... Converging evidence from different laboratories show that both P2X7RA and B are endowed with a strong growth-promoting activity [10,13,44,45], and in particular P2X7RA is overexpressed in many human malignant tumours ... See full document

... of infectious diseases is a complex and multi-factoral subject [16, 151, ...of infectious diseases – how the number of individuals infected changes dynamically over ...vital role in ... See full document

... osteoclasts. P2X7 receptor antagonists ...the P2X7 receptor contributes to extracellular ATP levels in osteo- clast and osteoblast cultures, suggesting an important additional role for ... See full document

... [35]. P2X7–mediated micro- vesicle formation and shedding might be a crucial pathway for secretory protein release from ...IgE receptor) are involved in the adhesive interaction and rolling behavior of ... See full document

... key components of the purinergic component of the innate immune response; among these are the absence of functional hP2X4Rs in the cell surface membrane and the lack of pro- and mature IL-1β in cell lysates. The pres- ... See full document

... to infectious blood or body fluids. It is highly infectious, can be transmitted in the absence of visible blood, and remains viable on environmental surfaces for at least seven days ... See full document

... Although there are several experiments to the contrary, the weight of evidence in the literature indicates that ACTH and cortisone either have no effect on antibody formation, or may, af[r] ... See full document

... The apparent increase of new infections as a proportion of total diagnoses in the first semester of 1995 (83, 32 per cent) compared with the first semester of 1994 (68, 29 per cent) was [r] ... See full document

... This is defined as the occurrence of syphilis in children under the age of one yean Two cases have been notified for 1992, one from Western Sydney Area Health Service in January, and the[r] ... See full document

... However, in the last quarter of 1994 three isolates from two patients had very high levels of quinolone resistance and those infected with these types of gonococci usually did not respon[r] ... See full document

... The epidemic was centred in the Bega Valley area, with 43 per cent of known cases occurring in students at Bega High School.. The outbreak peaked during the week beginning September 25, [r] ... See full document

... INTERPRETING TRENDS IN HEPATITIS C NOTIFICATIONS The NSW Health Department receives notifications for acute disease (an indicator of incident cases), and for unspecified illness (an indi[r] ... See full document

... NSA Northern Sydney Health Area, CCA Central Coast Health Area, ILL lilawarra Health Area, HUN Hunter Health Area, NC North Coast Health Region. ND Northern District Health Region, WNS W[r] ... See full document