[PDF] Top 20 Role for protease activity in visceral pain in irritable bowel syndrome

... proteolytic activity in control biopsies had no effect on colonic sensitivity to colorectal ...proteolytic activity released by IBS biopsies provoked allo- dynia and visceral hyperalgesia (Figure ... See full document

... of visceral pain at the level of thalamus, limbic system and ...of visceral pain. The role of limbic system is not clearly understood, but there are studies, which support the ... See full document

... pivotal role in activating HPA 7 . In addition to role of CRF in altering gastrointestinal motility, it is also involved at the central nervous system level in the modulation of visceral ... See full document

... Neural pathways play a major role in modulating symptoms of IBS especially the experience of pain. Spinothalamic tracts provide information that is largely directed to the primary somatosensory cortex and ... See full document

... doubt. Visceral hypersensitivity usually demonstrated by assessing the response to balloon inflation in the rectum or elsewhere, is a common phenomenon in ...chest pain. (14) Visceral ... See full document

... here we analyse a subset of 79 with complete data. There was, however, no signi fi cant difference in demographics and symptom severity from those who did not provide complete data (see online supplementary table S1 ... See full document

... Current evidence does lend support to an inflamma- tion–immunological etiopathogenesis of IBS. The various pathways discussed in this review are illustrated in Figure 1. Although a definite and reproducible pattern of ... See full document

... chronic pain and several degenerative diseases [30,31]. The role of diet in IBS remains to be ...motor activity, via excessive activation of vagal mechano- and chemo-receptors ...a role in IBS ... See full document

... Irritable bowel syndrome (IBS) is a chronic and episodic gastrointestinal (GI) ...abdominal pain/discomfort, bloating, and altered bowel function, with the predominant bowel ... See full document

... Diarrhea-predominant irritable bowel syndrome (IBS-D) belongs to the group of functional gastrointestinal disorders and is characterized by abdominal pain in conjunction with ... See full document

... (IBS)-like symptoms [5], which is more than twice as high as the prevalence in a normal population [6]. However there is some evidence that IBS-like symptoms in patients with UC may be due to inflammatory activity ... See full document

... Alteration of the indigenous gut microbiota in the pathogenesis of IBS is not only related to the types of microorganisms comprising the microbiota but also to their numbers. SIBO has been suggested to play a role ... See full document

... pelvic pain”, “chronic pain”, “dysmenorrheal”, “nonmenstrual pelvic pain”, and ...pelvic pain affects 4%–25% of women of reproductive ...as irritable bowel syndrome or ... See full document

... Background: Current knowledge suggests that small intestinal overgrowth participates in the pathogenesis of irritable bowel syndrome. It is questionable if this association is modulated by intake of ... See full document

... One of the major factors that influence develop- ment and exacerbation of FAPD is psychological stress [1, 5, 11, 25]. Experimental studies suggested involvement of the emotional motor system, for ex- ample the amygdala, ... See full document

... The study designs considered relevant to this review include cross-sectional studies, case-control studies, cohort studies and randomised controlled trials. Qualita- tive studies will be excluded. We will exclude ... See full document

... a pain diary 3 times a day (on awakening, after lunch, and evening) for 2 ...rated pain intensity by using a visual analog scale (VAS) by marking their pain rating on a 100 mm horizontal line ... See full document

... Also, the Europeans Medicines Agency (EMA) in January 2014 finalized a new guideline about medical products pro- posed for IBS treatment. Based on Rome III criteria, two co- primary endpoints – that is, abdominal ... See full document

... inflammatory bowel disease, irritable bowel syndrome, acute gastroenteritis, lactose.. intolerance and colon cancer.[r] ... See full document

... IBS modelling, and can be returned to normal after 2-week HPM treatment. Notably, aspartate is one of the major sources of ATP in mammalian enterocytes via mitochondrial oxidation [38] and play a critical role in ... See full document