Top PDF Role of Pseudorabies Virus Us3 Protein Kinase during Neuronal Infection
Role of Pseudorabies Virus Us3 Protein Kinase during Neuronal Infection
... capsid during transport to the nucleus, places it in a prime position to modulate entry events ...(23). Us3 could affect general processes at entry, such as tegument uncoating or processes leading to capsid ...
12
Different Patterns of Neuronal Infection after Intracerebral Injection of Two Strains of Pseudorabies Virus
... of infection after intracerebral injection of PRV- Becker and PRV-Bartha are consistent with the strain-depen- dent differences in viral replication observed in other ...alphaherpes- virus strains, only a ...
8
Human neuronal cell protein responses to Nipah virus infection
... human neuronal cells. The specific roles of these proteins in NiV infection are presently ...G protein, however, is usually peripherally associated with the plasma membrane and plays important ...
9
Pseudorabies Virus Tegument Protein Us2 Recruits the Mitogen-Activated Protein Kinase Extracellular-Regulated Kinase (ERK) to Membranes through Interaction with the ERK Common Docking Domain
... pathogen pseudorabies virus (PRV) is a well- studied alphaherpesvirus whose analysis has contributed greatly to our understanding of the molecular and cellular biology of virion assembly, as well as how ...
11
Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a
... The kinase activity of PRV US3 and cellular PAKs are re- quired for increased CD300a binding and modulation of PS ex- posure on the cell ...PRV US3 is a viral serine/threonine protein ...
12
The Attenuated Pseudorabies Virus Strain Bartha Fails To Package the Tegument Proteins Us3 and VP22
... The Us3 gene encodes a serine/threonine kinase (11, 28) that has many roles during viral ...the Us3 gene product is involved in virion mor- phogenesis, specifically aiding in the deenvelopment ...
12
Herpes Simplex Virus 1 Protein Kinase Us3 and Major Tegument Protein UL47 Reciprocally Regulate Their Subcellular Localization in Infected Cells
... recombinant virus with a UL47 S77A muta- ...viral infection may play a role in keeping UL47 in the cytoplasm of infected cells ...by Us3 optimally regulated its localization in infected ...
15
Differences in the Regulatory and Functional Effects of the Us3 Protein Kinase Activities of Herpes Simplex Virus 1 and 2
... HSV-1 Us3 catalytic activity is required for induction of posttranslational modification of HDAC2 and for that of wild-type HSV-1 CPEs at 24 h postin- fection ...the role of HSV-2 Us3 kinase ...
11
Role of Pseudorabies Virus Us9, a Type II Membrane Protein, in Infection of Tissue Culture Cells and the Rat Nervous System
... transneuronal infection following either intravitreal or intracranial ...direct infection of the retina, PRV 160 and PRV 161 both exhibited an anterograde neuronal spread ...central infection ...
12
Induction and Inhibition of Apoptosis by Pseudorabies Virus in the Trigeminal Ganglion during Acute Infection of Swine
... The protein ki- nase encoded by the PRV Us3 gene and expressed during productive infection (42, 47) might have an antiapoptotic func- tion in this virus, as it does in HSV-1 and HSV-2 ...
11
The US3 Protein of Pseudorabies Virus Drives Viral Passage across the Basement Membrane in Porcine Respiratory Mucosa Explants
... important role in transmigration of cells across the BM during physiological and pathological ...the US3 protein kinase of the alphaherpesvirus pseudorabies virus (PRV) ...
6
The US3 Protein Kinase Blocks Apoptosis Induced by the d120 Mutant of Herpes Simplex Virus 1 at a Premitochondrial Stage
... mutant virus- infected cells (9). The protein accumulates initially in nuclei, but early in infection it is translocated into vesicle-like struc- tures in association with proteasomes (15, ...d120 ...
7
Insertions in the gG Gene of Pseudorabies Virus Reduce Expression of the Upstream Us3 Protein and Inhibit Cell-to-Cell Spread of Virus Infection
... of infection between cells. The data so far suggest that Us3 functions in the spread of viral infection between MDBK or GBK ...of infection in MDBK and GBK ...the role of gE/gI versus ...
14
Regulation of the Catalytic Activity of Herpes Simplex Virus 1 Protein Kinase Us3 by Autophosphorylation and Its Role in Pathogenesis
... of Us3 antiapoptotic ...the Us3 null mutant virus R7041 ...the Us3-S147A and Us3-K220M mutations on virus growth in the tear film of mice following corneal ...
11
Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral dUTPase and Regulates Its Catalytic Activity in Infected Cells
... simplex virus 1 (HSV-1) is one of the best-character- ized members in the subfamily Alphaherpesvirinae of the family Herpesviridae and is the etiologic agent of a variety of diseases in humans, such as ...
12
Herpes Simplex Virus 1-Encoded Protein Kinase UL13 Phosphorylates Viral Us3 Protein Kinase and Regulates Nuclear Localization of Viral Envelopment Factors UL34 and UL31
... functional Us3 protein (61, 62, ...mutant virus with respect to UL34 and UL31 localization is similar to that of the Us3 deletion ...phosphorylates Us3 in infected cells, a reasonable ...
11
Protein Kinase R Is a Novel Mediator of CD40 Signaling and Plays a Critical Role in Modulating Immunoglobulin Expression during Respiratory Syncytial Virus Infection
... critical role in humoral immune responses by making antibodies to identify and neutralize pathogens such as viruses and ...(CSR). During CSR, the constant heavy chain of an antibody is changed from the ...
7
The Alphaherpesvirus Serine/Threonine Kinase Us3 Disrupts Promyelocytic Leukemia Protein Nuclear Bodies
... tegument protein ICP0 possesses E3 ubiquitin ligase activity (6, 18, 28, 45) that, de- pending on the particular ICP0 orthologue, leads to the deg- radation of antiviral proteins that can suppress viral gene ex- ...
11
In Transduced Cells, the US3 Protein Kinase of Herpes Simplex Virus 1 Precludes Activation and Induction of Apoptosis by Transfected Procaspase 3
... The protein concentrations of the supernatant fluids were determined with the aid of a Bio-Rad protein ...assay. Protein samples denatured in disruption buffer (50 mM Tris, pH ...CA). Protein ...
7
Role of macrophages during Theiler's virus infection.
... the virus persists is an important issue that has not been satisfactorily solved, although several papers have been published on the ...the role played by particular target cells in viral persis- ...the ...
5
