18 results with keyword: 'role vhl clear renal carcinoma relation targeted therapy'
The basic biology underlying the development of clear-cell renal cell carcinoma (ccRCC) is critically dependent on the von Hippel–Lindau gene (VHL), whose protein product is
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Keywords: clear cell renal cell carcinoma; tumor evolution; tumor ecology; intratumor heterogeneity; multisite tumor sampling; targeted
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RCC: renal cell carcinoma; ccRCC: clear cell renal cell carcinoma; mRCC: meta- static renal cell carcinoma; VHL: von Hippel–Lindau; HIFs: hypoxia-inducible factors; EGF:
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Regulation of VCAM-1 levels through a VHL-PHD-NF κ B-dependent pathway and its role in the immune response against clear-cell renal cell carcinoma.. VHL loss, hypoxia and
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von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal
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Sarcomatoid features, necrosis, and grade are prognostic factors in metastatic clear cell renal cell carcinoma with vascular endothelial growth
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Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted
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Clear cell renal cell carcinoma, tumor evolution, tumor ecology, intratumor heterogeneity, multisite tumor sampling, targeted therapy.. Distributed under a Creative Commons CC
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Recently, a study has demonstrated elegantly that HIF effects on c-myc could distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma :
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Metastatic non clear cell renal cell carcinoma (nccRCC) treated with targeted therapy agents: Characterization of survival outcome and application of the International mRCC
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We report that in hepatocellular carcinoma and clear cell renal carcinoma cells, increased activity of hypoxia-inducible factors (HIFs) due to hypoxia or VHL
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|| Grade 1 and 2 were combined and used as reference in univariate and multivariate analysis. Grade was encoded as an ordinal variable with
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Real-time quantitative PCR results showed that TET1 mRNA levels were significantly lower in RCC than matched adjacent benign tissues, while TET2 expression did not differ between
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although our goal was to identify a new HIF2α inhibitor, we characterized the expression status of both HIF1α and HIF2α in 15 VHL-deficient clear cell kidney cancer cell lines and
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The rationale of using sequential therapy for treating progressing mRCC was evaluated in several trial including: RECORD-1 (Renal Cell cancer treatment with Oral RAD001 given
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Enterprise Applications are complex software packages that manage the core enterprise business functions—Enterprise Resource Planning (ERP)—as well as the extended enterprise —
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Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma.. Rioux-Leclercq N, Fergelot
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Longitudinal study on torque transmitted from denture base to an abutment tooth of lower distal-extension removable partial dentures with conus crown telescopic system.
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