Randomized trial of safinamide add-on to levodopa in Parkinson’s disease with motor fluctuations. Borgohain R, Szasz J, Stanzione P,

Safinamide as monotherapy and as an adjunct to dopamine agonists improves Unified Parkinson’s Disease Rating Scale motor scores.. One randomized, placebo-controlled

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Randomized, double-blind, placebo-controlled, dose- finding study Monotherapy or adjunct therapy to stable single DA 172 early PD patients (56 per group of treatment) Proportion

Post hoc analysis showed the 100mg/day dose was associated with lowered intervention rate with dopamine therapy and improved UPDRS scores (secondary outcomes)

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Reduction of LD dose possible Few dropouts and no safety concerns SETTLE efficacy and safety of S (NCT00627640) [80,81] Phase III PC 24 weeks 549 50 100 Advanced PD: add-on therapy to

Safinamide as an add-on therapy to a stable dose of a single dopamine agonist: results from a randomized, placebo-controlled, 24-week multicenter trial in early

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Safinamide as an add­on therapy to a stable dose of a single dopamine agonist: results from a randomized, placebo­controlled, 24­week multicenter trial in early idio­ pathic

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