[PDF] Top 20 Kaposi’s Sarcoma Associated Herpesvirus Increases PD L1 and Proinflammatory Cytokine Expression in Human Monocytes
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Kaposi’s Sarcoma Associated Herpesvirus Increases PD L1 and Proinflammatory Cytokine Expression in Human Monocytes
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with the human malignancy Kaposi’s sarcoma and the lymphoproliferative disorders primary effusion lymphoma and ... See full document
13
Ghrelin inhibits leptin and activation induced proinflammatory cytokine expression by human monocytes and T cells
... from human donors were found to constitutively express low levels of endogenous ghrelin, which is significantly increased upon cellular ...the expression and secretion of the mature form of ghrelin from T ... See full document
11
Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy
... immune response through pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and lead to the production of interferon and proinflammatory cyto- kines. It is ... See full document
12
Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Monocytes Downregulates Expression of Adaptive Immune Response Costimulatory Receptors and Proinflammatory Cytokines
... cells, monocytes, and epithelial and endothelial ...duced expression of several cellular proteins involved in inflam- mation and immunity, compared to expression in uninfected ... See full document
8
Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
... In the context of latently infected PEL, we found that the multiple LANA complexes coexist. Purification over Sepha- rose and Heparin columns facilitated the isolation of distinct LANA complexes that were comprised of ... See full document
11
Rapidly progressive Kaposi’s Sarcoma in an Iraqi boy received Valproic acid: a case report and review of literature
... Kaposi’ s sarcoma (KS), an endothelial neoplasm, was first reported by Moritz Kaposi in 1872 ...KS-associated herpesvirus, also known as human herpesvirus (HHV) -8, ... See full document
7
Differential Expression of Viral Bcl-2 Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Human Bcl-2 in Primary Effusion Lymphoma Cells and Kaposi's Sarcoma Lesions
... It has been previously shown that KSBcl-2 mRNA is only expressed in KSHV-positive PEL cell lines, such as BC3, upon 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment for 20 to 30 h (11, 16). Thus, BC3 and the ... See full document
6
Monocyte programmed death ligand 1 expression after 3–4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study
... initial proinflammatory stage, but eventually die later in a state of immunosuppression [18, ...19]. PD-1 and its ligand PD-L1 are thought to play major roles in im- munosuppressive ...the ... See full document
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Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma
... A SYBR Green real time PCR method was used to evaluate latent (ORF72 and ORF73) and lytic (K2, K8, K8.1, K10/K10.1, K10.5/K10.6 and ORF16) gene expres- sion in biopsies and PBMCs. Specially, oligoprimers were designed ... See full document
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Classic Kaposi Sarcoma in 3 Unrelated Turkish Children Born to Consanguineous Kindreds
... of Human Genetics of Infectious Diseases is supported by grants from INSERM, University Paris Descartes, the Agence Nationale pour la Recherche, the BNP Paribas Founda- tion, the March of Dimes, and the Dana ... See full document
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Original Article PD-L1 is correlated with p53 expression in patients with lung adenocarcinoma
... Abstract: PD-L1 plays a key role in immune evasion of tumor cells, and individual study found that PD-L1 status was regulated by p53 ...Whether PD-L1 expression is related ... See full document
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Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies
... FIG. 4. Mapping of the self-association domain within the C terminus. (A) Alignment of the C-terminal domains from LANA-like proteins encoded by HHV-8, Ateline herpesvirus-3 (AHV-3), herpesvirus saimiri ... See full document
9
Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects
... that PD-L1 expression in host anti- gen presenting cells (APCs), including DCs and macro- phages, plays pivotal roles in the efficacy of PD1/PD-L1 checkpoint blockade-based ... See full document
15
Nicoli, Francesco (2013): Immunomodulatory properties of the HIV-1 Tat protein. Dissertation, LMU München: Medizinische Fakultät
... Tat displays different properties depending by the concentration and localization (intra or extracellular), suggesting that it may signal through different pathways. Extracellular receptor-activated kinase (ERK) and ... See full document
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Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade
... [27]. PD-L1 expression on tumor cells and immune cells has been shown to enrich for response to anti-PD-1/ L1 in various solid malignancies ...prominent expression of two of the ... See full document
5
PD1/PDL-1 Inhibitors: Emerging Hope for Bladder Cancer
... subtypes are more significant in luminal type II. Higher mutational load in responders and those with long survival suggested mutation load positive correlation with better response and survival. Grade 3-4 TRAEs occurred ... See full document
10
Kaposi's sarcoma of the hand mimicking squamous cell carcinoma in a woman with no evidence of HIV infection: a case report
... The surgical specimen was submitted for pathological evaluation. Histological and immunohistological find- ings were consistent with a diagnosis of KS (Figure 3A and 3B). Serologic testing for HIV infection was negative, ... See full document
5
Downregulation of Gamma Interferon Receptor 1 by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5
... To further test the roles of K3 and K5 as IFN- ␥ antagonists, we measured the transcriptional activities of IFN-regulated promoters using a luciferase reporter gene. Since type I IFN- ␣ /  and type II IFN- ␥ act on ... See full document
11
Scoring of PD-L1 expression intensity on pulmonary adenocarcinomas and the correlations with clinicopathological factors
... for PD-L1 immunohistochemistry, and randomly selected the fi elds of view for assessment of PD-L1 staining intensity of pulmonary adenocarcinoma ...(83.9%), PD-L1-expressing ... See full document
8
HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
... Kaposi sarcoma–associated herpesvirus infection is associated with the development of 3 proliferative diseases: Kaposi sarcoma, primary effusion lymphoma, and multicentric ... See full document
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