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Sclerostin : a key regulator of bone metabolism

Sclerostin : a key regulator of bone metabolism

... between bone resorption and bone formation, in favor of resorption, is the predominant pathogenetic factor for bone loss while during the second, chronic, phase reduced bone formation and ... See full document

188

Association of Sclerostin with Bone Metabolism and Bone Mineral Density in Adults with Type 1 Diabetes Mellitus

Association of Sclerostin with Bone Metabolism and Bone Mineral Density in Adults with Type 1 Diabetes Mellitus

... increases bone resorption; it stimulates osteoclasts by binding to PTH receptor 1 ...decrease bone resorption by inhibiting the expression of (SOST) ...between sclerostin and iPTH is ...between ... See full document

7

Direct effects of physical training on markers of bone metabolism and serum sclerostin concentrations in older adults with low bone mass

Direct effects of physical training on markers of bone metabolism and serum sclerostin concentrations in older adults with low bone mass

... of bone resorption to external stresses, and although stimu- lation of osteoblast and/or osteoclast function is exercise- dependent the osteoblast/clast response to exercise is not immediate ...and ... See full document

8

Bone markers and cardiovascular risk in type 2 diabetes patients

Bone markers and cardiovascular risk in type 2 diabetes patients

... and sclerostin are suggested to play a role in CVD ...in bone and vascu- lar tissue, and may therefore be considered as a protec- tive factor for vascular calcification and CVD risk ...increase bone ... See full document

7

Sclerostin - a potential new marker of exercise influence on vascular calcification and mineral and bone disorder in hemodialysed adults

Sclerostin - a potential new marker of exercise influence on vascular calcification and mineral and bone disorder in hemodialysed adults

... mineral metabolism disorders occurring in progress of ESRD are also relevant, and has a prevalence rate of nearly 90% in ESRD patients ...and Bone Disorder ...of bone mineral ...with bone ... See full document

8

Sclerostin: Intracellular mechanisms of action and its role in the pathogenesis of skeletal and vascular disorders

Sclerostin: Intracellular mechanisms of action and its role in the pathogenesis of skeletal and vascular disorders

... of bone metabolism, exclusively secreted by ...of bone morphogenetic proteins (BMPs) and is an inhibitor of the Wnt/β-catenin met- abolic pathway in bone ...of sclerostin in response to ... See full document

9

PPAR γ insufficiency enhances osteogenesis through osteoblast formation 
from bone marrow progenitors

PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

... Real-time quantitative RT-PCR. Total RNA was extracted with an ISOGEN kit (Wako Pure Chemicals Industry Ltd., Osaka, Japan), according to the manufacturer’s instructions, from ES cells cul- tured for 10 days after the ... See full document

11

mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK

mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK

... Figure 3: AMPK up-regulation increases glucose metabolism and proliferation in triple negative breast cancer in vitro and in vivo. A. MDA-MB-231 and MDA-MB-468 cells were transfected with AMPK-expression vector or ... See full document

11

miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma

miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma

... energy metabolism is very common in cancer cells ...tumor metabolism, which supports tumor cells’ energy requirements, has been shown to promote the progression and metastasis of ... See full document

9

Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study

Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study

... both sclerostin and DKK-1 express Wnt antagonism, they are independ- ent (not synergistic) regulators of Wnt ...and sclerostin do not bind simultaneously to LRP5; DKK- 1 can displace sclerostin from ... See full document

10

Hepcidin: A key regulator of iron

Hepcidin: A key regulator of iron

... hepcidin secretion increases greatly by the elevated amount of iron. In patients with anaemia of inflammation caused by chronic infections or severe inflammatory diseases, a 100-fold increase in hepcidin excretion was ... See full document

5

Hepatitis B Virus X Protein Induces Hepatic Steatosis by Enhancing the Expression of Liver Fatty Acid Binding Protein

Hepatitis B Virus X Protein Induces Hepatic Steatosis by Enhancing the Expression of Liver Fatty Acid Binding Protein

... HNF3␤ and C/EBP␣ belong to the liver-enriched transcription factors families. HNF3 ␤ belongs to the HNF-3 gene family, which includes three proteins (HNF3␣, HNF3␤, and HNF3␥) that me- diate hepatocyte-enriched ... See full document

12

Intermittent PTH administration improves alveolar bone formation in type 1 diabetic rats with periodontitis

Intermittent PTH administration improves alveolar bone formation in type 1 diabetic rats with periodontitis

... and bone formation in rat tibiae, whereas continuous PTH infusion via an osmotic pump results in systemic effects, including bone resorption and bone marrow fibrosis, suggesting that intermittent PTH ... See full document

7

Role of sclerostin in the pathogenesis of chronic kidney disease-mineral bone disorder

Role of sclerostin in the pathogenesis of chronic kidney disease-mineral bone disorder

... classic bone anabolic PTH response ...on sclerostin, because sclerostin down-regulation is a classic target of β-catenin-controlled ...high bone turnover via a PTH-dependent effect on the ... See full document

8

Crystallization of the regulatory and effector domains of the key sporulation response regulator Spo0A

Crystallization of the regulatory and effector domains of the key sporulation response regulator Spo0A

... A search for heavy-metal derivatives of crystals of both the functional domains of Spo0A is now under way. In the absence of suitable crystals of the intact protein, we hope that the structures of the two domains of ... See full document

7

miR-195 is a key regulator of Raf1 in thyroid cancer

miR-195 is a key regulator of Raf1 in thyroid cancer

... occurs in ~ 40%–60% of papillary thyroid cancer, which makes the design of targeted drug more difficult. However, the characters that both the WT and the mutation type of Raf1 share a same 3 ′ UTR pushes drugs based on ... See full document

8

Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus

Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus

... cortical bone areas were analysed with CT-Analyser (CTAn) version ...and bone structure was quantified using the built-in 2D and 3D analysis software BATMAN ...trabecular bone were chosen to be ... See full document

12

Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response

Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response

... Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Ho[.] ... See full document

12

Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?

Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?

... Studies over the last decade have established LXRs as master regulators of lipid metabolism. LXR mediates activa- tion of target genes such as sterol responsive element bind- ing protein 1c (SREBP1c), a master ... See full document

14

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice

... the bone including vascular channels, osteocyte lacu- nae or ...cortical bone volume and porosity, was not suf fi cient to provide detailed information about the osteocyte ... See full document

9

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