[PDF] Top 20 Daily sedative interruption versus intermittent sedation in mechanically ventilated critically ill patients: a randomized trial

... The daily interruption group would receive sedatives (midazolam or propofol, at the discretion of the attending physician) aimed to a SAS target of 3 to 4, which means that the patient is awake or easily ... See full document

... Several sedation administration strategies have been devel- oped to reduce oversedation and duration of mechanical ventilation in critically ill ...of daily sedation interruption ... See full document

... the patients could spoil this blinding by revealing their randomization, but experience tells us that most patients are unaware as to which of the two groups they have been ...both sedation (at least ... See full document

... and patients with alcohol use disorders can develop withdrawal syndromes if they are undersedated or have early withdrawal of sedation ...in critically ill patients with alco- hol use ... See full document

... nocturnal sedation likely re- flects general clinical practice, given that SLEAP was a pragmatic trial conducted in 16 centers, and sedation was managed by bedside ICU ...in sedative ... See full document

... of sedation among the three ...of sedation of midazolam and pro- pofol (used alone or sequentially) was ...ICU patients with long-term exposure to benzodiazepine sedatives ...after ... See full document

... lower sedative drug use were observed in the intervention group, which mainly occurred in the subgroup in whom RI values were <20 at baseline, in whom there was greatest plausi- bility for an effect on clinical ... See full document

... Sixty patients admitted to the ICU with respiratory failure requiring mechanical ventilation will be randomized to one of three arms (20 participants per arm): (1) personalized music, (2) non-personalized ... See full document

... when sedation is managed with a sedation protocol that targets light ...multicenter randomized trial comparing PS with combined PS plus DSI in 423 critically ill ... See full document

... included patients who were expected to receive mechanical ventilation for more than 24 ...of sedation because of increased intracranial pressure or undergoing thera- peutic ...excluded patients who ... See full document

... the ICU and the length of stay in the hospital [6]. DSI is also a safe approach: self-extubation and removal of cathe- ters did not occur more frequently in patients treated with DSI. Follow-up studies showed that ... See full document

... Most critically ill, mechanically ventilated patients in ICUs throughout the world are still routinely ...the patients. We undertook a randomised clinical trial to as- ... See full document

... The two predictive equations with the best performance in our study were Mifflin St Jeor and Harris–Benedict. Both of these equations have the methodological prob- lem that they require a SF to account for the increased ... See full document

... Theoretically, the NMEoccl could be helpful to titrate ventilator support in patients on partially supported modes. NMEoccl is calculated by dividing ΔPaw by ΔEAdi during an end-expiratory occlusion. During an ... See full document

... in patients with brain injury, but the only fact which is generally accepted is that when the GCS score is still less than 8 points after 7 days of mechanical ventilation, early tracheotomy is recommended for ... See full document

... all randomized clinical trials, quasi-experimental studies, and observational studies published in ...adult patients in the ICU who were conscious with an oral tube or tracheostomy with inflated ...for ... See full document

... Dex can bind to the α2 adrenergic receptors in the central and peripheral nervous systems, which causes an anti-sympathetic effect and decreases the heart rate [14]. Sinus bradycar- dia is a common adverse reaction to ... See full document

... in critically ill patients with acute kidney injury ...in critically ill patients, especially in patients with acute kidney injury ...in critically ill ... See full document

... in critically ill patients treated with recombinant human EPO ...g/dl) versus a liberal (threshold 10 g/dl, goal 10–12 g/dl) transfusion strategy in critically ill ...acutely ... See full document

... 584 patients were included in the intervention group and 590 in the control ...breathing trial and time to successful extubation were significantly shorter in the intervention group than in the control ... See full document