[PDF] Top 20 Senescent cells: a therapeutic target for cardiovascular disease

... Third, and finally, the first generation of SNC-killing mole- cules have been described (see Childs et al., ref. 17, for an exten- sive overview). Existing senolytics work by targeting prosurvival adaptations that are ... See full document

... Some of the treatments that increase HDL concentrations have been shown to reduce atheroma volume and may prevent the formation of new atherosclerotic lesions, thereby reducing the risk of cardiovascular ... See full document

... vitiligo performed in animal models have shown that melanocyte-derived SDF1 plays an important role in the activation of melanocyte-specific autoimmunity and results in continuous loss of melanocytes [39]. The results of ... See full document

... Participation in high-impact physical activities, including military service and athletics, places younger patients at higher risk of developing PTOA (7–9). Damage or loss of the anterior cruciate ligament (ACL) in the ... See full document

... already-formed senescent cells, may not only reduce tissue inflammation and organ dysfunction but might also reduce cancer ...risk. Cells can become senescent when they harbor potentially ... See full document

... lial cells and the surrounding components of the CNS, including pericytes, astrocytes and the basement mem- ...immune cells into the brain ...immune cells into the CNS, which has been identified as ... See full document

... the cells [3, ...cancer cells from caspase-3 activation in vitro, indicating that small HSPs αB-crystallin is a novel inhibitor of the activation of apoptosis ... See full document

... progenitor cells (EPCs) are mobilized from bone marrow to replace the ECs sloughed off from the vascular wall as a result of either apoptosis or a trau- matic vascular injury ...any cardiovascular trauma. ... See full document

... epithelial cells [49] and the inflammatory resulting from cell necrosis may be mediated by surface IL-1α ...tubular cells was lower in IL-1RA-treated animals 24 h after ischemia, which was paralleled by a ... See full document

... heart disease and myocardial ...artery disease and acute myocardial infarction ...of cardiovascular events, and that CRP was the strongest univariate predictor of the risk of such events ... See full document

... ED also has profound effects on the development of pulmonary artery hypertension (PAH) [27,28]. Dysfunctional endothelial cell proliferation and overzealous concurrent neo- angiogenesis results in formation of plexiform ... See full document

... these cells might provide a way to treat this disease. CD13 + cells predominated in the G 0 phase of the cell cycle and typically formed cellular clusters in cancer ...these cells survived and ... See full document

... and therapeutic strategies to combat the ...for senescent cell ...surveyed therapeutic molecules targeting senescent cells drawing relevance to ...in senescent cells 4 ... See full document

... the cardiovascular developmental cascade by directly activating a wide range of genes in early embryos and later becomes silent after embryonic vessels have been ... See full document

... Electrolyte imbalances, such as reduced serum K + levels (hypokalemia), also trigger these potentially fatal arrhythmias. In this issue of the JCI, Guo et al. report that physiological levels of serum K + are required to ... See full document

... acidic fibroblast growth factor (FGF-1) and FGF-2, have a strong affinity for heparin and have been studied for their effects on vascular cells, including endothelial cells and smooth muscle cells. ... See full document

... in cardiovascular pathologies, including coronary artery disease, carotid atherosclerosis, heart failure, obesity-associated heart dysfunction, and cardiac ...dendritic cells, neutrophils, and ... See full document

... (<45 years) survivors of myocardial infarction [127] and those with recurrent MI [128]. For many years, PAI-1, produced by endothelial cells and adipose tissue, has been regarded as the main inhibitor of ... See full document

... a disease group that is clearly linked to the function of pathogenic ...agglutinin disease, approaching 85% in one prospective study ...plasma cells are not sufficient to maintain autoantibody levels ... See full document

... Despite low cellular retention and poor differentiation into cardiomyocytes, studies were still demonstrating improved heart function [27], which suggests a potential paracrine mechanism of action for transplanted MSCs. ... See full document