Top PDF Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells
Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells
... rAdV infection; rather, levels of activated IRF3 were often elevated compared to shscrambled-infected ...to activation of IRF7 and IRF5 but not IRF3. Alternatively, adenovirus escapes the endosomal ...
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Sensing Infection by Adenovirus: Toll-Like Receptor-Independent Viral DNA Recognition Signals Activation of the Interferon Regulatory Factor 3 Master Regulator
... The immune response generated against AdV following sys- temic administration is a composite response generated by a variety of cell types that recognize and respond to AdV (re- viewed in reference 41). We have utilized ...
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Adenovirus Induction of an Interferon-Regulatory Factor during Entry into the Late Phase of Infection
... Virus infection of animal cells can induce intracellular antiviral responses mediated by the induction of interferon-regulatory transcription factors (IRFs), which bind to and control genes ...
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Rhesus Cytomegalovirus Particles Prevent Activation of Interferon Regulatory Factor 3
... infected cells are potent stimulators of the immune ...of infection might or might not be beneficial for viral propagation in ...successful infection in ...
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Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF-κB and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection
... for activation of transcription factors that drive CXCL10 ...IFN-independent activation of STAT1 and STAT3 proteins during infection with dengue virus, another member of the Flaviviridae ...HCV ...
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The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3
... inhibits activation of the ISG54 ...SeV infection. In addition, infection of human-de- rived 293 cells with Ebola virus Reston did not activate the ISG54 ...
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Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 Activation
... MDV infection in chicken fibroblasts and ...IRF7 activation and resulting in inhibition of the DNA-sensing ...DNA sensing in chickens and reveal a mechanism through which MDV antagonizes the ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... RV14 infection results in altered levels of a wide variety of host mRNAs, induction of IFN-  mRNA or activation of the Jak/STAT pathway is not ...following infection. Since many viruses are known to ...
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The Host Response to West Nile Virus Infection Limits Viral Spread through the Activation of the Interferon Regulatory Factor 3 Pathway
... beta interferon (IFN-  ) and several IFN-stimulated genes late in infection of cultured human ...delayed activation of the transcription factor IFN regulatory factor 3 ...
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Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection
... the activation of IRF3 was induced by these PrP ...IRF3 activation, such as phosphorylation, dimerization, and cyto- plasm-to-nucleus translocation of IRF3 in 22L-N2a58 cells, were not detected (data ...
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Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts
... these cells and there was no detectable virus-induced cytopathic effect in the culture (data not ...MA104 cells (56, ...viral infection is not required for DC activation and type I IFN ...
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Adenovirus Infection of Human Enteroids Reveals Interferon Sensitivity and Preferential Infection of Goblet Cells
... Human enteroids. Adult human ileal tissue was acquired through NW BioTrust and NW BioSpecimen from normal, healthy tissue during surgical resections. The University of Washington Institutional Review Board has determined ...
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Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3
... The type I IFN signal pathway is the first line of host innate defense against viral infection, and it is responsible for the induc- tion of numerous ISGs. Recent research reveals that the type I IFN signal ...
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LGP2 Downregulates Interferon Production during Infection with Seasonal Human Influenza A Viruses That Activate Interferon Regulatory Factor 3
... human cells employed LGP2 overex- pression because siRNA knockdowns failed to deplete the LGP2 protein that was synthesized during influenza A virus ...human cells infected with seasonal influenza A viruses ...
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Interferon Regulatory Factor 3 Is Necessary for Induction of Antiviral Genes during Human Cytomegalovirus Infection
... Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for the induction of interferon- stimulated genes ...the activation of ISGs by human ...
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Genetic Dissection of Interferon-Antagonistic Functions of Rabies Virus Phosphoprotein: Inhibition of Interferon Regulatory Factor 3 Activation Is Important for Pathogenicity
... HEp-2 cells, the former reached final titers only 10-fold below those of SAD ...infected cells and a more rapid establishment of an antiviral state in noninfected neighboring ...cell-autonomous ...
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Role of Interferon Regulatory Factor 3-Mediated Apoptosis in the Establishment and Maintenance of Persistent Infection by Sendai Virus
... cultured cells by paramyxoviruses causes cell death, mediated by a newly discovered apoptotic pathway activated by virus ...is interferon regulatory factor 3 (IRF-3), which upon ...
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Vpu Mediates Depletion of Interferon Regulatory Factor 3 during HIV Infection by a Lysosome-Dependent Mechanism
... HIV-1 infection cycle where viral products are sensed by the host cell to otherwise trigger innate immune signaling and IRF3 ...IRF3 activation during in- FIG 5 Vpu promotes the endolysosomal degradation of ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... transcription activation and DNA binding domain plasmids and for activation of reporter gene ...the activation domain plasmid ...human interferon (IFN) regulatory factor 3 ...
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Role of Interferon Regulatory Factor 7 in T Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection
... of infection, are capable of clearing an acute LCMV ...T cells, the activation of NP 396 -specific CD8 ⫹ T cells in IRF7 KO mice is significantly impaired compared to that in wild-type (WT) ...
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