[PDF] Top 20 Signaling pathways dictating pluripotency in embryonic stem cells

... ERK1/2 signaling autoinductive stimulation by Fibroblast growth factor or FGF4 is implicated in inducing differentiation of ...FGF4/ERK signaling pathway promotes the self-renewal of mESCs (Ying et ...ERK ... See full document

... FGF signaling is required to maintain hESC ...of pluripotency markers and differentiation of primitive endoderm and tropho- ectoderm (Dvorak et ...FGF signaling, is mainly devoted to the regulation ... See full document

... pluripotent stem cell lines tested prompted us to investigate whether they encode functional Rec protein and thus enable translation of HERV-K(HML-2) Gag and Env ...GH cells expressed the ... See full document

... than cells with high-NANOG, independently of the cell culture environment, and are also more predisposed to originate differentiated cell ...bias cells to specific lineages are not predetermined, and mESCs ... See full document

... pluripotent cells are sparse, and therefore a clear indication of the emergence of a new and important field of ...cell signaling and gene ...self-renewal, pluripotency and differentiation of both ... See full document

... ES cells is hindering their efficient expansion, and creates a selection pressure that may lead to the generation of variants harboring advantageous genetic changes which can overtake the culture (Amps et ...the ... See full document

... somatic cells reprogrammed into ...cient cells, but the molecular mechanism is unknown ...pluripotent stem cells. The Wnt signaling pathway has been shown to be essential for ... See full document

... ES cells is that -catenin competes with Groucho co-repressors for TCF3 binding (Cavallo et ...zebrafish embryonic development, although it has not been directly linked to Wnt signaling (Ro and ... See full document

... of pluripotency and conditions required to preserve this state in the early embryo is of great importance for understanding requirements for the maintenance of pluripotent cells in ...and ... See full document

... Additional file 4: Table S1. List of hiPSC lines used. Table S2. Number of identified genes in each sample, related to results section regarding RNA sequencing. Table S3. The 20 most significantly differentially ... See full document

... of cells that express both Notch receptors and ligands, can still bind Notch receptors but this association prevents ...endothelial cells, through aug- mented expression of Delta-4, prevent the ... See full document

... undifferentiated cells and cells expressing surface markers CD44+/CD24- (Dontu et ...Cancer cells sorted for CD44+/CD24- phenotype displayed increased tumourigenicity after injection into ... See full document

... Taking advantage of the high sensitivity of MaTaDa we were able for the first time to monitor PRDM14-chromatin association during the course of PGCLC specification. PRDM14 DNA binding in PGCLCs and ESCs differs ... See full document

... Complete the following table, which compares embryonic stem cells to adult stem cells.. Embryonic stem cells Adult stem cells.[r] ... See full document

... in embryonic stem cells (ESCs) led to a reduction of H3K4me3 levels particularly at promoters of highly transcribed genes (Clouaire et ...express pluripotency markers (Carlone et ... See full document

... epiblast cells, which then becomes restricted once the cells start to be committed, is also shared by the zebrafish, Xenopus and mouse homologues, which have been implicated in regulation of early neural ... See full document

... in embryonic stem cells, in which it makes up 2% of all polyadenylated ...ES cells lose pluripotency, to the point where its expression is undetectable in ...iPS cells, though ... See full document

... maintain pluripotency We generated a series of inducible knockout mESCs by serial modifications of the endogenous alleles of Klf2, Klf4 and Klf5 with introduction of loxP sites and a tamoxifen (Tx)-inducible form ... See full document

... state pluripotency is the hallmark of embryonic stem cells (ESCs), defining cells with the potential to produce any somatic cell type or primordial germ cells (PGCs), which ... See full document

... 39]. Embryonic human tissues express the greatest diversity of TE-associated TSSs ob- served to date [33], highlighting the potential of TEs to drive cell type and developmental stage-specific expres- sion, ... See full document