[PDF] Top 20 Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
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Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... that during latent infections, a primary tran- script initiating from LAP1 is spliced to produce the 2-kb ...primary transcript, perhaps the ...(4a). During lytic ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...individual. During ... See full document
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Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency.
... by two independent ...or latent HSV-1 LAT expression or the HSV-1 reactivation phenotype in explanted mouse trigeminal ganglia ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... and herpes simplex virus type 1 ...the virus can also enter a latent state in these ...viral lytic and latent states is not understood. The ... See full document
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The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency.
... The latency-associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1) is unique among the many promoters on the viral genome in that ... See full document
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Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... of herpes simplex virus type 1 (HSV-1) infection is the ability of the virus to establish a lifelong latent state in neurons of the sensory ganglia (13, ...The ... See full document
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... a latent infection, and thus these cell lines may vary considerably in the quantity and specificity of their transcription ...vivo infections described ...infected two different neuronal cell ...gene ... See full document
7
Genetic Studies Exposing the Splicing Events Involved in Herpes Simplex Virus Type 1 Latency-Associated Transcript Production during Lytic and Latent Infection
... LAT expression dur- ing ...production during latent infection and whether an effect could be observed for the inner splice site mutations, the wt and mutant recombinant viruses were inoculated onto ... See full document
11
CTCF-Dependent Chromatin Boundary Element between the Latency-Associated Transcript and ICP0 Promoters in the Herpes Simplex Virus Type 1 Genome
... the two studies could derive from different assay systems and different DNA fragments ...activity associated with the larger ...or promoters located nearby) from the LAT ...the latency ... See full document
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During Herpes Simplex Virus Type 1 Infection of Rabbits, the Ability To Express the Latency-Associated Transcript Increases Latent-Phase Transcription of Lytic Genes
... that, during latency, a LAT promoter deletion virus displayed greater leakiness of lytic transcripts than did the wild type in mice infected via the ocular route ...the lytic ... See full document
5
Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... (25). Two HSV transgenic mouse lines containing portions of the LAT have been previ- ously ...of expression of the 2.0-kb LAT intron on acute and latent HSV-1 infections in vivo ...of ... See full document
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Transcription of the Herpes Simplex Virus Latency-Associated Transcript Promotes the Formation of Facultative Heterochromatin on Lytic Promoters
... allow active gene expression. Because HSV-1 must over- come gene silencing for reactivation, it makes sense that viral lytic promoters on at least a portion of viral genomes are ... See full document
9
The Latency-Associated Transcript Inhibits Apoptosis via Downregulation of Components of the Type I Interferon Pathway during Latent Herpes Simplex Virus 1 Ocular Infection
... The herpes simplex virus (HSV-1) latency-associated transcript (LAT) has been shown to inhibit apoptosis via inhibiting activation of proapoptotic ...LAT transcript ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... marker-rescued virus dLAT2903R, dLAT371 and its marker-rescued virus dLAT371R, and ...LAT transcript(s) made by each virus are detailed in ...contain two copies of LAT, one in each ... See full document
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Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... between two possi- bilities: the RNA sequence is not present, presumably because of trimming, or the sequence is present but some steric block, like the nearby branchpoint, interferes with efficient hybridiza- ... See full document
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Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.
... These data demonstrate that i during an acute infection the transcripts of a number of HSV-1 genes involved in the lytic replication cycle rapidly increase and decrease over a 7-day peri[r] ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... 18. Song HW, Kumar BK, Kim SH, Jeon YH, Lee YA, Lee WT, et al. Agmatine enhances neurogenesis by increasing ERK1/2 expression, and suppresses astrogenesis by decreasing BMP 2,4 and SMAD 1,5,8 expression in ... See full document
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Physical characterization of the herpes simplex virus latency-associated transcript in neurons.
... 1194 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest RNA transfer Northern blot analysis was used to perform the physical characterization of the transcript expressed i[r] ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... in latency (11, 22, ...pseudorabies virus, and bovine herpesvirus lends support to such ...methylation during the latent phase, in maintaining the availability of the LAT pro- ...gene ... See full document
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PrPc Expression Influences the Establishment of Herpes Simplex Virus Type 1 Latency
... In our study we have utilized the TUNEL assay, which de- tects fragmented DNA, to measure apoptosis. It has been suggested that TUNEL identifies cells that have undergone not only apoptosis but also necrosis and ... See full document
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