Top PDF Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
... of latently infected tissues at 28 dpi de- tected ICP0 transcripts not only in the TG and the SCG, which were positive by ISH, but also in other latently infected struc- tures ...
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Herpes Simplex Virus Type 2 (HSV-2) Establishes Latent Infection in a Different Population of Ganglionic Neurons than HSV-1: Role of Latency-Associated Transcripts
... with herpes simplex virus type 1 (HSV-1) and HSV-2 is characterized by viral replication at the site of inoculation, followed by retrograde axonal transport of the virus ...
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... Herpes simplex virus type 1 establishes latent infections in sensory ...During latency only one locus, the latency-associated transcript (LAT), is abundantly ...
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Influence of Herpes Simplex Virus 1 Latency-Associated Transcripts on the Establishment and Maintenance of Latency in the ROSA26R Reporter Mouse Model
... HCl, 1 mM EDTA [pH 8]) overnight at ...(7). Virus genome was quantified with ICP0 promoter-specific primers, and adenine phosphoribosyltransferase (APRT) was utilized as a cellular DNA ...The ...
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Evidence that the Herpes Simplex Virus Type 1 ICP0 Protein Does Not Initiate Reactivation from Latency In Vivo
... the herpes simplex virus lytic cycle from the latent viral genome are not ...this type of analysis and use this strategy to test the established hypothesis that the herpes ...
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CTCF-Dependent Chromatin Boundary Element between the Latency-Associated Transcript and ICP0 Promoters in the Herpes Simplex Virus Type 1 Genome
... Cells latently infected with herpes simplex virus (HSV) contain nucleosomal DNA similar to that of host cell ...the latency-associated transcript (LAT) pro- moter and ...
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The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... The latency-associated transcript (LAT) gene the only herpes simplex virus type 1 (HSV-1) gene abundantly transcribed during neuronal latency, is essential ...
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Localization of Herpes Simplex Virus Type 1 DNA in Latently Infected BALB/c Mice Neurons Using in situ Polymerase Chain Reaction
... viral infected cells is very important in some ...per latently infected cell has been calculated to be in the range of 10 to 100 copies [18, ...LAT-expressing neurons ranges between 5 to 30% ...
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Spontaneous Reactivation of Herpes Simplex Virus Type 1 in Latently Infected Murine Sensory Ganglia
... of virus on the ocular surface of the rabbit (2), our data do not support a role for LAT in facilitat- ing spontaneous reactivation in the ...from latently infected TG is significantly less than that ...
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Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.
... In latently infected neurons, herpes simplex virus type 2 (HSV-2) expresses one abundant family of tran- scripts, the latency-associated transcripts ...
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A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.
... a herpes simplex virus type 1 (HSV-1) deletion mutant to identify a segment of the genome necessary for epinephrine-induced reactivation in the rabbit eye model of herpetic ...
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... of latency is not yet ...ganglia infected with LAT null mutants and that at least some of the cells undergoing apoptosis are neurons ...of neurons was performed, the authors speculated that ...
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... the infected neurons segregate into two distinct ...the neurons which express the b -galactosidase gene from the LAT promoter do not express any HSV-1 antigens and are thus ...
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Gamma Interferon Can Prevent Herpes Simplex Virus Type 1 Reactivation from Latency in Sensory Neurons
... the latently in- fected mouse TG is associated with the presence of the cyto- kines IFN-␥, tumor necrosis factor alpha, and interleukin-6, suggesting persistent activation of the infiltrating cells (4, 10, ...
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Immunohistochemical Analysis of Primary Sensory Neurons Latently Infected with Herpes Simplex Virus Type 1
... wild-type virus at establishing latent infection in the murine DRG (8, ...of latency is anatomical site ...of latently infected neuronal phenotypes in pri- mary sensory ...deletion ...
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Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... from latently infected trigeminal ganglia (12); the possibility that specific regions were methyl- ated was not ...was associated with specific methylation of corresponding inte- grated DNA sequences ...
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Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts.
... In contrast to the results with polyA+ RNA, polyA- RNA from infected rabbit skin cells and polyAor total RNA from latently infected murine sensory nerve ganglia protected a 190-base frag[r] ...
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Neurons Differentially Activate the Herpes Simplex Virus Type 1 Immediate-Early Gene ICP0 and ICP27 Promoters in Transgenic Mice
... in latently infected neurons, it does not appear that VP16 is involved in reactivation from ...HSV-1. Latency could be main- tained either by a decreased level or absence of host ...
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The Probability of In Vivo Reactivation of Herpes Simplex Virus Type 1 Increases with the Number of Latently Infected Neurons in the Ganglia
... HSV latency and the frequency of reactivation both in vitro and in vivo has been examined by a number of ...in latently infected ganglia (1, 2, 4, 8, 10, 13–16, 34), (ii) the number of ...
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Reversal of Heterochromatic Silencing of Quiescent Herpes Simplex Virus Type 1 by ICP0
... concentration, 1 mM), ...of 1:10 dilutions from 250,000 to 25 copies per well, which covers the threshold cycle values for the ChIP DNA samples ...mutant virus genome that contains the same ICP27/ ...
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