[PDF] Top 20 Skeletal muscle inflammation and insulin resistance in obesity

... and inflammation, which all occur in obesity, via hemodynamic (blood flow reduction) or non-hemody- namic effects (109, ...reduce inflammation, including SM and AT inflammation induced by ... See full document

... by insulin, emerging evidence suggests that it is not sufficient and another pathway may also be necessary (4, ...mediates insulin stimulation of glucose ...of insulin. For example, the antilipolytic ... See full document

... the extent of macrophage infi ltration (Strissel et al 2007). These data indicate that infi ltrated macrophages are involved in clearance of cell debris, leaked lipids and perhaps are important for adipose tissue ... See full document

... Whether the expression of the LY86 gene is regulated by DNA methylation remains unknown. According to the most recent release of Genome Browser, the CpG sites showing higher methylation levels in the obese subjects from ... See full document

... which obesity has been labeled one of the most fundamental causes (Hu et ...2001). Obesity is a systemic inflammatory response, and many inflammatory mediators exhibit expression patterns that interfere ... See full document

... femoral muscle by dividing glucose uptake by blood flow, we found glucose extraction to be 64% lower in the obese than in the nonobese ...for insulin resistance in ...human skeletal ... See full document

... of obesity- induced insulin ...on insulin sensitivity, our search for the basis for altered IgG action excluded changes in IgG ...and insulin resistance invoked in mice by HFD-IgG was ... See full document

... somatostatin, insulin, and glucose, however, was significantly lower in obese than in nonobese subjects, and was inversely correlated with ...with insulin binding to circulating monocytes. Insulin ... See full document

... the obesity is a strong predisposing risk factor for IR, the pathogenesis of this process is critically related to adipose tissue defects rather than the obesity degree and adipose tissue ... See full document

... promotes insulin sensi- tivity in skeletal ...to skeletal muscle, improves insulin sensitivity ...of insulin sensitivity translates to ...in skeletal muscle of ... See full document

... recommended insulin treatment regime for T1D patients is intensive insulin therapy with the target of maintaining normal HbA1c (approximately ...daily insulin injections or an insulin pump ... See full document

... profile, we suggest a possible role of mangosteen in the treatment of obesity, insulin resistance and 30.. inflammation.[r] ... See full document

... abdominal obesity, essential hypertension, glucose intolerance and hypertriglyceride- mia, in which insulin resistance plays a central role, in- vestigations of the latter are ...crucial. ... See full document

... are skeletal muscle, liver and adipose tissue. In skeletal muscle and adipose tissue, insulin promotes glucose uptake into the cells by activating a complex cascade of phosphorylation- ... See full document

... conditions. Obesity is commonly associated with increased production of proinflammatory cytokines, insulin resistance, and changes in body fat ...potentiate insulin resistance and ... See full document

... drives inflammation and insulin resistance in obesity Inflammation mediated by increased cytokine produc- tion and excess fatty acids or ‘lipotoxicity’ activate inflammatory pathways in ... See full document

... that insulin resistance is a major factor in the pathogenesis of type 2 diabetes (1, 2), the precise mechanism by which insulin resistance leads to the development of type 2 diabetes is uncer- ... See full document

... link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihypergly- cemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance ... See full document

... rat skeletal muscle ...that skeletal muscle is a primary tissue responsible for glucose disposal, glucose oxidation and insulin resistance, this study investigated a potential ... See full document

... mediating skeletal muscle ...modulate skeletal muscle fatty acid transport and oxidation, glycolysis, insulin resistance/sensitivity, energy and oxidative ...in skeletal ... See full document