[PDF] Top 20 Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix
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Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix
... ENS development relies on reciprocal interactions between ENCCs and their environment that are crucial for ENCC survival, migration, proliferation, patterning and ...that extracellular matrix ... See full document
12
Region specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord
... with extracellular matrix molecules such as heparan sulfate proteoglycans (HSPGs) (Callejo et ...Furthermore, hedgehog-interacting protein (Hhip), a membrane glycoprotein, can bind to Shh, thereby ... See full document
11
Patterning the nervous system through development and evolution
... In order to examine this property, Pourquié labeled posterior mesoderm cells and studied their behavior through time-lapse analyses. He first observed that more posterior cells migrate fast in the caudal direction, ... See full document
14
Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
... the Hedgehog (Hh) family are powerful signaling molecules that act as morphogens, controlling growth and patterning in certain tissues of a range of different organisms at different developmental stages ... See full document
13
Restriction of sonic hedgehog signalling during early tooth development
... During the initiation process, expression of Shh is localised to the epithelial thickenings of future teeth (Bitgood and McMahon, 1995; Hardcastle et al., 1998), and there is in vitro evidence to suggest that Shh acts as ... See full document
11
Retinal ganglion cell derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina
... RGC development at E13 in the ␣ -Cre;Shh –/c mutant suggested that Shh might also antagonize RGC ...in development when RGC development is maximal, with either recombinant N-terminal fragment of Shh ... See full document
11
The Role of Sonic Hedgehog in the Hypothalamus
... Second, Shimogori et al. (2010) deleted Shh from the hypothalamus, the POA, and the MGE using Nkx2.1-cre;Shh loxP/loxP mice. Similar to Szabó et al. (2009), this group noticed an expansion of the third ventricle and ... See full document
120
Distinct Temporal Requirements For Sonic Hedgehog In The Development Of The Tuberal Hypothalamus
... Sonic hedgehog (Shh) is a secreted morphogen that plays integral roles in the development of several brain and spinal cord ...the development of the hypothalamus has presented a challenge ... See full document
118
A highlight on Sonic hedgehog pathway
... Hh: Hedgehog; IFT80: Intraflagellar transport protein 8; Ihh: Indian-Hedgehog; MB: Medulloblastoma; Mek1: Mitogen activated protein kinase kinase; MGMT: O-6-methylguanine-DNA methyltransferase; NSCs: Neural ... See full document
15
Sonic hedgehog dependent synthesis of laminin α1 controls basement membrane assembly in the myotome
... specialised extracellular matrix structures that consist mainly of the glycoproteins laminin and nidogen, of collagen IV, and of the heparan sulphate proteoglycan (HSPG) perlecan, and are key to several ... See full document
10
Heparan Sulfate Proteoglycan Agrin in CNS Development and Aging
... the extracellular domains that are required for agrin responsiveness, these data provide support for the hypothesis that agrin’s effects on zebrafish development are mediated by MuSK-independent ... See full document
140
Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review.
... ABSTRACT. Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different ... See full document
15
Cholesterol precursors and facial clefting
... malformations. Sonic hedgehog and cleft palate The discovery that cholesterol is necessary for the maturation of hedgehog proteins (12) provided insight into a developmen- tal pathway that is likely ... See full document
5
“Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a review
... the enteric nervous system (ENS) are entirely derived from the neural crest which is a transi- ent, multipotent cell population originating from the neural tube [8, ...as enteric neural ... See full document
11
Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects
... IGF1 did not alter the time course of OPC generation either (data not shown). Alternatively, this protracted transition might be intrinsically controlled. The long OPC-specification process (3 months) appears to match ... See full document
10
Roles of extracellular microRNAs in central nervous system
... the extracellular space including a wide range of body ...These extracellular miRNAs, often encapsulated in secreted extracellular vesicles, can be transferred into recipient cells and thus inhibits ... See full document
7
Understanding the role of the Sonic Hedgehog signaling pathway in cerebellar development and medulloblastoma genesis
... migration reside in the niche of the EGL whereas the vast majority of GNPs mature and organize correctly. Intriguingly, in the SmoA2 developing cerebellum the vast majority of GNPs undergo abnormal migration and manifest ... See full document
129
Migration of neural crest derived enteric nervous system precursor cells to and within the gastrointestinal tract
... It is difficult to explain the discrepancies between the findings of these experiments, where one set of results describes the early migration of sacral NCC into the hindgut, whereas the other presents evidence to the ... See full document
8
<p>Antidepressant, anti-inflammatory, and antioxidant effects of electroacupuncture through sonic hedgehog–signaling pathway in a rat model of poststroke depression</p>
... Keywords: electroacupuncture, poststroke depression, sonic hedgehog – signaling pathway, oxidative stress, in fl ammation, 5HT.. Introduction.[r] ... See full document
9
The Design, Synthesis, and Biological Evaluation of Steroid-Derived Inhibitors of the Sonic Hedgehog Signaling Pathway
... Due to the lack of structural information prior to the Stevens’ publication, the classification of SMO as a canonical GPCR had been controversial. The amino acid sequence of SMO demonstrates high similarity to Frizzled ... See full document
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