[PDF] Top 20 Spotlight on eltrombopag in the treatment of children with chronic immune thrombocytopenia

... In adult trials with eltrombopag, there were both venous and arterial thrombotic events reported in patients, and these were observed even at low or normal platelet count. In the two reported pediatric clinical ... See full document

... of chronic ITP is the notion that the disease, its treatment, and associated sequelae may impact children and their parents with respect to physical, mental, emotional, and social health ...for ... See full document

... in children with cITP who have had an insufficient response to corticosteroids, immunoglobu- lins, or ...available treatment options for pediatric ITP ...the treatment of pediatric cITP patients in ... See full document

... medications. Eltrombopag requires dietary modi fi cation around the time of medication administration due to the presence of divalent cations such as calcium, magne- sium and iron, which interfere with medication ... See full document

... Emergency treatment: ITP patients with severe thrombocytopenia will require their platelet count to be raised rapidly if they have a major bleed or if they need emergency ...Emergency treatment ... See full document

... with chronic diseases, which attracts our attention to explore the quality of life of childhood chronic ITP [13, ...analyzing treatment effects ...on chronic ITP HRQoL, which barely related to ... See full document

... the treatment of immune thrombocytopenia and the fi rst approved to treat periprocedural thrombocytopenia in patients with chronic liver disease (thereby providing an alternative to ... See full document

... Abstract: Immune thrombocytopenia (ITP) is an acquired bleeding autoimmune disorder characterized by a markedly decreased blood platelet ...in children and a more chronic course in ...both ... See full document

... of eltrombopag treatment but it did not cause any interruption in the treatment and disappeared spontaneously over ...to eltrombopag treatment which was prior use of corticoste- roids ... See full document

... “Immune thrombocytopenia” (ITP) is an autoimmune disorder that leads to peripheral destruction, as well as a decreased production of ...for thrombocytopenia in adults with ...and eltrombopag, ... See full document

... sion, which refers to cases of half recovery among the cITP cases. We analyzed the following patient characteristics: age at diagnosis, sex, platelet counts at initial diagnosis and at cITP diagnosis, and ... See full document

... Methods: A cost-consequence model was developed to evaluate the costs relative to treatment success of EPAG, ROMI, and watch and rescue (W&R) in previously treated patients. The primary endpoint assessed was ... See full document

... With Eltrombopag [RAISE]; ...comparing eltrombopag to placebo, eltrombopag produced clinically meaningful and statistically significant differences versus placebo as an addition to standard of care, ... See full document

... (idiopathic) thrombocytopenia (ITP) is an autoimmune condition characterized by increased platelet destruction and suboptimal platelet production, resulting in low platelet counts (thrombocytopenia) ...a ... See full document

... (idiopathic) thrombocytopenia (ITP) is an autoimmune condition characterised by increased platelet destruction and suboptimal platelet production, resulting in low platelet counts (thrombocytopenia) ...a ... See full document

... and thrombocytopenia, as well as the risk of major ...moderate thrombocytopenia and minor bleeding, except for patients with a lifestyle estimated to be at high risk for bleeding (police officers, ... See full document

... and treatment for thrombocytopenia is so exten- sive and varied, a thorough history and physical examination, with attention to possible alternative explanations for thrombocytopenia is ...of ... See full document

... adequate treatment length in the high-risk setting, whereas it is not beneficial in the low-risk ...effective treatment together with the other existing fertility preservation ...adjuvant treatment ... See full document

... Almost all patients diagnosed with ITP have signs of cutaneous bleeding (petechiae, purpura, and ecchymoses). Mucosal bleeding can occur in as many as 40% of children, usually involving the nasal passages and ... See full document

... severe immune thrombocytopenia was based on the presence on unexplained fall in platelet count to <30x10 9 /L and on more than two indirect parameters: evidence of normal bone marrow function (normal or ... See full document