[PDF] Top 20 Stabilization of the Soluble, Cleaved, Trimeric Form of the Envelope Glycoprotein Complex of Human Immunodeficiency Virus Type 1
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Stabilization of the Soluble, Cleaved, Trimeric Form of the Envelope Glycoprotein Complex of Human Immunodeficiency Virus Type 1
... The envelope glycoprotein (Env) complex of human immunodeficiency virus type 1 has evolved a structure that is minimally immunogenic while retaining its natural ... See full document
15
Evaluating the Immunogenicity of a Disulfide-Stabilized, Cleaved, Trimeric Form of the Envelope Glycoprotein Complex of Human Immunodeficiency Virus Type 1
... content. Virus infection was measured by determining luciferase expres- sion in relative light units ...of virus infection and/or luciferase ...with 1 mg pPPI4 expressing soluble gp140 ... See full document
16
A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure
... neutralize human immunodeficiency virus type 1 (HIV-1) recognize the limited number of envelope glycoprotein epitopes exposed on infectious ...native ... See full document
17
Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex.
... the envelope glycoproteins seem worth ...HIV-1 envelope glycoproteins, in whatever form, is likely to require a greater knowledge of the way in which these antigens are best presented to the ... See full document
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Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein
... of soluble, cleaved gp140 trimers of the human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) for use in structural studies and as ...to ... See full document
13
SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
... State 1-preferring ...State 1 but also from States 2/3, which represent functional default confor- mations for Envs with the State 1-destabilizing L193R or I423A ...from stabilization of a ... See full document
14
Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein
... viral envelope glycoproteins have evolved to minimize the potential impact of neutralizing antibodies on virus ...HIV-1 envelope glycoprotein complex results in the elicitation ... See full document
12
Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus
... the virus after centrifugal ultrafiltration through a 300-kDa cutoff ...treated virus through a Percoll gradient showed that most of the SU did not cosediment with ...the virus during the ultra- ... See full document
11
Determinants of human immunodeficiency virus type 1 envelope glycoprotein oligomeric structure.
... influenza virus hemagglutinin transmembrane protein HA2 (27). The trimeric structure of hemagglutinin is stabilized primarily by hydropho- bic intermonomer interactions in the N-terminal half of the ... See full document
10
Peptides Trap the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Fusion Intermediate at Two Sites
... (Fig. 1) (reviewed in reference ...parallel, trimeric coiled-coil core, whereas three C-terminal HR (C-HR) form helices that pack in the grooves of the coiled-coil trimer in an antiparallel ... See full document
6
Compartmentalization of Surface Envelope Glycoprotein of Human Immunodeficiency Virus Type 1 during Acute and Chronic Infection
... highly complex mixture of species expands to fill a new environment by uncontrolled replication, genetic polymorphism is lost, sometimes completely (13, 16, 41, ...the form of immune surveillance and the ... See full document
9
Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.
... using soluble CD4 and a panel of MAbs, finding that the C2 substitution disrupted the CD4BS, which was restored to its wild-type function by the C1 compensatory substitution ...to form the ... See full document
12
Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1.
... the envelope glycoprotein of human immunodeficiency virus type 1 strain IIIB expressed on the surface of CHO ...CD4-positive human lymphoblastoid SupT1 cells or ... See full document
11
Alterations in the Immunogenic Properties of Soluble Trimeric Human Immunodeficiency Virus Type 1 Envelope Proteins Induced by Deletion or Heterologous Substitutions of the V1 Loop
... In this study we demonstrate that diverse V1 loops differing in loop length, in amino acid composition, and in the number of PNGs can be antigenically accessible and immunogenic in the context of a heterologous SF162 Env ... See full document
15
Stoichiometry of Envelope Glycoprotein Trimers in the Entry of Human Immunodeficiency Virus Type 1
... ⫽ 1 entry stoichiometry utilize protein receptors ...A virus, in which the binding of the HA1 glycoprotein to cell surface sialic acid serves mostly to attach the virus and allow targeting to ... See full document
16
Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers by Disulfide Bonds Introduced into the gp41 Glycoprotein Ectodomain
... mutant envelope glycoproteins were pre- cipitated from lysates of transfected cell by using specific anti- gp41 or anti-gp120 monoclonal ...this envelope glycoprotein mutant were predicted to ... See full document
6
Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers
... Human immunodeficiency virus type 1 (HIV-1) infection is a significant global public health problem for which development of an effective prophylactic vaccine remains a high ... See full document
8
Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies
... Human immunodeficiency virus type 1 (HIV-1) is the etio- logic agent of AIDS (5, 29, ...The envelope glycoproteins of HIV-1, gp120 SU and gp41 TM, are assembled in ... See full document
7
Antigenicity and Immunogenicity of a Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein
... a glycoprotein that could pseudotype an env-deficient HIV-1 provirus, CON6 gp160 was cotransfected with HIV-1/SG3 ⌬ env (along with the NL4-3 and YU2 gp160 genes for controls) into human 293T ... See full document
10
Functional Pseudotyping of Human Immunodeficiency Virus Type 1 Vectors by Western Equine Encephalitis Virus Envelope Glycoprotein
... cells, human foreskin fibroblasts, MCF7, CaCo2, T-84, HT29, HT1080, HepG2, C8166, PM1, SAOS2, HeLa, BSC-40, CHO, LMTK ⫺ , A9, 3T6, and COS7 cells (not ...or 1:1,000) of the antisera were utilized (total ... See full document
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