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[PDF] Top 20 Structural basis for DNA strand separation by a hexameric replicative helicase

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Structural basis for DNA strand separation by a hexameric replicative helicase

Structural basis for DNA strand separation by a hexameric replicative helicase

... the DNA, forming a ...of DNA it is unlikely that the observed protections are representative of partial E1–DNA complex ...the helicase motor ...the DNA protection pattern for the 3 ‘ac- ... See full document

13

Structural basis for DNA strand separation by a hexameric replicative helicase

Structural basis for DNA strand separation by a hexameric replicative helicase

... stable hexameric complexes of full length E1 with ssDNA and intact replication forks bound, determined structures at 18–23 ˚ A resolution and localized DNA replication fork entrance and exit points at the ... See full document

14

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

... with DNA. The struc- tures, in combination with other published helicase structures, provide detailed insights on the RecQ helicase mechanisms of DNA tracking, strand separation, ... See full document

6

Model for T-Antigen-Dependent Melting of the Simian Virus 40 Core Origin Based on Studies of the Interaction of the Beta-Hairpin with DNA

Model for T-Antigen-Dependent Melting of the Simian Virus 40 Core Origin Based on Studies of the Interaction of the Beta-Hairpin with DNA

... the structural distortions of the SV40 origin that occur during T-ag ...the structural distor- ...T-ag helicase domain preferentially oligomerizes on the strand containing the 3 ⬘ extension of ... See full document

11

Regulation of Bovine Papillomavirus Replicative Helicase E1 by the Ubiquitin-Proteasome Pathway

Regulation of Bovine Papillomavirus Replicative Helicase E1 by the Ubiquitin-Proteasome Pathway

... Papillomaviruses are small DNA tumor viruses which have the capacity to establish a persistent infection in mammalian epithelial cells. The complete papillomavirus replication cycle is tightly linked to the ... See full document

9

Purification and Characterization of West Nile Virus Nucleoside Triphosphatase (NTPase)/Helicase: Evidence for Dissociation of the NTPase and Helicase Activities of the Enzyme

Purification and Characterization of West Nile Virus Nucleoside Triphosphatase (NTPase)/Helicase: Evidence for Dissociation of the NTPase and Helicase Activities of the Enzyme

... three structural proteins, protein M, capsid protein C, and glycop- rotein E, and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5) (10, 11, ...RNA helicase with intrinsic ... See full document

10

Helicase Motif Ia Is Involved in Single-Strand DNA-Binding and Helicase Activities of the Herpes Simplex Virus Type 1 Origin-Binding Protein, UL9

Helicase Motif Ia Is Involved in Single-Strand DNA-Binding and Helicase Activities of the Herpes Simplex Virus Type 1 Origin-Binding Protein, UL9

... Limited proteolysis. Limited proteolysis using proteinase K was performed as described previously (30). Briefly, a Sephadex G75 gel filtration column was used to remove protease inhibitors used during protein ... See full document

12

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase

... facilitate DNA strand ...and hexameric helicase (53) engage both the translo- cating (active) and displaced (passive) ssDNA strands along distinct binding ...forked DNA substrates bound ... See full document

16

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase

... mM NaCl) relative to direct ssDNA binding assays (Fig- ure 6). ATP hydrolysis was assayed for wild-type and vari- ant forms. As expected hPIF1 E307Q, which is directly in- volved in ATP hydrolysis, had minimal measurable ... See full document

16

Structural Basis of DNMT1- and DNMT3A-Mediated DNA Methylation

Structural Basis of DNMT1- and DNMT3A-Mediated DNA Methylation

... CXXC domain in inhibiting the de novo methylation activity of DNMT1, the major maintenance 192.. DNA methyltransferase.[r] ... See full document

28

Overexpression of the Replicative Helicase in Escherichia coli Inhibits Replication Initiation and Replication Fork Reloading

Overexpression of the Replicative Helicase in Escherichia coli Inhibits Replication Initiation and Replication Fork Reloading

... accessory replicative helicase Rep, resulting in increased replication blockage and thus increased reinitiation away from oriC, also exacerbates DnaB-induced ...of helicase perturb replication ... See full document

13

An experimental study of the putative mechanism of a synthetic autonomous rotary DNA nanomotor

An experimental study of the putative mechanism of a synthetic autonomous rotary DNA nanomotor

... In all cases, it was necessary to test whether the triangle structures had folded completely. Two primary folding ‘errors’ are conceivable. Either a staple could be ‘half-bound’, where one domain is attached to the ... See full document

12

Initiation of Minute Virus of Mice DNA Replication Is Regulated at the Level of Origin Unwinding by Atypical Protein Kinase C Phosphorylation of NS1

Initiation of Minute Virus of Mice DNA Replication Is Regulated at the Level of Origin Unwinding by Atypical Protein Kinase C Phosphorylation of NS1

... virion DNA to keep its flip orientation (9, 22; Christensen et ...the DNA template in absence of ATP (Christensen et ...origin DNA around the nick site and/or to stabilize this energetically ... See full document

10

Systematic Study of the Functions for the Residues around the Nucleotide Pocket in Simian Virus 40 AAA+ Hexameric Helicase

Systematic Study of the Functions for the Residues around the Nucleotide Pocket in Simian Virus 40 AAA+ Hexameric Helicase

... examine DNA binding using a fluores- cently labeled ss- or dsDNA probe both in the absence and in the presence of ATP or ATP- ␥ ...of DNA (see equation ... See full document

7

The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation

The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation

... CLL is characterized by an abnormal expansion of mature B lymphocytes. Reliable prognostic factors are crucial for choosing therapeutic strategies in CLL patients and in predicting the outcome (reviewed by Kipps) [26]. ... See full document

10

Hmi1p and UvrD : two Superfamily I helicases and their respective roles in S. cerevisiae mtDNA maintenance and E. coli methyl-directed mismatch repair

Hmi1p and UvrD : two Superfamily I helicases and their respective roles in S. cerevisiae mtDNA maintenance and E. coli methyl-directed mismatch repair

... the DNA-stimulated ATPase reaction catalyzed by ...Hmi1p-catalyzed DNA unwinding and the purified protein demonstrates optimal unwinding activity at 2 mM rATP with half maximal reaction velocity at an ATP ... See full document

116

Isolation and structural characterization of monomeric and dimeric forms of replicative intermediates of Kilham rat virus DNA.

Isolation and structural characterization of monomeric and dimeric forms of replicative intermediates of Kilham rat virus DNA.

... DNA from pools C and C', i.e., an "alkaline" single-stranded dimer, renatured when neutralized, and then it was eluted at 0.55 M phosphate from hydroxyapatite data not shown and sediment[r] ... See full document

10

Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes.

Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes.

... The existence of coding sequences on the other strand of papillomavirus DNA cannot be absolutely ruled out on the basis of the sequence analysis, but two observations make it unlikely: i[r] ... See full document

10

Functional interplay of DnaE polymerase, DnaG
primase and DnaC helicase within a ternary complex, and primase to polymerase hand off during lagging strand DNA replication in Bacillus subtilis

Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand off during lagging strand DNA replication in Bacillus subtilis

... before being added to the reaction mixture containing the DNA substrate. Significant stimulation of the helicase activity was observed with concomitant poly(A) primer synthesis (Figure 6A and B). The poly(A) ... See full document

18

Studies on the Mechanism of Replication of Adenovirus DNA II. The Nature of Single-Stranded DNA in Replicative Intermediates

Studies on the Mechanism of Replication of Adenovirus DNA II. The Nature of Single-Stranded DNA in Replicative Intermediates

... Hybridization experiments of the singlestranded DNA with isolated complementary strands of adenovirus type 5 DNA showed that this DNA hybridized only with the viral L-strand the strand w[r] ... See full document

8

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