[PDF] Top 20 Structural and functional Alterations of FLT3 in Acute Myeloid Leukemia
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Structural and functional Alterations of FLT3 in Acute Myeloid Leukemia
... processes, FLT3 activation plays a critical role in governing normal hematopoiesis and cellular ...Optimum FLT3 function requires the coordinated effort of other growth factors such as SCF, and ...early ... See full document
16
Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
... of FLT3 mutations in AML, approximately 20 different experi- mental and/or clinical FLT3 inhibitors have been devel- oped and described in the literature ...generation FLT3 inhibitor that appears to ... See full document
10
The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia
... a structural model of the MRX-2843:FLT3 complex was ...to FLT3 was derived from a crystal structure featuring UNC569, a close MRX-2843 analog, bound to MERTK (PDB:3TCP; ...WT FLT3, ... See full document
17
Original Article Double CEBPA mutations are prognostically favorable in non-M3 acute myeloid leukemia patients with wild-type NPM1 and FLT3-ITD
... of acute myeloid leukemia (AML) is the differentiation arrest and neoplastic accumulation of myeloid precursor cells in the bone ...these structural rearrangements disturb normal pro- ... See full document
11
Acute Myeloid Leukemia—Genetic Alterations and Their Clinical Prognosis
... The FLT3 gene encodes a receptor tyrosine kinase (RTK) that plays a critical role in hematopoiesis and cell growth because it regulates diverse cellular processes such as proliferation, differentiation and ...in ... See full document
12
CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
... of FLT3-ITD mutation, improving the knowledge of this AML subgroup pathophysiology appears as an essential task for the next ...by FLT3- ITD have been identified, but downstream effectors, as well as their ... See full document
18
Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia
... precise functional effect of the NPM1 mutation is incom- pletely understood, several groups confirmed that NK- AML patients have a high incidence of NPM1 exon 12 mutations (~24% – 60%) ... See full document
5
Spotlight on midostaurin in the treatment of FLT3-mutated acute myeloid leukemia and systemic mastocytosis: design, development, and potential place in therapy
... of acute myeloid leukemia (AML) patients where it is associated with poor ...oncogenic FLT3 and the dependency on its constitutively activated kinase activity for leukemia growth make ... See full document
8
The Philadelphia chromosome in leukemogenesis
... ABL1 protein, one of the non-receptor TKs, is present throughout hematopoietic development, with declining levels during myeloid maturation. The autophosphoryla- tion site in the activation loop of its SH1 domain ... See full document
15
Papadaki, Christina (2017): Detection of minimal residual disease in Acute Myeloid Leukemia with t(8;21) translocation. Dissertation, LMU München: Medizinische Fakultät
... of leukemia, and has been related to specific cytogenic changes: deletions or loss of 7q or 5q as well as 11q23 chromosomal abnormalities respectively (Tang et ... See full document
82
Clinical and biological implications of <em>IDH1/2</em> in acute myeloid leukemia with <em>DNMT3A<sup>mut</sup></em>
... Purpose: The incidence of DNMT3A mutations in acute myeloid leukemia (AML) is quite high and often confers a poorer prognosis. Another common gene involved in AML is IDH1/2. However, the influence of ... See full document
10
PIM 1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia
... Leukemia cell samples were obtained from 118 new diag- nosis patients between January 2010 and December 2014 from the Department of Hematology, First Affiliated Hospital of Second Military Medical University, ... See full document
9
Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: the Path to Least Resistance
... 23. Jiang, J.; Paez, J. G.; Lee, J. C.; Bo, R.; Stone, R. M.; DeAngelo, D. J.; Galinsky, I.; Wolpin, B. M.; Jonasova, A.; Herman, P.; Fox, E. A.; Boggon, T. J.; Eck, M. J.; Weisberg, E.; Griffin, J. D.; Gilliland, D. G.; ... See full document
7
Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
... cancer/ leukemia samples, have been developed in the past ...of myeloid leukemias, the antigen profiles of more mature cells are well defined, and the approach to deplete these (Lin+) cells from LSC is well ... See full document
21
Cost-effectiveness analysis for midostaurin versus standard of care in acute myeloid leukemia in the United Kingdom
... Diagnosed Acute Myeloid Leukemia (AML) Patients (pts) Age 18–60 with FLT3 Mutations (muts): an International Prospec- tive Randomized (rand) P-Controlled Double-Blind Trial (CALGB 10603/ ... See full document
13
Use of FLT3 inhibitors in acute myeloid leukemia remission induction or salvage therapy: systematic review and meta-analysis
... Third, due to limited patients included and various responses to different FLT3 inhibitor therapies, results of these stud- ies were inconclusive, leading to relatively large CIs of our pooled analysis. More ... See full document
18
An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia
... The pMIG plasmid containing human FLT3- ITD was previously described [34]. For retrovirus production, 6 µg pMIG-FLT3-ITD or empty vector were transfected into Phoenix E cells using Lipofectamine 2000 ... See full document
11
Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: the Path to Least Resistance
... mutant FLT3 receptor ...both FLT3-ITD and FLT3-D835Y mutant cell lines with an IC50 of less than 10nM ...of FLT3-ITD-TKD mutant lines, although TKD1 mutations may confer some resistance [118] ... See full document
35
Landscape of gene fusions in epithelial cancers: seq and ye shall find
... Genomic or transcriptomic sequencing has virtually supplanted molecular and cytogenetic techniques as the primary modality for discovery of gene fusions, and detection of gene fusions is increasingly incorporated into ... See full document
18
Schranz, Katrin (2019): Investigation of AML-specific FLT3 mutations – from next generation diagnostics to combined targeted therapy. Dissertation, LMU München: Fakultät für Biologie
... Truncated receptors showing the potential to promote leukemogenesis are for instance truncated variants of the colony-stimulating factor 3 receptor (CSF3R). CSF3R is a key player in neutrophil production, belonging to ... See full document
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