[PDF] Top 20 Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication
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Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication
... the virus replicated with two mismatches within this region ...viral replication, certain mismatches are ...with dengue fever and dengue hemorrhagic fever, ...viral replication ... See full document
16
The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis
... high RNA synthesis activity in vitro but delayed or impaired replication in vivo ...has RNA helicase activity, which could modulate RNA synthesis in the replication ...vitro ... See full document
12
Sequence and Structural Elements at the 3′ Terminus of Bovine Viral Diarrhea Virus Genomic RNA: Functional Role during RNA Replication
... extensive RNA folding (6, 22), it was important to establish the RNA secondary structure of the DI9c 39 UTR by experimental means prior to commencing a functional ...the structural detail of ... See full document
13
The RNA Replication Enhancer Element of Tombusviruses Contains Two Interchangeable Hairpins That Are Functional during Plus-Strand Synthesis
... reduce RNA synthesis, suggesting that 4 to 6 bp within the stem are optimal for RNA synthesis in ...gPR promoter, which is involved in initiation of minus-strand synthesis ...internal ... See full document
12
Structural and phenotypic analysis of Chikungunya virus RNA replication elements
... of RNA secondary or higher-order structures within the CHIKV genome or their potential function as RNA replication elements during virus ...quence element (CSE), consisting of two short ... See full document
17
Scanning Mutagenesis Studies Reveal a Potential Intramolecular Interaction within the C-Terminal Half of Dengue Virus NS2A Involved in Viral RNA Replication and Virus Assembly and Secretion
... encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES) element (gray box), the C-terminal 24 amino acids of E (E24), the entire NS protein regions (NS1 to NS5), the 3= UTR (right black line), ... See full document
15
Structural and Functional Characterization of Sapovirus RNA-Dependent RNA Polymerase
... a virus family regrouping animal (mainly vesivirus and lagovirus but also norovirus and sapovirus) and human pathogenic (exclusively norovirus [NV] and SV) ...hampered studies on the replication ... See full document
14
Overlapping Local and Long-Range RNA-RNA Interactions Modulate Dengue Virus Genome Cyclization and Replication
... local RNA elements at each end of the ...these RNA sequences disassembles the hairpin and dumbbell ...previous studies, supports the idea that conservation of alternative (mutually exclusive) ... See full document
8
Interplay of RNA Elements in the Dengue Virus 5′ and 3′ Ends Required for Viral RNA Replication
... UTR RNA is recognized only in the presence of the 5 ⬘ end sequence (16, ...SLA RNA element and the presence of 5 ⬘ -3 ⬘ CS and UAR complementarity, but not the primary sequence, are absolutely ... See full document
16
Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication
... the functional characterizations of putative NS4B gly- cans in mammalian and mosquito hosts, the other key finding of this work is the screening and identification of NS4B intragenic compensatory mutations that ... See full document
15
Structural and functional studies of novel mechanisms of Lassa fever virus nucleoprotein in immune suppression, viral RNA transcription and replication
... Immune system is a protecting system for an organism to detect and kill pathogen or tumor cells. Immune system comprises two types, innate immune system and adaptive immune system. Innate immune system acts rapidly upon ... See full document
201
Structural and functional studies of bacterial outer membrane lipopolysaccharide insertion and Schmallenberg virus replication
... coli) RNA under native ...for RNA binding. The crystal structure of the SBV NP-42-nt RNA complex is also significantly different form RVFV-NP-RNA ...NP-42-nt RNA complex, each protomer ... See full document
181
Hepatitis C Virus RNA Replication Requires a Conserved Structural Motif within the Transmembrane Domain of the NS5B RNA-Dependent RNA Polymerase
... a structural element involved in essential intramembrane protein-protein ...conserved structural element within the HCV and GBV-B NS5B TMDs is essential for the establishment of a ... See full document
5
Effect of Mutations in the Mouse Hepatitis Virus 3′(+)42 Protein Binding Element on RNA Replication
... negative-strand RNA and subgenomic RNAs by ...genomic RNA and subgenomic mRNAs that might be expressed after electroporation of mutant viral genomes which failed to give rise to viable virus in ... See full document
16
A Functional Link between RNA Replication and Virion Assembly in the Potyvirus Plum Pox Virus
... abolishes RNA polymerase slippage with the consequent truncation of PIPO (4, 6, ...suppress RNA silencing ...cis-acting RNA sequence present in the first 534 nucleotides (nt) of the P3 coding ... See full document
18
Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication
... We next assessed the accumulation of vRNA by RT-qPCR us- ing primers that amplify a region within the open reading frame (ORF) of the viral genome. Relative levels of vRNA were deter- mined by normalization to GAPDH and ... See full document
10
Functional motifs of delta antigen essential for RNA binding and replication of hepatitis delta virus.
... Lanes W, M, N, and MN contain the wild-type and mutants which are mutated in the middle domain, near the N terminus, or both of the leucine repeats for the small HDAg, respectively.. Pla[r] ... See full document
8
Promoter for Sindbis virus RNA-dependent subgenomic RNA transcription.
... This was accomplished by inserting an AvaIl fragment from JN22 junction sequences -20 to +2 from position 1353 corresponding to -6 from the subgenomic RNA start site to position 1641 int[r] ... See full document
8
A hepatitis C virus cis acting replication element forms a long range RNA RNA interaction with upstream RNA sequences in NS5B
... nucleotide sequences each representing different (up to 4) subtypes within the six genotypes of HCV using the program SFOLD. This generates a statistical sample of secondary structures from the Boltzmann ensemble of ... See full document
35
A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B
... potential functional role(s) of phylogenetically con- served RNA secondary structures in coding regions has been analyzed extensively by reverse genetic analysis, predominantly using antibiotic resistance ... See full document
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