[PDF] Top 20 STRUCTURAL STUDIES ON LAMELLARIN ALKALOIDS, TOTAL SYNTHESIS OF PURPURAMINE-K AND DEVELOPMENT OF NOVEL SYNTHETIC METHODOLOGIES.

... new synthetic methodologies is an important subject in organic chemistry for synthesis and conversion of bioactive natural compounds under mild reaction conditions with suitable ...classical ... See full document

... Aziridines are versatile synthetic intermediates for the synthesis of many biologically interesting molecules such as amino acids, heterocycles and alkaloids. They are well known carbon ... See full document

... key structural motif in many pharmacologically and biologically active compounds as well as in natural ...the synthesis of drugs, pigments and pharmaceuticals, but also for the development of ... See full document

... Aziridines are carbon electrophiles capable of reacting with various nucloephiles and their ability to undergo regioselective ring opening contributes to their synthetic value. The nucleophilic ring-opeing of ... See full document

... bastadin alkaloids and DC-3 to DC-8 are known bastadin ...bastadin alkaloids are ...diterpenes, lamellarin alkaloids, and amino acid ... See full document

... identified. The interesting aspect of this research work is starting from single compound to a variety of new ring systems. Number of methods adopted in each set of reactions is discussed in various chapters. The ... See full document

... Freshly cleaned lithium wire (17 mmol, 120 mg) was added to freshly distilled ammonia (150 m L) in a 250 mL 3-necked round-bottomed flask at -7 8 °C (acetone/dry ice) under an atmosphere of argon. On dissolution o f the ... See full document

... the synthesis and application of triphenylenes has continuously ...Several synthetic routes to triphenylenes have been developed, including the metal- catalyzed cyclotrimerization of three benzyne ... See full document

... Another method was visualized to obtain exclusively the syn allyl alcohol 11, which was successfully implemented in the synthesis as shown in scheme VIII. This scheme also had the same starting material, i.e., ... See full document

... enantioselective synthesis of optically active secondary ...the synthesis of thiazole and benzothiazole heterocycles, which exhibit potent pesticidal ...the synthesis of aminothiocyanates. The best ... See full document

... Similarly, several aryl amines reacted smoothly with 3, 4-dihydro–2H-pyran to give the corresponding pyranoquinolines in 82-90% yield. The reactions proceeded efficiently at ambient temperature under mild conditions to ... See full document

... corresponding Weinreb amide 22 in 92% yield. Ozonolytic cleavage of olefinic bond in 22 resulted in crude aldehyde which on one carbon homologation by treating with benzothiazol-2-yl-methyl sulfone (BT sulfone) 23 and ... See full document

... provided, via a reductive cyclization cascade, key intermediate 6. Compound 6 was converted into ketone 18 over three steps including a PCC-mediated allylic oxidation. 4a Intermediate 18 was elaborated to compound 19 ... See full document

... The indole nucleus is one of the most relevant structures in medicinal chemistry. In continuation of our research programme on the use of clays for organic transformations, we report herein a novel method for the ... See full document

... to synthetic design, still the ways that theory facilitates design will be relatively ...to synthetic design – known as retrosynthetic analysis—as my example of a systematic approach to synthetic ... See full document

... In all cases, the reactions were clean and highly diastereoselective, affording the corresponding endo 4 with only a minor amount of the other exo 5. Finally, the clay was recovered by filtration, washed with methanol ... See full document

... Having successfully completed the synthesis of the hexahydropyrroloindoline half of okaramine C, it could be coupled with reverse prenyl tryptophan derivative 1.4 prior to deprotection a[r] ... See full document

... 2H-1-Benzopyrans (chromenes) and 3,4-dihydro-2H-1-benzopyrans (chromanes) are important classes of oxygenated heterocycles that have attracted much synthetic interest because of the biological activity of ... See full document

... the synthesis of biologically active compounds particulary in the construction of antimalarial ...the synthesis of various halogen derivatives of quinolines for our ongoing project with a view to synthesize ... See full document

... Cleavage of the 1, 2 isopropylidene acetal of 38 in refluxing 30 % aq AcOH provided the lactol 39, which was subjected to oxidative cleavage in CH 2 Cl 2 using sodium periodate furnishe[r] ... See full document