[PDF] Top 20 Structural Variations on the Turn Unit of DNA Binding Hairpin Py Im Polyamides
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Structural Variations on the Turn Unit of DNA Binding Hairpin Py Im Polyamides
... Chemicals and solvents were purchased from Sigma-Aldrich and were used without further purification. Boc-γ-Abu-OH was purchased from Novabiochem. (R)-2,4-Fmoc Dbu(Boc)-OH and Boc-β-Ala-PAM resin were purchased from ... See full document
209
Synthesis and Structural Studies of Cyclic Py Im Polyamides
... a DNA B-form conformation, which prefers a C2’–endo sugar ...than DNA and a dramatically different minor and major groove ...the DNA helix has been shown to be highly conformationally mobile in ... See full document
363
Structural Modifications to DNA Binding Polyamides for Improved Biological Activity in Cell Culture
... fluorophore-labeled polyamides have revealed several parameters that affect cellular trafficking of these molecules, including number of heterocyclic ring pairs, relative Py/Im content and sequence, ... See full document
123
Localization of DNA binding polyamides in living cells
... of DNA with high affinity and ...distamycin, polyamides may bind the DNA minor groove as monomeric units or as antiparallel dimers, in a concentration-dependent ...manner. DNA association is ... See full document
37
Programming Protein Patterns on DNA Nanostructures with Pyrrole Imidazole Polyamides
... future binding events leading to a cascade ...of binding is the incorporation of dsDNA loops into specific tiles which have been used as a visual marker to distinguish logical ones from ...the ... See full document
131
Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides
... the turn unit can be ...of hairpin binding affinity have involved modifications of the turn ...the turn element to be three methylene units, resulting in the use of ... See full document
176
Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection
... Different levels of somatic mutation of VH1-3/VL3-10 encoded MAbs. Four anti-V3 MAbs were analyzed in this study, all derived from VH1-3/VL3-10 germ line gene segments with different levels of somatic mutation ... See full document
13
Synthesis of multimeric polyoma virus DNA in mouse L-cells: role of the tsA1S9 gene product.
... Having confirmed that unit size Py DNA genome is synthesized in tsAlS9 and in WT-4 cells incubated at 34 or 38.5°C 33, we sought to determine whether viral DNA is present as larger-molec[r] ... See full document
10
Synthesis, Characterization, DNA binding and spectral properties of complex [Ru(py)4(dppz)]2+
... properties of the two Ru(II) complexes were explored by spectroscopic methods and viscosity measurements.Their photocleavage behaviors towards pBR 322 were also investigated. The preparation of polypyridyl ruthenium (II) ... See full document
10
Positive Impact Program Evaluation
... the binding of polyamides 3 and 5 in the minor groove of double-stranded ...with DNA solutions comprised of the DNA sequences tested in the thermal denaturation ...fixed DNA ... See full document
175
The Demand for Current Public Expenditure in Fiji: Theory and Empirical Results
... to structural change and rising incomes; Peacock and Wiseman (1967) argue for “displacement associated with some crisis, such as war; and Nordhaus (1975) has argued a political business ... See full document
24
Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach
... resin-immobilised amines after the turn moiety are lower yielding, requiring longer coupling times and even doubling coupling regimes using conventional coupling chemistries. Therefore an immobilised C-terminal ... See full document
6
Detection of DNA by sequence specific fluorescent polyamides
... groove binding distamycin derivatives that can recognize a large number of predetermined DNA sequences with affinities that rival natural transcription ... See full document
9
Threshold Extension of Gallium Arsenide/Aluminum Gallium Arsenide Terahertz Detectors and Switching in Heterostructures
... to binding and the inherent CD signal of mithramycin, the highest concentration spectrum in Figure ...actual binding interactions, or possibly a change in the spectral properties of mithramycin over the ... See full document
244
A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution
... in DNA repair, hSSB1 also regulates both the stability and the transcriptional activity of p53 (17) and binds and protects p21 from ubiquitin mediated degrada- tion ...repairing DNA replication forks (19) ... See full document
11
A Structural Comparison Approach for Identifying Small Variations in Binding Sites of Homologous Proteins
... In order to exemplify how one could apply the described approach in drug design based on 3D structures, and achieve drug selectivity, we examine the difference in volumes and side chains of the respective amino acids ... See full document
11
A cloned polyoma DNA fragment representing the 5' half of the early gene region is oncogenic.
... The U peptide has been By using a recombinant plasmid, pPB90, con- identified in the middle T Ag found in Py-6, a taining Py DNA extending clockwise from the Py-transformed mouse cell li[r] ... See full document
9
Interaction of nuclear factor EF-1A with the polyomavirus enhancer region.
... EF-1A binding to Py site 1 is independent of cooperation with other EF-1A sites or the adjacent binding sites for PEA-1 and PEA-2, two murine nuclear factors that bind in the Py A enhanc[r] ... See full document
9
Biological Activity of a Py-Im Polyamide Androgen Receptor Antagonist
... vitro DNA relaxation and Top2α-DNA binding ...pHOT1 DNA in assay buffer ...Top2α-DNA binding assays, increasing amounts of Top2α-p170 fragment were added to aliquots of ... See full document
141
E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.
... Adenovirus ElA proteins repress transcriptional activation of various enhancers, including those of Py, and can stimulate DNA replication in quiescent cells, but ElA effects on Py DNA re[r] ... See full document
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