[PDF] Top 20 Structure-Function Analysis of the Epitope for 4E10, a Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody
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Structure-Function Analysis of the Epitope for 4E10, a Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody
... fusion structure (2, 14, 16, ...three neutralizing antibodies (4E10, 2F5, and ...existing neutralizing antibodies (2, 12, 15, 19, 22, 24, ...of 4E10 and 2F5 to gp41 peptides increases ... See full document
8
Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10
... The 4E10 antibody recognizes the membrane-proximal external region (MPER) of the HIV-1 Env glycoprotein gp41 transmem- brane subunit, exhibiting one of the broadest neutralizing activities ... See full document
15
Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L
... access-restricted epitope between and over- lapping the epitopes of 2F5 and ...and 4E10 were originally obtained as IgG3 antibodies in hybrid- omas derived from peripheral blood mononuclear blood lym- ... See full document
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The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2G12 Recognizes a Cluster of α1→2 Mannose Residues on the Outer Face of gp120
... three broadly neutralizing MAbs to HIV-1 were known (5, ...an epitope overlapping the CD4 recep- tor site (7, 51), and 2G12, which recognizes an epitope based around the C4/V4 region of ... See full document
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Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection
... antibodies function to constrain the virus to remain CD4 dependent, as proposed previously ...infection. Epitope mapping demonstrated that these antibodies were not 4E10-like, despite their ... See full document
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Susceptibility of Recently Transmitted Subtype B Human Immunodeficiency Virus Type 1 Variants to Broadly Neutralizing Antibodies
... against human immunode- ficiency virus type 1 (HIV-1) are unable to induce humoral immune responses of sufficient breadth and potency to protect against infection (20, ...even ... See full document
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4E10-Resistant Variants in a Human Immunodeficiency Virus Type 1 Subtype C-Infected Individual with an Anti-Membrane-Proximal External Region-Neutralizing Antibody Response
... the 4E10 MAb neutralizes the chimeras C1, C4, and C6 at similar antibody concentrations ...of 4E10-like ...for 4E10 recognition ...an epitope closely re- lated but not identical to the ... See full document
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Neutralization Synergy of Human Immunodeficiency Virus Type 1 Primary Isolates by Cocktails of Broadly Neutralizing Antibodies
... between neutralizing monoclonal antibodies (MAbs) against human immunodeficiency virus type 1 ...between human MAbs b12, 2G12, 2F5, and 4E10 in neutralization of ... See full document
11
Novel Ring Structure in the gp41 Trimer of Human Immunodeficiency Virus Type 1 That Modulates Sensitivity and Resistance to Broadly Neutralizing Antibodies
... the structure and function of gp41. Using the structure of Chan et ...trimeric structure is thus stabilized by a ring of amino acids Q655-Q553-V551 in ...the broadly neutralizing ... See full document
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Stable Docking of Neutralizing Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Monoclonal Antibodies 2F5 and 4E10 Is Dependent on the Membrane Immersion Depth of Their Epitope Regions
... 2F5 epitope and the 4E10 epitope of gp41 MPER may not be exposed in the prefusion state of gp41(11, ...and 4E10, do not bind to native prefusion gp41 on native virion membranes ...and ... See full document
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An Engineered Saccharomyces cerevisiae Strain Binds the Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody 2G12 and Elicits Mannose-Specific gp120-Binding Antibodies
... structure and remodeling (52), Gp38 is a cell wall-related se- cretory glycoprotein induced by nutrient deprivation (15), and YJL171c is a GPI-anchored cell wall protein of unknown func- tion induced in response ... See full document
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Monoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope Glycoprotein
... sensitive human monoclonal antibodies capable of broadly inhibiting binding of E2 to CD81 have been described (1, 9, 33, 34, 36, ...with human immunodeficiency virus type ... See full document
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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1.
... the virus-neutralizing capacity of antibodies to HIV-1 in hu- man ...that human MAb 2G12 broadly and potently neutralized the majority of clade B primary and T-cell line-adapted strains ... See full document
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Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens
... novel broadly cross-reactive NAbs and characterization of their conserved epitopes may have impli- cations for development of vaccines and therapeutics and for an understanding of the mechanisms of HIV entry and ... See full document
11
A neutralizing monoclonal antibody previously mapped exclusively on human immunodeficiency virus type 1 gp41 recognizes an epitope in p17 sharing the core sequence IEEE.
... of broadly neutralizing antibodies and cytotoxic T lymphocyte response against HIV-1 (2, 4, ...this virus (21). In this study we demonstrate that a neutralizing antibody against ... See full document
6
Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
... broad neutralizing activity of 4E10 against primary isolates of HIV-1 from subtypes A, B, C, D, and ...and broadly neutralizing MAb, the collected results on 4E10 and Z13 provide ... See full document
14
Molecular Features of the Broadly Neutralizing Immunoglobulin G1 b12 Required for Recognition of Human Immunodeficiency Virus Type 1 gp120
... of broadly neutralizing anti-HIV-1 monoclonal antibodies, IgG1 b12 is the best characterized at the molecular ...the antibody variable regions that influence binding activity (4, 9, ... See full document
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Identification and Characterization of a Peptide That Specifically Binds the Human, Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody b12
... three broadly conserved neutralizing epitopes have been identified thus far on the viral envelope; they are defined by human monoclonal Abs (MAbs) b12, 2G12, and ...discontinuous epitope that ... See full document
8
Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications
... reference structure is conserved in all three ...peptide structure, this water molecule bridges the ε nitrogen of the Trp666 indole ring with the backbone carbonyl ...this structure, the uncharged ... See full document
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An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10
... and 4E10 to recombinant ...Z13e1 epitope may overlap more with that of 4E10, the crucial residues of which are W672 and F673 (10, ...Since 4E10 recognizes a largely helical epitope, it ... See full document
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